Elevated CNS inflammation in patients with preclinical Alzheimer's disease

Monson, Nancy L; Ireland, Sara J; Ligocki, Ann J; Chen, Ding; Rounds, William H; Li, Min; Huebinger, Ryan M; Munro Cullum, C; Greenberg, Benjamin M; Stowe, Ann M; Zhang, Rong
January 2014
Journal of Cerebral Blood Flow & Metabolism;Jan2014, Vol. 34 Issue 1, p30
Academic Journal
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.


Related Articles

  • The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. Shaftel, Solomon S.; Griffin, W. Sue T.; O'Banion, M. Kerry // Journal of Neuroinflammation;2008, Vol. 5, Special section p1 

    Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult. The discovery of increased IL-1 levels in patients following acute injury and in chronic neurodegenerative disease laid the foundation for two...

  • A data-driven model of biomarker changes in sporadic Alzheimer's disease. Young, Alexandra L.; Oxtoby, Neil P.; Daga, Pankaj; Cash, David M.; Fox, Nick C.; Ourselin, Sebastien; Schott, Jonathan M.; Alexander, Daniel C. // Brain: A Journal of Neurology;Sep2014, Vol. 137 Issue 9, p2564 

    Young et al. reformulate an event-based model for the progression of Alzheimer's disease to make it applicable to a heterogeneous sporadic disease population. The enhanced model predicts the ordering of biomarker abnormality in sporadic Alzheimer's disease independently of clinical diagnoses or...

  • Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease. Sancheti, Harsh; Akopian, Garnik; Yin, Fei; Brinton, Roberta D.; Walsh, John P.; Cadenas, Enrique // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Alzheimer’s disease is a progressive neurodegenerative disease that entails impairments of memory, thinking and behavior and culminates into brain atrophy. Impaired glucose uptake (accumulating into energy deficits) and synaptic plasticity have been shown to be affected in the early...

  • Directed Network Motifs in Alzheimer’s Disease and Mild Cognitive Impairment. Friedman, Eric J.; Young, Karl; Tremper, Graham; Liang, Jason; Landsberg, Adam S.; Schuff, Norbert; null, null // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Directed network motifs are the building blocks of complex networks, such as human brain networks, and capture deep connectivity information that is not contained in standard network measures. In this paper we present the first application of directed network motifs in vivo to human brain...

  • Enlargement of Cerebral Ventricles as an Early Indicator of Encephalomyelitis. Lepore, Stefano; Waiczies, Helmar; Hentschel, Jan; Ji, Yiyi; Skodowski, Julia; Pohlmann, Andreas; Millward, Jason M.; Paul, Friedemann; Wuerfel, Jens; Niendorf, Thoralf; Waiczies, Sonia // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is...

  • Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease. Mufson, Elliott J.; Ward, Sarah; Binder, Lester // Neurodegenerative Diseases;Jan2014, Vol. 13 Issue 2/3, p151 

    Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. Here, we review data suggesting that prefibrillar tau oligomers mediate cognitive decline early in the disease....

  • Homeostasis of metals in the progression of Alzheimer's disease. González-Domínguez, Raúl; García-Barrera, Tamara; Gómez-Ariza, José // BioMetals;Jun2014, Vol. 27 Issue 3, p539 

    In order to study the involvement of metals in the progression of Alzheimer's disease, serum samples from patients with Alzheimer and mild cognitive impairment were investigated. For this purpose, metal content was analyzed after size-fractionation of species and then, inter-element and...

  • Effect of meditation on cognitive functions in context of aging and neurodegenerative diseases. Marciniak, Rafał; Sheardova, Katerina; Čermáková, Pavla; Hudeček, Daniel; Šumec, Rastislav; Hort, Jakub // Frontiers in Behavioral Neuroscience;Jan2014, Vol. 8, p1 

    Effect of different meditation practices on various aspects of mental and physical health is receiving growing attention. The present paper reviews evidence on the effects of several mediation practices on cognitive functions in the context of aging and neurodegenerative diseases. The effect of...

  • Glutamate in CNS Neurodegeneration and Cognition and its Regulation by GCPII Inhibition. Rahn, K. A.; Slusher, B. S.; Kaplin, A. I. // Current Medicinal Chemistry;Mar/2012, Vol. 19 Issue 9, p1335 

    Glutamate, first identified in 1866, is the primary excitatory neurotransmitter in the brain. While it is critically important in many highly regulated cortical functions such as learning and memory, glutamate can be much like the magic the Sorcerer's Apprentice used in Goethe's poem: when...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics