TITLE

Effects of Antagonists of Mu and Kappa Opioid Receptors on Aggressivity in Male Mice with Repeated Experience of Aggression

AUTHOR(S)
Bondar', N.
PUB. DATE
March 2014
SOURCE
Neuroscience & Behavioral Physiology;Mar2014, Vol. 44 Issue 3, p331
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mu and kappa opioid receptors often show antagonism in the regulation of physiological responses and behavior, including aggressive behavior. We report here our studies of the effects of acute administration of the selective mu opioid receptor antagonist CTAP (1 and 2 mg/kg, s.c.) and the selective kappa opioid receptor antagonist nor-BNI (0.5 mg/kg, s.c.) on manifestations of aggressive behavior in male C57BL/6 J mice with short (three days) and long (20 days) experience of victory in intermale confrontations. Animals with short experience of aggression were insensitive to blockade of both mu and kappa receptors. In males with long experience of aggression, administration of CTAP led to dose-dependent increases in the latent period of attacks but had no effect on attack duration. Administration of nor-BNI had no effect on the behavior of males with prolonged experience of aggression in antagonistic confrontations. Possible changes in the sensitivity of opioid receptors in male C57BL/6 J mice following prolonged experience of aggression are discussed.
ACCESSION #
94741429

 

Related Articles

  • A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats. Mitchell, Jennifer M.; Liang, Marisa T.; Fields, Howard L. // Psychopharmacology;Nov2005, Vol. 182 Issue 3, p384 

    Rationale: Kappa opioid receptor (KOR) agonists interfere with the reinforcing effects of drugs of abuse. KOR agonists decrease heroin, cocaine, and ethanol self-administration, and block heroin and cocaine conditioned place preference (CPP) in rats. However, KOR agonists also produce emesis and...

  • Effects of μ and δ opioid agonists and antagonists on affective vocal and reflexive pain responses during social stress in rats. Vivian, J. A.; Miczek, Klaus A. // Psychopharmacology;1998, Vol. 139 Issue 4, p364 

    Abstract The present experiments evaluated the influence of intraventricular micro and delta opioid receptors on affective vocal and reflexive responses to aversive stimuli in socially inexperienced, as well as defensive and submissive responses in defeated, adult male Long-Evans rats. Defeat...

  • Lovastatin Delays Infection and Increases Survival Rates in AG129 Mice Infected with Dengue Virus Serotype 2. Martinez-Gutierrez, Marlen; Correa-Londoño, Luis A.; Castellanos, Jaime E.; Gallego-Gómez, Juan C.; Osorio, Jorge E. // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Background: It has been reported that treatment of DENV-infected cultures with Lovastatin (LOV), can affect viral assembly. The objective of this study was to evaluate the effect of LOV on the survival rate and viremia levels of DENV-2-infected AG129 mice. Methodology/Principal Findings: Mice...

  • Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption. Llorente-Berzal, Alvaro; Puighermanal, Emma; Burokas, Aurelijus; Ozaita, Andrés; Maldonado, Rafael; Marco, Eva M.; Viveros, Maria-Paz // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal...

  • You Be the Coder.  // Internal Medicine Coding Alert;Nov2010, Vol. 13 Issue 11, p84 

    The article provides an answer to a question on the calculation of the medications CR Bicillin and Rocephin for tonsillitis.

  • Enfuvirtide has new instructions.  // AIDS Alert;Apr2007, Vol. 22 Issue 4, p44 

    The article reports on the changes made to the instructions in administering enfuvirtide (Fuzeon) distributed by Roche Pharmaceuticals in the U.S.

  • ED.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p723 

    Definitions of the acronym "ED," one of which is effective dose, are presented.

  • ED50.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p723 

    A definition of the term "ED50," which refers to the median effective dose, is presented.

  • F.D.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p853 

    An encyclopedia entry for F.D. which stands for fatal dose is presented.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics