Yılmaz, Dilek; Sönmez, Ferah; Yenisey, Çığdem; Girişgen, İlknur
September 2013
Nobel Medicus Journal;Sep-Dec2013, Vol. 9 Issue 3, p88
Academic Journal
Objective: Urolithiasis is a multifactorial disease in which both genetic and environmental factors have effects on onset and severity of disease. In this study, the levels of serum 1,25(OH)2D3 in children with urolithiasis and hypercalciuria and the factors affecting it were investigated. Material and Method: A group of forty three children (mean age 8.88±4.62 years, 49% male) diagnosed with urolithiasis and hypercalciuria were included in the study. The study group who had stones in ultrasonography was classified as group 1 and group who had only hypercalciuria, but no stone in ultrasonography was classified as group 2. Twenty three healthy children constituted the control group. In all cases, the serum 1,25(OH)2D3 levels were investigated. Results: 1,25(OH)2D3 levels in group 1 and 2 were significantly higher than the control group. Only 24-hour urine Ca excretion (p=0.000) and 24-hour urine volume (p=0.001) were higher in group 2 than group 1. Conclusion: Increase in active vitamin D might have a role in the pathogenesis of urolithiasis and hypercalciuria.


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