TITLE

Reactive Changes in the Microglia in the Neocortex and Hippocampus in Rats after Acute Prenatal Hypoxia

AUTHOR(S)
Khozhai, L.; Otellin, V.
PUB. DATE
March 2014
SOURCE
Neuroscience & Behavioral Physiology;Mar2014, Vol. 44 Issue 3, p249
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The dynamics of reactive changes in the population density of microgliocytes and the reversibility of their phenotypic forms were studied in the brains of neonatal rats at different time points after acute 1-h exposure to normobaric hypoxia in a barochamber on postnatal day 2. Different parts of the neocortex (frontal, motor, somatosensory, and visual) and segments of the hippocampus (fields CA1, CA3, and CA4 and the dentate fascia) were studied at 1 and 3 h and 1 and 5 days after hypoxia. Microgliocytes were detected immunocytochemically using polyclonal antibodies to Iba-1 antigen. The results showed that the microglial reactions to acute hypoxia in the neocortex and hippocampus in neonates developed simultaneously and synchronously with increases in cell death. Increases in the population density of ameboid microgliocytes in the brain areas of interest occurred within 1 h and resulted from migration of these cells from the subventricular zone and areas adjacent to the major vessels, where they virtually disappeared. The numbers of ameboid microgliocytes in these areas recovered quite quickly (within 3 h). The population density of microgliocytes, especially those of the ameboid form, increased sharply with increases in cell death and lasted to five days.
ACCESSION #
94741422

 

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