TITLE

The Role of Clonality in the Global Spread of Fluoroquinolone-Resistant Bacteria

AUTHOR(S)
Klugman, Keith P.
PUB. DATE
March 2003
SOURCE
Clinical Infectious Diseases;3/15/2003, Vol. 36 Issue 6, p783
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The molecular epidemiology of fluoroquinolone resistance in a number of bacterial pathogens suggests that the persistence and spread of resistance is associated with a small number of highly successful bacterial clones. The recent description of fluoroquinolone-resistant strains among global clones of pneumococci raises the likelihood that the percentage of pneumococci resistant to fluoroquinolones will increase as this class of agent is increasingly used for the management of respiratory tract infection in adults. Although these clones remain fluoroquinolone susceptible in children, their widespread distribution argues against the extension of fluoroquinolone use to the management of respiratory tract infection in children.
ACCESSION #
9424091

 

Related Articles

  • The Molecular Epidemiology of Streptococcus pneumoniae with Quinolone Resistance Mutations. Richter, S. S.; Heilmann, K. P.; Beekmann, S. E.; Miller, N. J.; Rice, C. L.; Doern, G. V. // Clinical Infectious Diseases;1/15/2005, Vol. 40 Issue 2, p225 

    Background. The purpose of this study was to determine the prevalence of fluoroquinolone resistance and quinolone resistance-determining region (QRDR) mutations among Streptococcus pneumoniae isolates in the United States during the period of 2001-2002. A second objective was to examine the...

  • Telithromycin: A Viewpoint by S. Ragnar Norrby. Norrby, S.R. // Drugs;Apr2001, Vol. 61 Issue 6, p830 

    Comments on the use of telithromycin as an antibiotic against pneumococci. Diseases which can be treated by telithromycin; Effectivity of telithromycin in the oral treatment of respiratory tract infections.

  • Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance. Farrell, David J.; Jenkins, Stephen G.; Brown, Steven D.; Patel, Manish; Lavin, Bruce S.; Klugman, Keith P. // Emerging Infectious Diseases;Jun2005, Vol. 11 Issue 6, p851 

    Streptococcus pneumoniae isolates (N = 31,001) were collected from patients with community-acquired respiratory tract infections during the PROTEKT US surveillance study (2000-2003). While the macrolide (erythromycin) resistance rate remained stable at =29%, the prevalence of resistant isolates...

  • Molecular Epidemiology of Streptococcus pneumoniae Isolates from Children with Recurrent Upper Respiratory Tract Infections. Korona-Glowniak, Izabela; Maj, Maciej; Siwiec, Radosław; Niedzielski, Artur; Malm, Anna // PLoS ONE;7/14/2016, Vol. 11 Issue 7, p1 

    A total of 125 isolates were recovered from adenoids and/or nasopharynx of 170 children aged 2 to 5 from south-east Poland; they had undergone adenoidectomy for recurrent and/or persistent symptoms of upper respiratory tract infections. Pneumococcal isolates were analyzed by phenotyping...

  • Guide to Selection of Fluoroquinolones in Patients with Lower Respiratory Tract Infections. Shams, Wael E.; Evans, Martin E. // Drugs;2005, Vol. 65 Issue 7, p949 

    Newer fluoroquinolones such as levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin have several attributes that make them excellent choices for the therapy of lower respiratory tract infections. In particular, they have excellent intrinsic activity against Streptococcus pneumoniae,...

  • Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine. Eda Suer; Suha Sayrac; Elif Sarinay; Hakan Ozturk; Mustafa Turkoz; Akitoyo Ichinose; Tsuyoshi Nagatake; Kamruddin Ahmed // Journal of Infection & Chemotherapy (Springer Science & Business;Aug2008, Vol. 14 Issue 4, p333 

    Abstract  S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study...

  • In This Issue.  // Clinical Infectious Diseases;10/1/2005, Vol. 41 Issue 7, pi 

    The article presents abstracts of the articles published in the October 2005 issue of the journal "Clinical Infectious Diseases." The article "Control of Penicillin-Nonsusceptible Streptococcus Pneumoniae (PNSP) Carriage" presents information about two intervention strategies to reduce...

  • Reduction of Antibiotic Use in the Community Reduces the Rate of Colonization with Penicillin G- Nonsusceptible Streptococcus pneumoniae. Guillemot, Didier; Varon, Emmanuelle; Bernède, Claire; Weber, Philippe; Henriet, Laurence; Simon, Sylvie; Laurent, Cécile; Lecoeur, Hervé; Carbon, Claude // Clinical Infectious Diseases;10/1/2005, Vol. 41 Issue 7, p930 

    Background. There is a lack of evidence documenting the impact of optimized antibiotic use on the rates of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae (PNSP) in children. This study evaluates the effect of community-based intervention strategies on the prevalence of...

  • Parámetros farmacodinámicos y farmacocinéticos de las fluoroquinolonas respiratorias. Guía para la selección de la fluoroquinolona más apropiada. Parra-Ruiz, Jorge; Hernández-Quero, José // Revista Española de Quimioterapia;dic2012, Vol. 25 Issue 4, p245 

    Since its approval, fluoroquinolones have become one of the most prescribed antibacterial agents. Because of its widespread use, serious concerns about the emergence of resistance in Streptococcus pneumoniae, Pseudomonas spp, and entrobacteriaceae, has arisen, especially because of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics