Lactic Acidemia in Infection with Human Immunodeficiency Virus

Carr, Andrew
April 2003
Clinical Infectious Diseases;4/2/2003 Supplement 2, Vol. 36, pS96
Academic Journal
Lactic acidosis in patients infected with the human immunodeficiency virus was initially identified as a rare complication of therapy with nucleoside analog reverse transcriptase inhibitors (NRTIs). The only patient group that appears to be at greater risk is pregnant women. More recently, milder elevations in lactate (i.e., lactic acidemia or hyperlactatemia) have been found to be more common and to be associated with numerous illnesses. Mild asymptomatic lactic acidemia is common, but it appears to lead to more severe illness only rarely. This suggests that routine measurement of plasma lactate should be limited to patients with previous acidemia who reinitiate NRTI therapy and to pregnant women. For symptomatic lactic acidemia (generally >5 mmol/L), NRTIs and other antiretroviral therapy should be ceased. Currently, asymptomatic lactic acidemia should not be treated and should not lead to a change in antiretroviral therapy.


Related Articles

  • Essential cofactors may benefit HIV-infected patients with nucleoside-associated lactic acidosis.  // Kidney;Sep/Oct2002, Vol. 11 Issue 5, p226 

    Presents a summary of the study 'Severe Nucleoside-Associated Lactic Acidosis in Human Immunodeficiency Virus-Infected Patients: Report of 12 Cases and Review of the Literature,' by V. Falc ó et al., from a 2002 issue of 'Clinical Infectious Diseases.'

  • Current Concepts in the Diagnosis and Management of Metabolic Complications of HIV Infection and Its Therapy. Wohl, David A.; McComsey, G.; Tebas, P.; Brown, T. T.; Glesby, M. J.; Reeds, D.; Shikuma, C.; Mulligan, K.; Dube, M.; Wininger, D.; Huang, J.; Revuelta, M.; Currier, J.; Swindells, S.; Fichtenbaum, C.; Basar, M.; Tungsiripat, M.; Meyer, W.; Weihe, J.; Wanke, C. // Clinical Infectious Diseases;9/1/2006, Vol. 43 Issue 5, p645 

    Changes in fat distribution, dyslipidemia, disordered glucose metabolism, and lactic acidosis have emerged as significant challenges to the treatment of human immunodeficiency virus (HIV) infection. Over the past decade, numerous investigations have been conducted to better define these...

  • A Risk-Factor Guided Approach to Reducing Lactic Acidosis and Hyperlactatemia in Patients on Antiretroviral Therapy. Matthews, Lynn T.; Giddy, Janet; Ghebremichael, Musie; Hampton, Jane; Guarino, Anthony J.; Ewusi, Aba; Carver, Emma; Axten, Karen; Geary, Meghan C.; Rajesh T.6Gandhi; Bangsberg, David R. // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    Background: Stavudine continues to be used in antiretroviral treatment (ART) regimens in many resource-limited settings. The use of zidovudine instead of stavudine in higher-risk patients to reduce the likelihood of lactic acidosis and hyperlactatemia (LAHL) has not been examined. Methods:...

  • Distal renal tubular acidosis without renal impairment after use of tenofovir: a case report. Kentaro Iwata; Manabu Nagata; Shuhei Watanabe; Shinichi Nishi // BMC Pharmacology & Toxicology;11/21/2016, Vol. 17, p1 

    Background: Tenofovir, one of antiretroviral medication to treat human immunodeficiency virus (HIV) infection, is known to cause proximal renal tubular acidosis such as Fanconi syndrome, but cases of distal renal tubular acidosis had never been reported. Case presentation: A 20-year-old man with...

  • METHODS FOR MONITORING MITOCHONDRIAL TOXICITY OF NUCLEOSIDE-ANALOGUE REVERSE-TRANSCRIPTASE INHIBITORS IN HIV PATIENTS DURING ANTIRETROVIRAL THERAPY. Tilişcan, C.; Aramă, Victoria; Mihăilescu, Raluca; Streinu-Cercel, A.; Ion, Daniela; Aramă, Ş. S. // Therapeutics, Pharmacology & Clinical Toxicology;Dec2011, Vol. 15 Issue 4, p289 

    Various side effects have been associated to HIV antiretroviral therapy (ART) containing nucleoside reverse transcriptase inhibitors (NRTIs) as a result of mitochondrial toxicity. Mitochondrial DNA (mtDNA) depletion has important clinical consequences: lipodystrophy, hepatic toxicity, lactic...

  • The AIDS challenge. Gloeckner, C. // Current Health 2;Feb1992, Vol. 18 Issue 6, p6 

    Explains how the human immunodeficiency virus (HIV) invades the body, attacks the immune system and eventually causes acquired immunodeficiency syndrome (AIDS). How HIV is spread; Recent retirement of basketball star Earvin `Magic' Johnson; Helper T, or T4, cells; The CD4 receptor; The six...

  • An AIDS timeline: 1840?-2000.  // Current Health 2;Feb1992, Vol. 18 Issue 6, p7 

    Chronicles the worldwide spread of the human immunodeficiency virus (HIV) from approximately 1840 to the year 2000. How HIV spread from apes to humans; The first documented case of acquired immunodeficiency syndrome (AIDS) in 1959; Number of cases in the United States; World Health Organization...

  • AIDS and you.  // Current Health 2;Feb1992, Vol. 18 Issue 6, p9 

    Explains how one can and cannot become infected with the human immunodeficiency virus (HIV). Wet and dry kissing; Blood transfusions; Sexual contact; Condom use; More.

  • How you can--and can't--get infected with HIV.  // Current Health 1;Feb1992, Vol. 15 Issue 6, p11 

    Explains how one can and cannot become infected with the HIV virus. Contact with blood through sex or shared needles; Concern about kissing and medical procedures; Insect bites, sharing a bathroom and so forth.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics