TITLE

Hereditary hemorrhagic telangiectasia: an update on transforming growth factor � signaling in vasculogenesis and angiogenesis

AUTHOR(S)
van den Driesche, Sander; Mummery, Christine L.; Westermann, Cornelius J.J.
PUB. DATE
April 2003
SOURCE
Cardiovascular Research;Apr2003, Vol. 58 Issue 1, p20
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder in humans which has been mapped to two genes, endoglin and activin receptor-like kinase-1 (ALK-1) both of which mediate signaling by transforming growth factor � ligands in vascular endothelial cells. Animal models have shown that these receptors are not only important for maintaining vascular integrity but also for angiogenesis both during embryonic development and during tumor growth. Here, we review the current status of reported mutations in the context of the clinical manifestations and the effects on the vessel wall both in patients and in animal models of the disease.
ACCESSION #
9343270

 

Related Articles

  • Biological activities of fibroblast growth factor-2 in the adult myocardium. Detillieux, Karen A.; Sheikh, Farah; Kardami, Elissavet; Cattini, Peter A. // Cardiovascular Research;Jan2003, Vol. 57 Issue 1, p8 

    Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions and phenomena, including cell proliferation, differentiation, survival, adhesion, migration, motility and apoptosis, and processes such as limb formation, wound healing, tumorigenesis, angiogenesis,...

  • Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model. Babaei, Saeid; Stewart, Duncan J. // Cardiovascular Research;Jul2002, Vol. 55 Issue 1, p190 

    Objective: Angiogenesis is a complex multistep process that involves endothelial cell (EC) migration, proliferation and differentiation into vascular tubes. NO has been reported to be a downstream mediator in the angiogenic response to a variety of growth factors, but the mechanisms by...

  • ERRATUM.  // Nature Medicine;Mar2000, Vol. 6 Issue 3, p356 

    Presents an erratum for the article 'PR39, a peptide regulator of angiogenesis,' published in the March 2000 issue of 'Nature Medicine,' volume 6, number 3.

  • Polymeric system for dual growth factor delivery. Richardson, Thomas P.; Peters, Martin C.; Ennett, Alessandra B.; Mooney, David J. // Nature Biotechnology;Nov2001, Vol. 19 Issue 11, p1029 

    The development of tissues and organs is typically driven by the action of a number of growth factors. However, efforts to regenerate tissues (e.g., bone, blood vessels) typically rely on the delivery of single factors, and this may partially explain the limited clinical utility of many current...

  • Corrigendum: LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Wang, Xiaomeng; Abraham, Sabu; McKenzie, Jenny A. G.; Jeffs, Natasha; Swire, Matthew; Tripathi, Vineeta B.; Luhmann, Ulrich F. O.; Lange, Clemens A. K.; Zhai, Zhenhua; Arthur, Helen M.; Bainbridge, James W. B.; Moss, Stephen E.; Greenwood, John // Nature;9/26/2013, Vol. 501 Issue 7468, p578 

    A correction to the article "LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling" that was published in the 2013 issue of the periodical is presented.

  • Timeline: VEGF and the quest for tumour angiogenesis factors. Ferrara, Napoleone // Nature Reviews Cancer;Oct2002, Vol. 2 Issue 10, p795 

    The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be central to this process. The quest for VEGF and other factors that promote tumour angiogenesis was...

  • Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway. Clarke, K; Smith, K; Gullick, W J; Harris, A L // British Journal of Cancer;5/15/2001, Vol. 84 Issue 10, p1322 

    Over-expression of truncated epidermal growth factor receptor (EGFR) occurs in a variety of malignancies including glioblastoma multiforme, breast and lung cancer. The truncation deletes an extracellular domain and results in constitutive activation of the receptor. NIH3T3 cells were transfected...

  • Correlation of vascular endothelial growth factor expression with fibroblast growth factor-8 expression and clinico-pathologic parameters in human prostate cancer. West, A F; O’Donnell, M; Charlton, R G; Neal, D E; Leung, H Y // British Journal of Cancer;8/15/2001, Vol. 85 Issue 4, p576 

    Vascular endothelial growth factor (VEGF) mediates neo-angiogenesis during tumour progression and is known to cooperate with the fibroblast growth factor (FGF) system to facilitate angiogenesis in a synergistic manner. In view of this, we have investigated VEGF expression in 67 cases of prostate...

  • Vascular endothelial growth factor A (VEGF-A) mRNA expression levels decrease after menopause in normal breast tissue but not in breast cancer lesions. Greb, R R; Maier, I; Wallwiener, D; Kiesel, L // British Journal of Cancer;9/15/99, Vol. 81 Issue 2, p225 

    We hypothesized that the regulation of microvascular functions and angiogenesis in breast tissue, a well known target of ovarian steroid action, is dependent on the hormonal exposure of the breast. Relative expression levels of VEGF-A (vascular endothelial growth factor A), a putative key...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics