Özdemir, Sebati; Aydın, Ahmet
September 2013
Nobel Medicus Journal;Sep-Dec2013, Vol. 9 Issue 3, p5
Academic Journal
Carnitine is an important essential cofactor in transfer of long chain fatty acids across the inner mitochondrial membrane. In humans, 75% of carnitine is obtained from the diet, and the remainder is endogenously synthesized by kidney, liver and brain. Plasma concentration of free carnitine is in dynamic balance with acylcarnitines with the acyl to free carnitine ration of ≤0.4 being considered normal. Acetyl-L-carnitine is the principal acylcarnitine ester. Acetyl-L-carnitine participates in both anabolic and catabolic pathways in cellular metabolism. It is reported that especially treating minimal hepatic encephalopathy with carnitine exhibited recovery of symptoms and signs of the disease. In this paper, carnitine metabolism and its relations with liver diseases are reviewed.


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