Detection of aberrant hypermethylated spastic paraplegia-20 as a potential biomarker and prognostic factor in gastric cancer

Zhang, Hao; Song, Yongchun; Xia, Peng; Cheng, Yao; Guo, Qi; Diao, Dongmei; Wang, Wei; Wu, Xuandi; Liu, Di; Dang, Chengxue
February 2014
Medical Oncology;Feb2014, Vol. 31 Issue 2, p1
Academic Journal
No abstract available.


Related Articles

  • SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis. Lind, G E; Raiborg, C; Danielsen, S A; Rognum, T O; Thiis-Evensen, E; Hoff, G; Nesbakken, A; Stenmark, H; Lothe, R A // Oncogene;9/15/2011, Vol. 30 Issue 37, p3967 

    Colorectal cancer is a common disease with high mortality. Suitable biomarkers for detection of tumors at an early curable stage would significantly improve patient survival. Here, we show that the SPG20 (spastic paraplegia-20) promoter, encoding the multifunctional Spartin protein, is...

  • Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer. Cheng, Y. Y.; Jin, H.; Liu, X.; Siu, J. M. T.; Wong, Y. P.; Ng, E. K. O.; Yu, J.; Leung, W.-k.; Sung, J. J. Y.; Chan, F. K. L. // British Journal of Cancer;12/16/2008, Vol. 99 Issue 12, p2083 

    Tumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric...

  • Aberrant PTPRO methylation in tumor tissues as a potential biomarker that predicts clinical outcomes in breast cancer patients. Shao-ying Li; Rong Li; Yu-li Chen; Li-kuang Xiong; Hui-lin Wang; Lei Rong; Rong-cheng Luo // BMC Genetics;2014, Vol. 15 Issue 1, p1 

    Background Aberrant hypermethylation of gene promoter regions is a primary mechanism by which tumor suppressor genes become inactivated in breast cancer. Epigenetic inactivation of the protein tyrosine phosphatase receptor-type O gene (PTPRO) has been described in several types of cancer....

  • IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer. Perez-Carbonell, Lucia; Balaguer, Francesc; Toiyama, Yuji; Egoavil, Cecilia; Rojas, Estefania; Guarinos, Carla; Andreu, Montserrat; Llor, Xavier; Castells, Antoni; Jover, Rodrigo; Boland, C. Richard; Goel, Ajay // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Background and Aim: Aberrant hypermethylation of cancer-related genes has emerged as a promising strategy for the development of diagnostic, prognostic and predictive biomarkers in human cancer, including colorectal cancer (CRC). The aim of this study was to perform a systematic and...

  • Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer. Binbin Song; Jiang Ai; Xianghong Kong; Dexin Liu; Jun Li // Pakistan Journal of Medical Sciences;Nov/Dec2013, Vol. 29 Issue 6, p1338 

    Objective: We aimed to explore the association of P16, MGMT and HMLH1 with gastric cancer and their relation with Methylenetetrahydrofolate reductase (MTHFR). Methods: 322 gastric patients who were confirmed with pathological diagnosis were included in our study. Aberrant DNA methylation of P16,...

  • Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer. Hong Zhao; Qinshan Li; Jian Wang; Xianwei Su; Ka Man Ng; Tian Qiu; Ling Shan; Yun Ling; Linfang Wang; Jianqiang Cai; Jianming Ying // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Background: Both gastric and colorectal cancers (CRC) are the most frequently occurring malignancies worldwide with the overall survival of these patients remains unsatisfied. Identification of tumor suppressor genes (TSG) silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis...

  • Incidence and prognostic value of multiple gene promoter methylations in gliomas. Zhang, Longzhou; Wang, Maode; Wang, Wei; Mo, Jun // Journal of Neuro-Oncology;Jan2014, Vol. 116 Issue 2, p349 

    Aberrant CpG island methylation is a common phenomenon in malignancy. The methylation status of multiple tumor suppressor genes may serve as a biomarker for early diagnostics and the prediction of prognosis. In this study, we quantitatively determined the promoter methylation status of five...

  • Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer. Wei, Kuo-Liang; Chou, Jian-Liang; Chen, Yin-Chen; Jin, Hongchuan; Chuang, Yu-Min; Wu, Cheng-Shyong; Chan, Michael W. Y. // PLoS ONE;6/13/2019, Vol. 14 Issue 6, p1 

    Gastric cancer is a leading cause of cancer worldwide. Our previous studies showed that aberrant activation of JAK/STAT3 signaling confer epigenetically silences STAT3 target genes in gastric cancer. To further investigate the clinical significance of this phenomenon, we performed Illumina 850K...

  • miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer. Tan, Zhiqin; Jiang, Hao; Wu, Youhua; Xie, Liming; Dai, Wenxiang; Tang, Hailin; Tang, Sanyuan // Molecular & Cellular Biochemistry;Jan2014, Vol. 386 Issue 1/2, p223 

    miR-185 has been identified as an important factor in several cancers such as breast cancer, ovarial cancer, and prostate cancer. However, its effect and prognostic value in gastric cancer are still poorly known. In this study, we found that the expression levels of miR-185 were strongly...

  • LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. Yuanyuan Zhang; Rui Yang; Jianchun Lian; Haiyan Xu // American Journal of Translational Research;2016, Vol. 8 Issue 11, p5035 

    Sox2 overlapping transcript (Sox2ot) serves as an unfavorable prognostic factor in lung cancer and hepatocellular carcinoma, but the clinical significance and biological function of Sox2ot in gastric cancer is still unknown. The objective of our research is to explore the significance of Sox2ot...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics