Gram Stain, Culture, and Histopathological Examination Findings for Heart Valves Removed because of Infective Endocarditis

March 2003
Clinical Infectious Diseases;3/15/2003, Vol. 36 Issue 6, p697
Academic Journal
Retrospective chart review was undertaken for 480 patients who underwent a total of 506 valve replacements or repair procedures for infective endocarditis. The influence of preoperative antimicrobial treatment on culture, Gram stain, and histopathological examination findings for resected valve specimens was examined. When valves were removed before the end of treatment, organisms were seen on the Gram stain of ground valve material performed in the microbiology laboratory and on Gram-stained histopathological sections in 231 (81%) of 285 and 140 (67%) of 208 specimens, respectively (P =.0007). Gram-positive cocci were either cultured from or observed in excised valve tissue in 42 (67%) of 63 episodes involving negative preoperative blood cultures. Positive Gram stain results for microbiological specimens should be reintroduced into the definite pathological criteria for infective endocarditis. When deciding on how long to continue antimicrobial therapy after valve replacement for endocarditis, valve culture results should be the only laboratory finding taken into account, because it takes months for dead bacteria to be removed from sterile vegetations.


Related Articles

  • Dental and Cardiac Risk Factors for Infective Endocarditis. Strom, Brian L.; Abrutyn, Elias // Annals of Internal Medicine;11/15/98, Vol. 129 Issue 10, p761 

    Discusses the risk of bacterial endocarditis from dental treatment and cardiac abnormalities. Link between cardiac valvular abnormalities and endocarditis; Absence of correlation between dental treatment and endocarditis; Cases of infective endocarditis preventable with antibiotic prophylaxis.

  • Damage to the aortic valve as a cause of death in bacterial endocarditis. Cohen, Lawrence; Freedman, Lawrence R.; COHEN, L; FREEDMAN, L R // Annals of Internal Medicine;Oct61, Vol. 55 Issue 4, p562 

    Focuses on valvular deformity as the most common cause of death from bacterial endocarditis at the Grace-New Haven Community Hospital in Connecticut between July 1955 and March 1960. Prognosis of bacterial endocarditis; Absence of correlation between the occurrence of aortic valve injury and...

  • Isolated Pulmonic Valve Endocarditis Caused by Group B Streptococcus (Streptococcus agalactiae). A case Report and Literature Review. Akram, Muhammad; Khan, Ijaz A. // Angiology;Mar2001, Vol. 52 Issue 3, p211 

    Studies an isolated pulmonic valve endocarditis caused by group B streptococcus. Overview of the condition; Predisposing factors; Disease manifestation; Review of literature on isolated pulmonic valve endocarditis.

  • Diagnostic Accuracy of Transthoracic and Multiplane Transesophageal Echocardiography for Valvular... De Castro, Stefano; Cartoni, Domenico; d'Amati, Giulia; Beni, Sergio; Yao, Jiefen; Fiorelli, Marco; Gallo, Pietro; Fedele, Francesco; Pandian, Natesa G. // Clinical Infectious Diseases;5/1/2000, Vol. 30 Issue 5, p825 

    Examines the diagnostic accuracy of transthoracic and multiplane transesophageal echocardiography for assessing valvular perforation during active infective endocarditis. Comparison between transthoracic echocardiography and transesophageal echocardiography's diagnostic sensitivity;...

  • Failure of single dose amoxycillin as prophylaxis against endocarditis. Denning, David W.; Cassidy, Marie; Dougall, Angus; Hillis, W. Stewart // British Medical Journal (Clinical Research Edition);12/1/1984, Vol. 289 Issue 6457, p1499 

    Examines the occurrence of bacterial endocarditis in a patient with valvular disease of the heart following dental clearance. Reason for difficulty in managing the disease; Development of endocarditis with an amoxycillin tolerant strain; Measures to reduce the reservoir of bacteria within the...

  • Aortic Pericardial Heterograft Obstruction from Endocarditis. Lam, Wilfred; Hess, Steven; Eckner, Friedrich; Levitsky, Sidney // Annals of Internal Medicine;Mar1982, Vol. 96 Issue 3, p335 

    Reports a case of bovine pericardial heterograft endocarditis leading to severe valvular obstruction with no regurgitation. Medical history of the patient; Signs and symptoms manifested by the patient; Treatment given.

  • Active infective prosthetic endocarditis after percutaneous edge-to-edge mitral valve repair. Kluge, Jens-Gerrit; Hagendorff, Andreas; Pfeiffer, Dietrich; Jurisch, Daniel; Tarr, Adrienn // European Journal of Echocardiography;2011, Vol. 12 Issue 9, p710 

    No abstract available.

  • Venous Thromboembolic Disease Presenting as Inferior Vena Cava Thrombus Extending into the Right Atrium. Khurana, Anand; Tak, Tahir // Clinical Medicine & Research;May2004, Vol. 2 Issue 2, p125 

    With increasing use of echocardiography, especially transesophageal echocardiography, the diagnosis of intracardiac masses has surged. Masses that are most commonly seen in the atrial chambers include thrombi due to atrial fibrillation, cardiac myxomas often located in the atria, and valvular...

  • Prevalence of infective endocarditis in patients with systemic lupus erythematosus. Miller, Craig S.; Egan, Rita M. // Journal of the American Dental Association (JADA);Mar1999, Vol. 130 Issue 3, p387 

    Determines the association between systemic lupus erythematosus (SLE) with valvulopathy and infective endocarditis (IE). Reported prevalence of IE among patients with SLE; Hemodynamic dysfunction resulting from valvular disease and renal disease in SLE; Undiagnosed cardiac pathoses in patients...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics