TITLE

Thymus and aging: morphological, radiological, and functional overview

AUTHOR(S)
Rezzani, Rita; Nardo, Lorenzo; Favero, Gaia; Peroni, Michele; Rodella, Luigi
PUB. DATE
February 2014
SOURCE
Age;Feb2014, Vol. 36 Issue 1, p313
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aging is a continuous process that induces many alterations in the cytoarchitecture of different organs and systems both in humans and animals. Moreover, it is associated with increased susceptibility to infectious, autoimmune, and neoplastic processes. The thymus is a primary lymphoid organ responsible for the production of immunocompetent T cells and, with aging, it atrophies and declines in functions. Universality of thymic involution in all species possessing thymus, including human, indicates it as a long-standing evolutionary event. Although it is accepted that many factors contribute to age-associated thymic involution, little is known about the mechanisms involved in the process. The exact time point of the initiation is not well defined. To address the issue, we report the exact age of thymus throughout the review so that readers can have a nicely pictured synoptic view of the process. Focusing our attention on the different stages of the development of the thymus gland (natal, postnatal, adult, and old), we describe chronologically the morphological changes of the gland. We report that the thymic morphology and cell types are evolutionarily preserved in several vertebrate species. This finding is important in understanding the similar problems caused by senescence and other diseases. Another point that we considered very important is to indicate the assessment of the thymus through radiological images to highlight its variability in shape, size, and anatomical conformation.
ACCESSION #
93447554

 

Related Articles

  • Effects of Caloric Restriction on Age-Related Hearing Loss in Rodents and Rhesus Monkeys. Someya, Shinichi; Tanokura, Masaru; Weindruch, Richard; Prolla, Tomas A.; Yamasoba, Tatsuya // Current Aging Science;Feb2010, Vol. 3 Issue 1, p20 

    Age-related hearing loss (AHL), also known as presbycusis, is a universal feature of mammalian aging and is the most frequently occurring sensory disorder in the elderly population. AHL is characterized by a decline of auditory function and loss of hair cells and spiral ganglion neurons in the...

  • Oxidative Damage to RNA in Aging and Neurodegenerative Disorders. Nunomura, Akihiko; Moreira, Paula; Castellani, Rudy; Lee, Hyoung-gon; Zhu, Xiongwei; Smith, Mark; Perry, George // Neurotoxicity Research;Oct2012, Vol. 22 Issue 3, p231 

    An age-associated increase in oxidative damage to nucleic acids, predominantly to RNA, has been recently demonstrated in neurons of human and rodent brains, which may play a fundamental role in the development of age-associated neurodegeneration. Indeed, more prominent levels of neuronal RNA...

  • Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. Xiaoyin Wang; Takagawa; Haddad, Daniel J.; Pinnamaneni, Kranthi; Yan Zhang; Sievers, Richard E.; Grossman, William; Yeghiazarians, Yerem; Springer, Matthew L. // Journal of Tissue Science & Engineering;Special2012, Vol. 3 Issue S, Special section p1 

    Therapeutic results of clinical autologous bone marrow cell (BMC) therapy trials for cardiac disease have been modest compared to results of BMC implantation into rodent hearts post-myocardial infarction (MI). In clinical trials, autologous BMCs are typically harvested from older patients who...

  • Citrulline diet supplementation improves specific age-related raft changes in wild-type rodent hippocampus. Marquet-de Rougé, Perrine; Clamagirand, Christine; Facchinetti, Patricia; Rose, Christiane; Sargueil, Françoise; Guihenneuc-Jouyaux, Chantal; Cynober, Luc; Moinard, Christophe; Allinquant, Bernadette // Age;Oct2013, Vol. 35 Issue 5, p1589 

    The levels of molecules crucial for signal transduction processing change in the brain with aging. Lipid rafts are membrane microdomains involved in cell signaling. We describe here substantial biophysical and biochemical changes occurring within the rafts in hippocampus neurons from aging...

  • Immunocytochemical analysis of misplaced rhodopsin-positive cells in the developing rodent retina. Szabó, Klaudia; Szabó, Arnold; Énzsöly, Anna; Szél, Ágoston; Lukáts, Ákos // Cell & Tissue Research;Apr2014, Vol. 356 Issue 1, p49 

    During the first postnatal weeks of the developing rodent retina, rhodopsin can be detected in a number of neuron-like cells in the inner retina. In the present study, we aim to characterize the morphology, number and staining characteristics of this peculiar population. Misplaced...

  • Susceptibility of Some Wild Rodents Widely Distributed in Egyptian Foci to Schistosoma mansoni Infection under Laboratory Conditions. El-Naggar, Sabry A.; Al-Sharkawi, Ismail M.; Madkour, Gamal A. // International Journal of Zoological Research;2011, Vol. 7 Issue 5, p358 

    The most important definitive host of Schistosoma mansoni is the human, however, numerous other mammalian species were found to be infected with this parasite. Among these species, the wild rodents are the most common. In this study, the susceptibility of some wild rodents widely distributed in...

  • Comparative genetics of longevity and cancer: insights from long-lived rodents. Gorbunova, Vera; Seluanov, Andrei; Zhang, Zhengdong; Gladyshev, Vadim N.; Vijg, Jan // Nature Reviews Genetics;Aug2014, Vol. 15 Issue 8, p531 

    Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole...

  • Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages. Prada-Arismendy, Jeanette; Rincón, Verónica; Castellanos, Jaime E. // Journal of Tropical Medicine (16879686);2012, p1 

    Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat,...

  • The Zebrafish Orthologue of the Dyslexia Candidate Gene DYX1C1 Is Essential for Cilia Growth and Function Chandrasekar, Gayathri; Vesterlund, Liselotte; Hultenby, Kjell; Tapia-Páez, Isabel; Kere, Juha // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    DYX1C1, a susceptibility gene for dyslexia, encodes a tetratricopeptide repeat domain containing protein that has been implicated in neuronal migration in rodent models. The developmental role of this gene remains unexplored. To understand the biological function(s) of zebrafish dyx1c1 during...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics