Effects of Short-Term Administration of Haloperidol on the Background of Impairments to Brain Metabolism and Neuron Activity

Kopytova, F.; Dovedova, E.
March 2014
Neuroscience & Behavioral Physiology;Mar2014, Vol. 44 Issue 3, p348
Academic Journal
The effects of amphetamine and haloperidol on spike activity levels, the ability to acquire a conditioned defensive reflex to time, and the state of components of the dopaminergic system in neurons in the sensorimotor cortex and caudate nucleus in rabbits were studied. Chronic administration of amphetamine increased the level of neuron spike activity and the ability to acquire and reproduce conditioned reflexes in the sensorimotor cortex, and decreased these parameters in the caudate nucleus. Biochemical studies demonstrated hyperactivation of the dopaminergic system in the caudate nucleus, as compared with the sensorimotor cortex. On the background of chronic amphetamine, haloperidol induced effects in both locations which were close to those of single doses to intact animals. The neuroleptic led to suppression of neuron activity and a decrease in the number of conditioned reactive neurons in the sensorimotor cortex, in contrast to neurons in the caudate nucleus. Short-term exposure to haloperidol produced changes in biochemical parameters towards normalization of neurotransmitter metabolism.


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