TITLE

Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks

AUTHOR(S)
Huber, René; Pietsch, Daniel; Günther, Johannes; Welz, Bastian; Vogt, Nico; Brand, Korbinian
PUB. DATE
January 2014
SOURCE
Cellular & Molecular Life Sciences;Jan2014, Vol. 71 Issue 1, p63
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Monocyte/macrophages are important players in orchestrating the immune response as well as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are characterized by the interplay between expansion of stem/progenitor cells and progression towards further developed (myelo)monocytic phenotypes. In response to a variety of differentiation-inducing stimuli, various prominent signaling pathways are activated. Subsequently, specific transcription factors are induced, regulating cell proliferation and maturation. This review article focuses on the integration of signaling modules and transcriptional networks involved in the determination of monocytic differentiation.
ACCESSION #
93434701

 

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