TITLE

Long-Term Moderate Dose Exogenous Erythropoietin Treatment Protects from Intermittent Hypoxia-Induced Spatial Learning Deficits and Hippocampal Oxidative Stress in Young Rats

AUTHOR(S)
Al-Qahtani, Jobran; Abdel-Wahab, Basel; Abd El-Aziz, Samy
PUB. DATE
January 2014
SOURCE
Neurochemical Research;Jan2014, Vol. 39 Issue 1, p161
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exposure to intermittent hypoxia (IH) is associated with cognitive impairments and oxidative stress in brain regions involved in learning and memory. In earlier studies, erythropoietin (EPO) showed a neuroprotective effect in large doses. The aim of the present study was to explore the effect of smaller doses of EPO, such as those used in the treatment of anemia, on IH-induced cognitive deficits and hippocampal oxidative stress in young rats. The effect of concurrent EPO treatment (500 and 1,000 IU/kg/day ip) on spatial learning and memory deficits induced by long-term exposure to IH for 6 weeks was tested using the Morris water maze (MWM) test and the elevated plus maze (EPM) test. Moreover, the effect on hippocampal glutamate and oxidative stress were assessed. Exposure to IH induced a significant impairment of spatial learning and cognition of animals in both MWM and EPM performance parameters. Moreover, hippocampal glutamate and thiobarbituric acid reactive substances (TBARS) increased while antioxidant defenses (GSH and GSH-Px) decreased. EPO in the tested doses significantly reduced the IH-induced spatial learning deficits in both MWM and EPM tests and dose-dependently antagonized the effects of IH on hippocampal glutamate, TBARS, GSH levels, and GSH-Px activity. Treatment with EPO in moderate doses that used for anemia, concurrently with IH exposure can antagonize IH-induced spatial learning deficits and protect hippocampal neurons from IH-induced lipid peroxidation and oxidative stress-induced damage in young rats, possibly through multiple mechanisms involving a potential antioxidative effect.
ACCESSION #
93434889

 

Related Articles

  • Ischemic Postconditioning Alleviates Neuronal Injury Caused by Relief of Carotid Stenosis in a Rat Model of Cerebral Hypoperfusion. Chunsheng Feng; Tianfei Luo; Li Qi; Boyu Wang; Yinan Luo; Pengfei Ge // International Journal of Molecular Sciences;Oct2012, Vol. 13 Issue 10, p13338 

    The effects of early relief of heavy bilateral carotid stenosis and ischemic postconditioning on hippocampus CA1 neurons are still unclear. In this study, we used a rat model to imitate severe bilateral carotid stenosis in humans. The rats were divided into sham group, carotid stenosis group,...

  • Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist Protects Against Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rats. Saad, M.; Abdelsalam, R.; Kenawy, S.; Attia, A. // Neurochemical Research;Jan2015, Vol. 40 Issue 1, p139 

    Cysteinyl leukotrienes (CysLTs) are potent pro-inflammatory and immune modulating lipid mediators involved in inflammatory diseases and were boosted in human brain after acute phase of cerebral ischemia. The antagonism of CysLTs receptors may offer protection against ischemic damage. Therefore...

  • The Functional Effect of Kaempferia Parviflora on Ischemic Stroke in Rats. Phachonpai, Wathita; Maharun, Sinthuporn; Tong-Un, Terdthai; Muchimapura, Supaporn; Wattanathorn, Jintanaporn // American Journal of Agricultural & Biological Science;Apr2012, Vol. 7 Issue 2, p173 

    Problem statement: Oxidative stress has been implicated as important factors in the pathogenesis of cerebral ischemia-induced behavioral deficits particularly memory. Growing attention is being paid to traditional medicinal plants possessing antioxidant activity, as they have been proved...

  • Deprenyl and the Relationship Between Its Effects on Spatial Memory, Oxidant Stress and Hippocampal Neurons in Aged Male Rats. Kiray, M.; Bagriyanik, H. A.; Pekcetin, C.; Ergur, B. U.; Uysal, N.; Ozyurt, D.; Buldan, Z. // Physiological Research;2006, Vol. 55 Issue 2, p205 

    Oxidative stress may play a major role in the aging process and associated cognitive decline. Therefore, antioxidant treatment may alleviate age-related impairment in spatial memory. Cognitive impairment could also involve the age-related morphological alterations of the hippocampal formation....

  • Role of Hippocampal CaMKII in Serotonin 5-HTIA Receptor-Mediated Learning Deficit in Rats. Moyano, Sonia; Del Rio, Joaquin; Frechilla, Diana // Neuropsychopharmacology;Dec2004, Vol. 29 Issue 12, p2216 

    The seroton in 5-HT1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-di-n-propylamino-tetralin), impairs retention performance in a passive avoidance learning task in rats. In the hippocampus of rats trained on this procedure and killed 1 h after the acquisition trial, an increase in the membrane...

  • The Effect of Butter Oil on Avoidance Memory in Normal and Diabetic Rats. Zare, Khadije; Tabatabaei, Seyed Reza Fatemi; Shahriari, Ali; Jafari, Ramezan Ali // Iranian Journal of Basic Medical Sciences;Jul/Aug2012, Vol. 15 Issue 4, p983 

    Objective(s) Since diabetes mellitus is accompanied by cognitive impairment in diabetic patient and animal models and since lipids play important roles in neuronal membrane composition, structure and function; we intended to evaluate the effect of dietary butter oil on passive avoidance memory...

  • A Novel Rattin Expression in The Brain of The Rat Model of Patients' Vascular Dementia. Xinping ZHANG; Qiuling ZHANG; Yifeng DU // Journal of Neurological Sciences;2013, Vol. 30 Issue 2, p249 

    In clinics, the specific mechanism of vascular dementia (VD) was also elusive. So we established VD rat model and explored the pathogenicity. To investigate the effects of Rattin expression in the hippocampus and cerebral cortex of rat's model with vascular VD induced by chronic cerebral...

  • Hypermethylation of Hippocampal Synaptic Plasticity-Related genes is Involved in Neonatal Sevoflurane Exposure-Induced Cognitive Impairments in Rats. Ju, Ling-sha; Jia, Min; Sun, Jie; Sun, Xiao-ru; Zhang, Hui; Ji, Mu-huo; Yang, Jian-jun; Wang, Zhong-yun // Neurotoxicity Research;Feb2016, Vol. 29 Issue 2, p243 

    General anesthetics given to immature rodents cause delayed neurobehavioral abnormalities via incompletely understood mechanisms. DNA methylation, one of the epigenetic modifications, is essential for the modulation of hippocampal synaptic plasticity through regulating the related genes....

  • Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures. Lucas, Marcella M.; Lenck-Santini, Pierre-Pascal; Holmes, Gregory L.; Scott, Rod C. // Brain: A Journal of Neurology;Jun2011, Vol. 134 Issue 6, p1684 

    One of the most common and serious co-morbidities in patients with epilepsy is cognitive impairment. While early-life seizures are considered a major cause for cognitive impairment, it is not known whether it is the seizures, the underlying neurological substrate or a combination that has the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics