ETV1 positively regulates transcription of tumor suppressor ARF

Zynda, Evan; Jackson, Mark W.; Bhattacharya, Partho; Kandel, Eugene S.
December 2013
Cancer Biology & Therapy;Dec2013, Vol. 14 Issue 12, p1
Academic Journal
No abstract available.


Related Articles

  • Tumorigenesis: OutFOXing liver cancer. Croager, Emma // Nature Reviews Cancer;May2004, Vol. 4 Issue 5, p329 

    Evaluates the importance of the Foxm1b transcription factor for hepatocellular carcinoma development. Increase of Foxm1b expression in hepatocyte nuclei; Regulation of the expression of Cdc25b; Induction of the expression of the tumor suppressor Arf.

  • Arf Induction by Tgfβ Is Influenced by Sp1 and C/ebpβ in Opposing Directions. Zheng, Yanbin; Devitt, Caitlin; Liu, Jing; Iqbal, Nida; Skapek, Stephen X. // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Recent studies show that Arf, a bona fide tumor suppressor, also plays an essential role during mouse eye development. Tgfβ is required for Arf promoter activation in developing mouse eyes, and its capacity to induce Arf depends on Smads 2/3 as well as p38 Mapk. Substantial delay between...

  • Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes. Ayrault, Olivier; Andrique, Laetitia; Larsen, Christian-Jacques; Seite, Paule // Oncogene;10/21/2004, Vol. 23 Issue 49, p8097 

    The tumor suppressor Arf (Alternative Reading Frame) protein (p14ARF in human and p19ARF in mouse) is mainly located in the nucleolus consistent with its subcellular localization, the protein has been shown to specifically interact with 5.8S rRNA and with B23/Nucleophosmin and to regulate...

  • COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer. Mao Ouyang; Hua Wang; Jieyi Ma; Weiming Lü; Jie Li; Chen Yao; Guangqi Chang; Jiong Bi; Shenming Wang; Wenjian Wang // BMC Cancer;2015, Vol. 15 Issue 1, p1 

    Background: ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining...

  • P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3. Zerrouqi, Abdessamad; Pyrzynska, Beata; Febbraio, Maria; Brat, Daniel J.; Van Meir, Erwin G. // Journal of Clinical Investigation;Apr2012, Vol. 122 Issue 4, p1283 

    Malignant gliomas are the most common and the most lethal primary brain tumors in adults. Among malignant gliomas, 60%-80% show loss of P14ARF tumor suppressor activity due to somatic alterations of the INK4A/ARF genetic locus. The tumor suppressor activity of P14ARF is in part a result of its...

  • Methylation Silencing and Mutations of the p14ARF and p16INK4a Genes in Colon Cancer. Burri, Nathalie; Shaw, Phillip; Bouzourene, Hanifa; Sordat, Isabelle; Sordat, Bernard; Gillet, Michel; Schorderet, Daniel; Bosman, Fred T.; Chaubert, Pascal // Laboratory Investigation (00236837);Feb2001, Vol. 81 Issue 2, p217 

    The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle regulation, p16INK4a and p14ARF, whose functions are inactivated in many human cancers. The aim of this study was to evaluate p14ARF and

  • The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice. Rauch, Daniel A.; Hurchla, Michelle A.; Harding, John C.; Deng, Hongju; Shea, Lauren K.; Eagleton, Mark C.; Niewiesk, Stefan; Lairmore, Michael D.; Piwnica-Worms, David; Rosol, Thomas J.; Weber, Jason D.; Ratner, Lee; Weilbaecher, Katherine N. // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    The ARF tumor suppressor regulates p53 as well as basic developmental processes independent of p53, including osteoclast activation, by controlling ribosomal biogenesis. Here we provide evidence that ARF is a master regulator of bone remodeling and osteosarcoma (OS) development in mice. Arf-/-...

  • Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5. Tago, K; Funakoshi-Tago, M; Itoh, H; Furukawa, Y; Kikuchi, J; Kato, T; Suzuki, K; Yanagisawa, K // Oncogene;1/15/2015, Vol. 34 Issue 3, p314 

    Tumor suppressor protein p19ARF (Arf; p14ARF in humans) functions in both p53-dependent and -independent modes to counteract hyper-proliferative signals caused by proto-oncogene activation, but its p53-independent activities remain poorly understood. Using the tandem affinity purification-tag...

  • MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. Chuangui Wang; Ivanov, Alexey; Lihong Chen; Fredericks, William J.; Seto, Ed; Rauscher III, Frank J.; Jiandong Chen // EMBO Journal;9/21/2005, Vol. 24 Issue 18, p3279 

    MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 acetylation, and promotes p53 degradation. Here, we present evidence that MDM2 interacts with the nuclear corepressor KAP1. The...

  • Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Lu, Benson C.; Cebrian, Cristina; Xuan Chi; Kuure, Satu; Kuo, Richard; Bates, Carlton M.; Arber, Silvia; Hassell, John; MacNeil, Lesley; Hoshi, Masato; Jain, Sanjay; Asai, Naoya; Takahashi, Masahide; Schmidt-Ott, Kai M.; Barasch, Jonathan; D'Agati, Vivette; Costantini, Frank // Nature Genetics;Dec2009, Vol. 41 Issue 12, p1295 

    Glial cell line–derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics