TITLE

SÄ°STEMÄ°K SKLEROZU OLAN HASTALARDA AORTUN ELASTÄ°K YAPISI Ä°LE PLAZMA ASÄ°METRÄ°K DÄ°METÄ°LARGÄ°NÄ°N (ADMA) ARASINDAKÄ° Ä°LÄ°ÅžKÄ°NÄ°N DEÄžERLENDÄ°RÄ°LMESÄ°

AUTHOR(S)
Arıtürk, Zuhal; Dağ, Şevin; Hbey, M. Ali; Kaya, Hasan; Ertaş, Faruk; Bozkurt, Mehtap; Çevik, Remzi; Uçmak, Derya
PUB. DATE
September 2013
SOURCE
Nobel Medicus Journal;Sep-Dec2013, Vol. 9 Issue 3, p110
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis. Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28 females, mean age 40.7±11.6) and 30 healthy subjects (27 females, mean age 40.6±13). Aortic stiffness was determined with echocardiography. Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53±0.13µmol/l compared with 0.46±0.15 µmol/l for control group. Systolic blood pressure, pulse pressure and aortic 'strain were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic 'strain'. Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort's elastic structure (aortic 'strain', distensibility, and aortic stiffness index).
ACCESSION #
93443863

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics