TITLE

Probiotics: effects on immunity

AUTHOR(S)
Isolauri, Erika; Sütas, Yelda; Kankaanpää, Pasi; Arvilommi, Heikki; Salminen, Seppo
PUB. DATE
February 2001
SOURCE
American Journal of Clinical Nutrition;Feb2001, Vol. 73 Issue 2, p444S
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The gastrointestinal tract functions as a barrier against antigens from microorganisms and food. The generation of immunophysiologic regulation in the gut depends on the establishment of indigenous microflora. This has led to the introduction of novel therapeutic interventions based on the consumption of cultures of beneficial live microorganisms that act as probiotics. Among the possible mechanisms of probiotic therapy is promotion of a nonimmunologic gut defense barrier, which includes the normalization of increased intestinal permeability and altered gut microecology. Another possible mechanism of probiotic therapy is improvement of the intestine's immunologic barrier, particularly through intestinal immunoglobulin A responses and alleviation of intestinal inflammatory responses, which produce a gut-stabilizing effect. Many probiotic effects are mediated through immune regulation, particularly through balance control of proinflammatory and anti-inflammatory cytokines. These data show that probiotics can be used as innovative tools to alleviate intestinal inflammation, normalize gut mucosal dysfunction, and down-regulate hyper-sensitivity reactions. More recent data show that differences exist in the immunomodulatory effects of candidate probiotic bacteria. Moreover, distinct regulatory effects have been detected in healthy subjects and in patients with inflammatory diseases. These results suggest that specific immunomodulatory properties of probiotic bacteria should be characterized when developing clinical applications for extended target populations.
ACCESSION #
94427039

 

Related Articles

  • Quality assurance criteria for probiotic bacteria. Tuomola, Elina; Crittenden, Ross; Playne, Martin; Isolauri, Erika; Salminen, Seppo // American Journal of Clinical Nutrition;Feb2001, Vol. 73 Issue 2, p393S 

    Acid and bile stability and intestinal mucosal adhesion properties are among the criteria used to select probiotic microbes. The quality control of probiotic cultures in foods traditionally has relied solely on tests to ensure that an adequate number of viable bacteria are present in the...

  • Gut microbiota-immune-brain interactions in chemotherapy-associated behavioral comorbidities. Jordan, Kelley R.; Loman, Brett R.; Bailey, Michael T.; Pyter, Leah M. // Cancer (0008543X);Oct2018, Vol. 124 Issue 20, p3990 

    Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents...

  • The Gut Microbiota and Healthy Aging: A Mini-Review. Kim, Sangkyu; Jazwinski, S. Michal // Gerontology;Oct2018, Vol. 64 Issue 6, p513 

    The gut microbiota shows a wide inter-individual variation, but its within-individual variation is relatively stable over time. A functional core microbiome, provided by abundant bacterial taxa, seems to be common to various human hosts regardless of their gender, geographic location, and age....

  • In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings. Dunne, Colum; O'Mahony, Liam; Murphy, Lisa; Thornton, Gerardine; Morrissey, Darrin; O'Halloran, Sile; Feeney, Maria; Flynn, Sarah; Fitzgerald, Gerald; Daly, Charles; Kiely, Barry; O'Sullivan, Gerald C.; Shanahan, Fergus; Collins, J. Kevin // American Journal of Clinical Nutrition;Feb2001, Vol. 73 Issue 2, p386S 

    The enteric flora comprises ≈95% of the total number of cells in the human body and can elicit immune responses while protecting against microbial pathogens. However, the resident bacterial flora of the gastrointestinal tract may also be implicated in the pathogenesis of diseases such as...

  • Probiotics in foods not containing milk or milk constituents, with special reference to Lactobacillus plantarum 299v. Molin, Göran // American Journal of Clinical Nutrition;Feb2001, Vol. 73 Issue 2, p380S 

    Lactic acid fermentation is the simplest and safest way of preserving food and has probably always been used by humans. Species such as Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus acidophilus, and Lactobacillus salivarius are common in the human...

  • PROBIOTIC CHOCOLATE RESTORING THE BALANCE.  // Nutraceutical Business & Technology;Mar2011, Vol. 7 Issue 2, p22 

    The article focuses on the importance of probiotics in restoring the balance of intestinal bacteria to improve metabolism and the immune response. It says that probiotic microorganisms should be resistant to the acidic environment of the human digestive system to achieve its beneficial...

  • Probiotic bacteria in fermented foods: product characteristics and starter organisms. Heller, Knut J. // American Journal of Clinical Nutrition;Feb2001, Vol. 73 Issue 2, p374S 

    Probiotic bacteria are sold mainly in fermented foods, and dairy products play a predominant role as carriers of probiotics. These foods are well suited to promoting the positive health image of probiotics for several reasons: 1) fermented foods, and dairy products in particular, already have a...

  • The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial. Wallace, Caroline J.K.; Foster, Jane A.; Soares, Claudio N.; Milev, Roumen V. // Neuropsychobiology;2020, Vol. 79 Issue 1, p108 

    Background: A growing body of evidence has linked mental health outcomes to the gut microbiome. This has led to the investigation of the GI tract as a target for novel treatments and interventions for depression, including probiotic supplementation. Our recent pilot study provided the first...

  • Adenoviruses in Lymphocytes of the Human Gastro- Intestinal Tract. Roy, Soumitra; Calcedo, Roberto; Medina-Jaszek, Angelica; Keough, Martin; Peng, Hui; Wilson, James M. // PLoS ONE;2011, Vol. 6 Issue 9, p1 

    Objective: Persistent adenoviral shedding in stools is known to occur past convalescence following acute adenoviral infections. We wished to establish the frequency with which adenoviruses may colonize the gut in normal human subjects. Methods: The presence of adenoviral DNA in intestinal...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics