Teratogenicity with Olanzapine

Prakash, Sathya; Kumar Chadda, Rakesh
January 2014
Indian Journal of Psychological Medicine;Jan-Mar2014, Vol. 36 Issue 1, p91
Academic Journal
Olanzapine, a 2nd generation antipsychotic, is in use in the clinical practice for nearly a decade and a half now. It is classified as a category C drug with very few reports of its toxic effects on the fetus. In general, the risk benefit analysis warrants its use in pregnancy. We report a case of microcephaly and anopthalmos associated with the use of olanzapine in pregnancy. Although a causal role cannot be unequivocally proven, it calls for larger studies to explore this issue.


Related Articles

  • A WARNING ON ANTI-DEPRESSANTS. Roan, Shari; Strote, Mary Ellen // Fit Pregnancy;Apr/May2005, Vol. 12 Issue 1, p36 

    Presents information on the effects of pregnant women's intake of anti-depressants on fetal development.

  • Warfarin.  // Reactions Weekly;11/21/2009, Issue 1279, p34 

    The article describes the case of a fetus who developed an intracranial hemorrhage and died. The fetus' mother was receiving oral warfarin after undergoing mitral valve replacement. Ultrasonography on the mother showed fetal cardiac arrest and her labor was induced after four days. Autopsy on...

  • Review. Experimental models used to measure direct and indirect ethanol teratogenicity. SHIBLEY Jr., IVAN A.; McINTYRE, TIMOTHY A.; PENNINGTON, SAM N. // Alcohol & Alcoholism;Mar1999, Vol. 34 Issue 2, p125 

    The teratogenic effects of ethanol have been widely studied in a variety of experimental models. In humans, ethanol teratogenicity results from both direct and indirect effects. This paper reviews the differences between direct and indirect effects of ethanol on the developing fetus....

  • The Safety of Thiopurines: New Data, New Decisions. Beaugerie, Laurent; Sokol, Harry; Seksik, Philippe; Cosnes, Jacques // Inflammatory Bowel Disease Monitor;2010, Vol. 10 Issue 4, p117 

    Thiopurines are widely used, for prolonged periods, as maintenance treatment in Crohn's disease and ulcerative colitis. Some safety concerns including blood toxicity, immunoallergic reactions, and teratogenicity have been recognized since the early development of these drugs. These established...

  • The Developmental Psychopathology of Perinatal Depression: Implications for Psychosocial Treatment Development and Delivery in Pregnancy. Goodman, Sherryl H.; Dimidjian, Sona // Canadian Journal of Psychiatry;Sep2012, Vol. 57 Issue 9, p530 

    Taking a developmental psychopathology perspective, our objective was to identify ways in which psychosocial treatment of depression during pregnancy may be enhanced. We first consider the state of evidence on psychosocial interventions for antenatal depression, next define key developmental...

  • Genetics of Gestational Diabetes Mellitus. Shaat, Nael; Groop, Leif // Current Medicinal Chemistry;2007, Vol. 14 Issue 5, p569 

    About 2-5% of all pregnant women develop gestational diabetes mellitus (GDM) during their pregnancies and the prevalence has increased considerably during the last decade. GDM is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during...

  • Labor pain and its management with the combined spinal–epidural analgesia: what does an obstetrician need to know? Kuczkowski, Krzysztof M. // Archives of Gynecology & Obstetrics;Mar2007, Vol. 275 Issue 3, p183 

    Most women rate pain of childbirth as the most painful experience of their lives. Lumbar epidural analgesia is widely considered as the most effective method of providing pain relief in labor. However, lumbar epidural analgesia for labor is not a standard (generic) procedure and many technical...

  • ACE inhibitors and birth defects.  // WHO Drug Information;2006, Vol. 20 Issue 2, p70 

    The article provides information on the results of a study on the effects of angiotension-converting-enzyme (ACE) inhibitors during the second and third trimester of pregnancy. It was reported that the exposure of ACE inhibitors can cause birth defects in new born such as joint contractures,...

  • ACE inhibitors and pregnancy.  // WHO Drug Information;2006, Vol. 20 Issue 2, p71 

    The article provides information on the effects of angiotensin-converting-enzyme inhibitor (ACE) on pregnancy. Intake of ACE during pregnancy creates risk of major congenital malformations in infants. As precautionary measures, the Food and Drug Administration adapted that ACE inhibitors are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics