Approaches to the treatment of disease induced by chikungunya virus

Bettadapura, Jayaram; Herrero, Lara J.; Taylor, Adam; Mahalingam, Suresh
November 2013
Indian Journal of Medical Research;Nov2013, Vol. 138 Issue 5, p762
Academic Journal
Chikungunya virus, a re-emerging mosquito-borne alphavirus, causes fever, rash and persistent arthralgia/arthritis in humans. Severe outbreaks have occurred resulting in infections of millions of people in Southeast Asia and Africa. Currently there are no antiviral drugs or vaccines for prevention and treatment of chikungunya infections. Herein we report the current status of research on antiviral drugs and vaccines for chikungunya virus infections.


Related Articles

  • Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose. Roy, Chad J.; Adams, A. Paige; Wang, Eryu; Plante, Kenneth; Gorchakov, Rodion; Seymour, Robert L.; Vinet-Oliphant, Heather; Weaver, Scott C. // Journal of Infectious Diseases;Jun2014, Vol. 209 Issue 12, p1891 

    Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. Currently, there are no vaccines or antivirals available for prevention or treatment. We therefore generated 2 live-attenuated vaccine candidates based on the...

  • Travel-related chikungunya cases in Canada, 2014. Drebot, M. A.; Holloway, K.; Zheng, H.; Ogden, N. H. // Canada Communicable Disease Report;1/8/2015, Vol. 41 Issue 1, p2 

    Since the spring of 2014, there has been a large increase in travel-related chikungunya cases diagnosed in Canada. As of December 9, 2014, 320 confirmed and 159 probable cases have been diagnosed in Canada, with the majority of provinces identifying at least one imported case. This surge in...

  • Chikungunya: out of the tropical forests and heading our way ... Rowland-Jones, Sarah L. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Feb2016, Vol. 110 Issue 2, p85 

    The article offers information on Chikungunya, a disease caused by an alphavirus called chikungunya, which is named from the language of Makonde people in Tanzania which was the first recognized infection in 1952. Chikungunya infection is noted to cause high fever, severe pain and joint swelling...

  • Ross River Virus: Many Vectors and Unusual Hosts Make for an Unpredictable Pathogen. Claflin, Suzi B.; Webb, Cameron E. // PLoS Pathogens;9/3/2015, Vol. 11 Issue 9, p1 

    The article presents information on Ross River virus (RRV). It says that the Alphaviruses, including chikungunya virus (CHIKV), with Ross River virus (RRV), which are endemic to Australia, offer an example of the complexed relationship between vector and reservoir host species across various...

  • Is there a risk of chikungunya transmission in Canada? Ogden, N. H.; Lindsay, L. R.; Coulthart, M. // Canada Communicable Disease Report;1/8/2015, Vol. 41 Issue 1, p11 

    An outbreak of chikungunya virus infection is currently underway in the Caribbean, Central America and South America, and autochthonous (local or indigenous) transmission has occurred in the southeastern United States. The mosquito species known to transmit chikungunya-Aedes aegypti and Aedes...

  • Chikungunya fever in Canada: fever and polyarthritis in a returned traveller. Schwartz, Kevin L.; Giga, Aliyah; Boggild, Andrea K. // CMAJ: Canadian Medical Association Journal;7/8/2014, Vol. 186 Issue 10, p772 

    The article discusses the case of a 28-year old woman from Canada who contracted chikungunya fever during her visit to Mumbai, India. Topics covered include the medical conditions of the patient, the causes, symptoms and treatment of chikungunya fever, and insights on the diagnosis of...

  • Reemergence of Chikungunya Virus in Bo, Sierra Leone. Ansumana, Rashid; Jacobsen, Kathryn H.; Leski, Tomasz A.; Covington, Andrea L.; Bangura, Umaru; Hodges, Mary H.; Lin, Baochuan; Bockarie, Alfred S.; Lamin, Joseph M.; Bockarie, Moses J.; Stenger, David A. // Emerging Infectious Diseases;Jul2013, Vol. 19 Issue 7, p1108 

    We diagnosed 400 possible IgM-positive cases of chikungunya virus in Bo, Sierra Leone, during July 2012--January 2013 by using lateral flow immunoassays. Cases detected likely represent only a small fraction of total cases. Further laboratory testing is required to confirm this outbreak and...

  • Development of a Real-Time Cell Analysing (RTCA) method as a fast and accurate screen for the selection of chikungunya virus replication inhibitors. Marlina, Suria; Meng-Hooi Shu; AbuBakar, Sazaly; Zandi, Keivan // Parasites & Vectors;11/9/2015, Vol. 8 Issue 1, p1 

    Background: The xCELLigence real-time cell analysis (RTCA) system is an established electronic cell sensor array. This system uses microelectronic biosensor technology that is verified for real-time, label-free, dynamic and non-offensive monitoring of cellular features, including detection of...

  • Antiviral activity of silymarin against chikungunya virus. Lani, Rafidah; Hassandarvish, Pouya; Chiam, Chun Wei; Moghaddam, Ehsan; Chu, Justin Jang Hann; Rausalu, Kai; Merits, Andres; Higgs, Stephen; Vanlandingham, Dana; Abu Bakar, Sazaly; Zandi, Keivan // Scientific Reports;6/19/2015, p11421 

    The mosquito-borne chikungunya virus (CHIKV) causes chikungunya fever, with clinical presentations such as severe back and small joint pain, and debilitating arthritis associated with crippling pains that persist for weeks and even years. Although there are several studies to evaluate the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics