TITLE

First detailed reconstruction of the karyotype of Trachypithecus cristatus (Mammalia: Cercopithecidae)

AUTHOR(S)
Fan Xiaobo; Krit Pinthong; Hasmik Mkrtchyan; Pornnarong Siripiyasing; Nadezda Kosyakova; Weerayuth Supiwong; Alongkoad Tanomtong; Arunrat Chaveerach; Liehr, Thomas; de Bello Cioffi, Marcelo; Weise, Anja
PUB. DATE
January 2013
SOURCE
Molecular Cytogenetics (17558166);2013, Vol. 6 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background The chromosomal homologies of human (Homo sapiens = HSA) and silvered leaf monkey (Trachypithecus cristatus = TCR) have been previously studied by classical chromosome staining and by fluorescence in situ hybridization (FISH) applying chromosome-specific DNA probes of all human chromosomes in the 1980s and 1990s, respectively. Results However, as the resolution of these techniques is limited we used multicolor banding (MCB) at an ~250-band level, and other selected human DNA probes to establish a detailed chromosomal map of TCR. Therefore it was possible to precisely determine evolutionary conserved breakpoints, orientation of segments and distribution of specific regions in TCR compared to HSA. Overall, 69 evolutionary conserved breakpoints including chromosomal segments, which failed to be resolved in previous reports, were exactly identified and characterized. Conclusions This work also represents the first molecular cytogenetic one characterizing a multiple sex chromosome system with a male karyotype 44,XY1Y2. The obtained results are compared to other available data for old world monkeys and drawbacks in hominoid evolution are discussed.
ACCESSION #
93538893

 

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