MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1

Yan, Jiang; Guo, Xiaoqiang; Xia, Jiazeng; Shan, Tin; Gu, Chen; Liang, Zheng; Zhao, Wei; Jin, Shimao
March 2014
Medical Oncology;Mar2014, Vol. 31 Issue 3, p1
Academic Journal
No abstract available.


Related Articles

  • MethlGene Has Progress in Anticancer Programs. Holland-Moritz, Pam // Drug Discovery & Development;Mar2003, Vol. 6 Issue 3, p29 

    Presents updates on the cancer targets DNA methyltransferases and histone deacytelases of Canadian firm MethylGene Inc. Graph on multiple pipeline of novel targets; Use of the targets to play a part in regulating genes and turning off tumor suppressor genes. INSET: Research on Roundworm Genes...

  • Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells. Lee, Yong Joo; Han, Myoung-Eun; Baek, Su-Jin; Kim, Seon-Young; Oh, Sae-Ock // PLoS ONE;7/6/2015, Vol. 10 Issue 7, p1 

    Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and roles...

  • Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Sun, Ming; Xia, Rui; Jin, Feiyan; Xu, Tongpeng; Liu, Zhijun; De, Wei; Liu, Xianghua // Tumor Biology;Feb2014, Vol. 35 Issue 2, p1065 

    Long noncoding RNAs (lncRNAs) have emerged recently as major players in governing fundamental biological processes, and many of which are altered in expression and likely to have a functional role in tumorigenesis. Maternally expressed gene 3 ( MEG3) is an imprinted gene located at 14q32 that...

  • microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Braconi, C; Kogure, T; Valeri, N; Huang, N; Nuovo, G; Costinean, S; Negrini, M; Miotto, E; Croce, C M; Patel, T // Oncogene;11/24/2011, Vol. 30 Issue 47, p4750 

    The human genome is replete with long non-coding RNAs (lncRNA), many of which are transcribed and likely to have a functional role. Microarray analysis of >23 000 lncRNAs revealed downregulation of 712 (∼3%) lncRNA in malignant hepatocytes, among which maternally expressed gene 3 (MEG3) was...

  • Epigenetic roles in the malignant transformation of gastric mucosal cells. Tie, Jun; Zhang, Xiangyuan; Fan, Daiming // Cellular & Molecular Life Sciences;Dec2016, Vol. 73 Issue 24, p4599 

    Gastric carcinogenesis occurs when gastric epithelial cells transition through the initial, immortal, premalignant, and malignant stages of transformation. Epigenetic regulations contribute to this multistep process. Due to the critical role of epigenetic modifications , these changes are highly...

  • Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. Kai-hua Lu; Wei Li; Xiang-hua Liu; Ming Sun; Mei-ling Zhang; Wei-qin Wu; Wei-ping Xie; Ya-yi Hou // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background: Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for understanding the development and progression of cancer. Recently, the...

  • Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers. Yun, Jiyeon; Song, Sang-Hyun; Park, Jinah; Kim, Hwang-Phill; Yoon, Young-Kwang; Lee, Kyung-Hun; Han, Sae-Won; Oh, Do-Youn; Im, Seock-Ah; Bang, Yung-Jue; Kim, Tae-You // Laboratory Investigation (00236837);Jul2012, Vol. 92 Issue 7, p1033 

    Epiregulin (EREG) induces cell growth by binding to the epidermal growth factor receptor (EGFR). Expression of EREG affects sensitivity to cetuximab a chimeric monoclonal antibody that inhibits the EGFR signaling pathway. The mechanism through which EREG is regulated is largely unknown, but a...

  • Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. Weizhao Peng; Shuang Si; Qingxia Zhang; Chaofeng Li; Fang Zhao; Fang Wang; Jia Yu; Ren Ma // Journal of Experimental & Clinical Cancer Research (17569966);Aug2015, Vol. 34 Issue 1, p1 

    Background: Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally expressed gene 3 (MEG3) gene encodes a lncRNA whose expression is lost in an...

  • Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. Tae-Bum Lee; Jung-Hee Park; Young-Don Min; Kyung-Jong Kim; Cheol-Hee Choi // BMC Gastroenterology;2008, Vol. 8, Special section p1 

    Background: The membrane transporters such as P-glycoprotein (Pgp), the MDR1 gene product, are one of causes of treatment failure in cancer patients. In this study, the epigenetic mechanisms involved in differential MDR1 mRNA expression were compared between 10 gastric and 9 colon cancer cell...

  • Association of NDRG1 Gene Promoter Methylation with Reduced NDRG1 Expression in Gastric Cancer Cells and Tissue Specimens. Chang, Xiaojing; Zhang, Shuanglong; Ma, Jinguo; Li, Zhenhua; Zhi, Yu; Chen, Jing; Lu, Yao; Dai, Dongqiu // Cell Biochemistry & Biophysics;May2013, Vol. 66 Issue 1, p93 

    NDRG1 (N-myc downstream-regulated gene 1) plays a role in cell differentiation and suppression of tumor metastasis. This study aims to determine the expression of NDRG1 mRNA and protein in gastric cancer cell lines and tissue specimens and then assess the possible cause of its aberrant...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics