TITLE

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

AUTHOR(S)
Peng Wang; Hui-Hui Yuan; Xue Zhang; Yun-Ping Li; Lu-Qing Shang; Zheng Yin
PUB. DATE
February 2014
SOURCE
Molecules;Feb2014, Vol. 19 Issue 2, p2469
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
ACCESSION #
94726678

 

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