TITLE

High Asymmetric Dimethylarginine (ADMA) Levels in Patients with Brucellosis

AUTHOR(S)
Mengeloglu, Zafer; Sünnetcioglu, Mahmut; Tosun, Mehmet; Kücükbayrak, Abdülkadir; Ceylan, Mehmet; Baran, Ali; Karahocagil, Mustafa; Akdeniz, Hayrettin
PUB. DATE
February 2014
SOURCE
Inflammation;Feb2014, Vol. 37 Issue 1, p127
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Asymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls ( P < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that ADMA level ≥0.61 had a sensitivity of 79.5 %, specificity of 88.9 %, positive predictive value of 93.9 %, and negative predictive value of 66.7 %. This is the first report of an association between brucellosis and high levels of ADMA. In conclusion, ADMA levels should be tested in brucellosis cases and that further studies to clarify the mechanism underlying the association between ADMA and brucellosis are required.
ACCESSION #
93921979

 

Related Articles

  • Asymmetric Dimethylarginine, Endothelial Dysfunction and Renal Disease. Aldámiz-Echevarría, Luis; Andrade, Fernando // International Journal of Molecular Sciences;Sep2012, Vol. 13 Issue 9, p11288 

    L-Arginine (Arg) is oxidized to L-citrulline and nitric oxide (NO) by the action of endothelial nitric oxide synthase (NOS). In contrast, protein-incorporated Arg residues can be methylated with subsequent proteolysis giving rise to methylarginine compounds, such as asymmetric dimethylarginine...

  • miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. IANNONE, Lucio; Lan ZHAO; DUBOIS, Olivier; DULUC, Lucie; RHODES, Christopher J.; WHARTON, John; WILKINS, Martin R.; LEIPER, James; WOJCIAK-STOTHARD, Beata // Biochemical Journal;8/15/2014, Vol. 462 Issue 1, following p103 

    The NOS (nitric oxide synthase) inhibitor ADMA (asymmetric dimethylarginine) contributes to the pathogenesis of pulmonary hypertension. Reduced levels of the enzymes metabolizing ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) and increased levels of miR-21 are linked to disease...

  • Asymmetric Dimethyarginine as Marker and Mediator in Ischemic Stroke. Shufen Chen; Na Li; Deb-Chatterji, Milani; Qiang Dong; Kielstein, Jan T.; Weissenborn, Karin; Worthmann, Hans // International Journal of Molecular Sciences;Dec2012, Vol. 13 Issue 12, p15983 

    Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase (NOS) inhibitor, is known as mediator of endothelial cell dysfunction and atherosclerosis. Circulating ADMA levels are correlated with cardiovascular risk factors such as hypercholesterolemia, arterial hypertension, diabetes...

  • DDAH1 Deficiency Attenuates Endothelial Cell Cycle Progression and Angiogenesis. Zhang, Ping; Xu, Xin; Hu, Xinli; Wang, Huan; Fassett, John; Huo, Yuqing; Chen, Yingjie; Bache, Robert J. // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase (NOS). ADMA is eliminated largely by the action of dimethylarginine dimethylaminohydrolase1 (DDAH1). Decreased DDAH activity is found in several pathological conditions and is associated with increased...

  • Ratio Of Serum Asymmetric Dimethyl Arginine (ADMA)/ Nitric Oxide in Coronary Artery Disease patients. SHIVKAR, RAJNI RAJENDRA; ABHANG, SUBODHINI ANANT // Journal of Clinical & Diagnostic Research;Aug2014, Vol. 8 Issue 8, p4 

    Background: Coronary artery disease (CAD) is the leading cause of mortality and morbidity in the world. Current predictions estimate that by the year 2020 cardiovascular diseases, notably atherosclerosis will become the leading global cause of the total disease burden. Atherosclerosis of the...

  • Inflammation impairs eNOS activation by HDL in patients with acute coronary syndrome. Gomaraschi, Monica; Ossoli, Alice; Favari, Elda; Adorni, Maria Pia; Sinagra, Gianfranco; Cattin, Luigi; Veglia, Fabrizio; Bernini, Franco; Franceschini, Guido; Calabresi, Laura // Cardiovascular Research;Oct2013, Vol. 100 Issue 1, p36 

    Aims The aim of the present study was to evaluate the high-density lipoprotein (HDL) structure and endothelial NO synthase (eNOS) activation capacity in ST-elevation myocardial infarction (STEMI) patients with different acute-phase inflammatory response (APR). Methods and results Forty-five...

  • Risk Factors for Normal and High-Tension Glaucoma in Poland in Connection with Polymorphisms of the Endothelial Nitric Oxide Synthase Gene. Kosior-Jarecka, Ewa; Łukasik, Urszula; Wróbel-Dudzińska, Dominika; Kocki, Janusz; Bartosińska, Joanna; Witczak, Agnieszka; Chodorowska, Grażyna; Mosiewicz, Jerzy; Żarnowski, Tomasz // PLoS ONE;1/25/2016, Vol. 11 Issue 1, p1 

    Aim: The purpose of this study was to evaluate the influence of polymorphisms of the eNOS gene on the clinical status of patients with normal and high tension glaucoma. Methods: 266 Polish Caucasian patients with primary open angle glaucoma were studied. Of the 266, 156 had normal tension...

  • Responsiveness of the 24-, 18- and 11-item versions of the Roland Morris Disability Questionnaire. Macedo, Luciana Gazzi; Maher, Chris G.; Latimer, Jane; Hancock, Mark J.; Machado, Luciana A. C.; McAuley, James H. // European Spine Journal;Mar2011, Vol. 20 Issue 3, p458 

    Several versions of the 24-item Roland Morris Disability Questionnaire (RMDQ) have been proposed; however, their responsiveness has not been extensively explored. The objective of this study was to compare the responsiveness of four versions of the RMDQ. Perceived disability was measured using...

  • A model building exercise of mortality risk for Taiwanese women with breast cancer. Chang, Tsai W.; Kuo, Yao L. // BMC Medical Informatics & Decision Making;2010, Vol. 10 Issue 1, p43 

    Background: The accurate estimation of outcome in patients with malignant disease is an essential component of the optimal treatment, decision-making and patient counseling processes. The prognosis and disease outcome of breast cancer patients can differ according to geographic and ethnic...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics