Kaklıkkaya, Neşe; Bayramoğlu, Gülçın; Buruk, Kurtuluş; Tosun, İlknur; Aydın, Faruk
September 2013
Nobel Medicus Journal;Sep-Dec2013, Vol. 9 Issue 3, p116
Academic Journal
Objective: Elevated serum procalcitonin levels are of diagnostic value in most systemic bacterial injections, especially sepsis. However, there are insufficient data on the use of serum procalcitonin levels in the diagnosis of Brucella and Salmonella bacteremia. The aim of this study was to evaluate the diagnostic value of the serum procalcitonin test for Brucella and Salmonella bacteremia. Material and Method: Thirty-one patients with Brucella bacteremia and 12 patients with Salmonella bacteremia were included. The control group consisted of 31 healthy blood donors. Procalcitonin levels were determined with the semiquantitative BRAHMS PCT-Q test using sera from the control subjects and sera from patients obtained concurrently with blood or bone marrow sampling. Results: No detectable procalcitonin (<0.05 ng/mL) was found in 15 (48.4%) of the 31 serafrom patients with Brucellabacteremia. Another 15 (48.4%) had procalcitonin levels between ≥0.05 and <0.5 ng/mL A serum procalcitonin level between ≥0.5 and <2 ng/mL was determined in one patient. Procalcitonin was at detectable levels in all the patients with Salmonella bacteremia. Levels were ≥0.05 and <0.5 in five patients, ≥0.5 and <2 ngl mL in five and ≥2.0 and <10 ng/mL in two. Five (16.1%) of the 31 control samples had procalcitonin levels between ≥0.05 and <0.5 ng/mL, while the remaining 26 (83.9%) had no detectable (<0.05 ng/mL) procalcitonin. Sensitivity and specificity of procalcitonin test for Brucella bacteremia were 3.23% [95% Confidence Interval (CI); 0.54-16.76], 100% (95% CI; 88.68-100), respectively; for Salmonella bacteremia were 58.33% (95% CI; 27.75-84.68), 100% (95% CI; 88.68-100), respectively, with a procalcitonin cut off level of ≥0.5 ng/mL Conclusion: Our results suggested that procalcitonin test is not sensitive enough in diagnosing Brucella bacteremia but it can be tisefull in dismissing the disease. In Salmonella bacteremia the diagnostic value of the procalcitonin test is higher, and therefore the procalcitonin test can be used as a helpful method for diagnosing Salmonella bacteremia.


Related Articles

  • Bone marrow lesions: a universal bone response to injury? Eriksen, Erik; Ringe, Johan // Rheumatology International;Mar2012, Vol. 32 Issue 3, p575 

    The ever increasing use of magnetic resonance imaging in clinical practice has led to the recognition of a new entity, bone marrow lesions (BMLs). These lesions are characterized by excessive water signals in the marrow space and have emerged as a central component of many different diseases...

  • Genetic evaluation of bone marrow-derived mesenchymal stem cells by a modified karyotyping method. Asadi-Yousefabad, Seyedeh-Leili; Khodakaram-Tafti, Azizollah; Dianatpour, Mehdi; Mehrabani, Davood; Zare, Shahrokh; Tamadon, Amin; Nikeghbalian, Saman; Raayat-Jahromi, Alireza; Ahmadlou, Somayeh // Comparative Clinical Pathology;Nov2015, Vol. 24 Issue 6, p1361 

    Bone marrow is the most important source of mesenchymal stem cells (MSCs). Significant development in the comprehension of MSCs biology has opened the way to their clinical use. The object of this study was to establish a method for karyotyping of canine MSCs. We examined the effect of the...

  • HYPOGAMMAGLOBULINEMIA - MAJOR SIGN IN PRIMARY IMMUNODEFICIENCIES DIAGNOSIS. Bataneant, Mihaela // Jurnalul Pediatrului;2015 Supp 3, Vol. 18, p111 

    Hypogammaglobulinemia is defined by decreased gammaglobulins serum level less than 2 SD for age specific normal values, and it can be found at any age. After exclusion of secondary causes, hypogammaglobulinemia represents the major expression for humoral immunodeficiencies or for those with...

  • Neovascularization of ischemic myocardium by human bone-marrow?derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Kocher, A.A.; Schuster, M.D.; Szabolcs, M.J.; Takuma, S.; Burkhoff, D.; Wang, J.; Homma, S.; Edwards, N.M.; Itescu, S. // Nature Medicine;Apr2001, Vol. 7 Issue 4, p430 

    Left ventricular remodeling is a major cause of progressive heart failure and death after myocardial infarction. Although neoangiogenesis within the infarcted tissue is an integral component of the remodeling process, the capillary network is unable to support the greater demands of the...

  • Acute Leukemia.  // Current Medical Literature: Leukemia & Lymphoma;2006, Vol. 14 Issue 3, p67 

    This section presents abstracts of medical research about acute leukemia. They include "A Crosstalk Between the Wnt and the Adhesion-Dependant Signaling Pathways Governs the Chemosensitivity of Acute Myeloid Leukemia," "Implications of NRAS Mutations in AML: A Study of 2502 Patients," and...

  • The epidemiology of extraintestinal non-typhoid Salmonella in Israel: the effects of patients’ age and sex. Zaidenstein, R.; Peretz, C.; Nissan, I.; Reisfeld, A.; Yaron, S.; Agmon, V.; Weinberger, M. // European Journal of Clinical Microbiology & Infectious Diseases;Sep2010, Vol. 29 Issue 9, p1103 

    Extraintestinal disease occurs in 5–8% of non-typhoid Salmonella enterica (NTS) infections and is more likely to be associated with hospitalization and death. The study examined the epidemiology of extraintestinal NTS infections in Israel and the possible effects of patients’ age...

  • Umbilical Cord Blood Offers Another Option for Leukemia Patients. Christensen, Damaris // JNCI: Journal of the National Cancer Institute;2/16/2005, Vol. 97 Issue 4, p253 

    Reports on the transplants that use bone marrow grafts that are mismatched for one antigen or that use stem cell-rich blood taken from umbilical cords soon after birth. Advantages offered by cord blood over bone marrow; Studies that indicate cord blood recipients tended to be younger and sicker...

  • Taliglucerase alfa leads to favorable bone marrow responses in patients with type I Gaucher disease. Mehta, Atul // Current Medical Literature: Lysosomal Storage Disease;2013, Vol. 11 Issue 3, p83 

    The author reflects on the results of a study by L. van Dussen and colleagues concerning the impact of taliglucerase alfa in the bone marrow responses of type 1 Gaucher's disease patients. He discusses how the study was conducted which involved the measurement of bone marrow fat fraction by...

  • Effects of Transplantation with Marrow-Derived Mesenchymal Stem Cells Modified with Survivin on Renal Ischemia-Reperfusion Injury in Mice. Qi Yuzeng; He Weiyang; Gou Xin; Zhou Qingson; Kuang Youlin; Ren Ke // Yonsei Medical Journal;Jun2014, Vol. 55 Issue 4, p1130 

    Purpose: To determine whether renal injury induced by ischemia-reperfusion (I/R) could be further improved by mesenchymal stem cells (MSCs) modified with survivin. Materials and Methods: Lentiviral vectors were used to introduce the survivin gene into MSCs and the MSCs modified with survivin...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics