Targeting the Wnt pathway in zebrafish as a screening method to identify novel therapeutic compounds

Robertson, Joshua K; Danzmann, Kestral; Charles, Sherise; Blake, Katherine; Olivares, Annia; Bamikole, Solape; Olson, Meghan; Raay, Terence J Van
February 2014
Experimental Biology & Medicine;Feb2014, Vol. 239 Issue 2, p169
Academic Journal
No abstract available.


Related Articles

  • A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling. Gebruers, Evelien; Cordero-Maldonado, María Lorena; Gray, Alexander I.; Clements, Carol; Harvey, Alan L.; Edrada-Ebel, Ruangelie; de Witte, Peter A. M.; Crawford, Alexander D.; Esguerra, Camila V. // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin. We carried out a zebrafish-based phenotypic screen of over 3000 plant-derived secondary metabolite extracts with...

  • Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Wang, Sheng; Yin, Junlin; Chen, Duozhi; Nie, Fen; Song, Xiaomin; Fei, Cong; Miao, Haofei; Jing, Changbin; Ma, Wenjing; Wang, Lei; Xie, Sichun; Li, Chen; Zeng, Rong; Pan, Weijun; Hao, Xiaojiang; Li, Lin // Nature Chemical Biology;Sep2013, Vol. 9 Issue 9, p579 

    The Wnt/β-catenin signaling pathway has a crucial role in embryonic development, stem cell maintenance and human disease. By screening a synthetic chemical library of lycorine derivatives, we identified 4-ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine (HLY78) as an activator of...

  • In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases. Yiyun Zhang; Yeh, J.-R. Joanna // Advances in Hematology;2012, p1 

    In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated. Both high-throughput chemical screening and...

  • The Wnt Pathway as a Target for Small Synthetic Anti-Cancer Molecules. R�hrs, Sonja; M�ller, Oliver // Current Chemical Biology;May2007, Vol. 1 Issue 2, p227 

    The Wnt signaling pathway regulates embryonic development, cell proliferation and cellular morphology. Deregulation and inappropriate activation of the pathway are associated with several diseases including cancer as well as bone and cartilage diseases such as arthritis. The high medical...

  • Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Kawahara, Genri; Gasperini, Molly J.; Myers, Jennifer A.; Widrick, Jeffrey J.; Eran, Alal; Serafini, Peter R.; Alexander, Matthew S.; Pletcher, Mathew T.; Morris, Carl A.; Kunkel, Louis M. // Human Molecular Genetics;Apr2014, Vol. 23 Issue 7, p1869 

    Duchenne muscular dystrophy (DMD) is caused by a lack of the dystrophin protein and has no effective treatment at present. Zebrafish provide a powerful in vivo tool for high-throughput therapeutic drug screening for the improvement of muscle phenotypes caused by dystrophin deficiency. Using the...

  • Natural Compounds as Antagonists of Canonical Wnt/β-Catenin Signaling. Pay Chin Leow; Zhan Yuin Ong; Ee, Pui-Lai Rachel // Current Chemical Biology;Jan2010, Vol. 4 Issue 1, p49 

    Overwhelming evidence that implicates aberrant activations of the canonical Wnt/β-catenin signaling pathway in oncogenesis and cancer progression has emerged in recent times. Accordingly, disruption of this signaling pathway offers an opportunity for effective cancer therapy. Despite various...

  • Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death. Owens, Kelly N.; Santos, Felipe; Roberts, Brock; Linbo, Tor; Coffin, Allison B.; Knisely, Anna J.; Simon, Julian A.; Rubel, Edwin W.; Raible, David W. // PLoS Genetics;Feb2008, Vol. 4 Issue 2, p1 

    Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide. While normal aging is the single greatest contributor, exposure to environmental toxins and therapeutic drugs such as aminoglycoside...

  • Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. Bravo, Dawn T.; Yi-Lin Yang; Kuchenbecker, Kristopher; Ming-Szu Hung; Zhidong Xu; Jablons, David M.; Liang You // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background: Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether...

  • Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos. Sachidanandan, Chetana; Yeh, Jing-Ruey J.; Peterson, Quinn P.; Peterson, Randall T. // PLoS ONE;2008, Vol. 3 Issue 4, p1 

    Small molecules have played an important role in delineating molecular pathways involved in embryonic development and disease pathology. The need for novel small molecule modulators of biological processes has driven a number of targeted screens on large diverse libraries. However, due to the...

  • Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. Sempou, Emily; Biasini, Emiliano; Pinzón-Olejua, Alejandro; Harris, David A.; Málaga-Trillo, Edward // Molecular Neurodegeneration;2/9/2016, Vol. 11, p1 

    Background: Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics