Valdoxan (agomelatine) in the Treatment of Depression in Cerebrovascular Diseases (results of the Russian Resonance multicenter naturalistic study)

Pizova, N.
March 2014
Neuroscience & Behavioral Physiology;Mar2014, Vol. 44 Issue 3, p315
Academic Journal
The therapeutic efficacy and tolerance of Valdoxan (agomelatine) in the treatment of mild and moderate depression in cerebrovascular diseases (CVD) in routine neurological practice were evaluated. A total of eight Russian centers took part in the study. The study included 88 patients with CVD (18 men, 70 women) aged 40-65 (mean 55.4 ± 6.5) years. Treatment for six weeks eliminated depressive symptomatology in 81.20% of patients. Patients showed regression of fatigue, improvements in working efficiency, achievement of normal values for the coefficient of mental stability, and improvements in sleep.


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