Study on Hyperuricemia in HBV-Associated Glomerulonephritis

Yongze Zhuang; Yinghao Yu; Yingfang Huang; Xiaorong Zhong
January 2014
American Journal of Clinical Pathology;Jan2014, Vol. 141 Issue 1, p72
Academic Journal
Objectives: To determine the prevalence and risk factors for hyperuricemia in hepatitis B virus--associated glomerulonephritis (HBV-GN). Methods: Univariate and multivariate logistic regression analysis was applied to decide the risk factors of hyperuricemia in HBV-GN, and clinical and pathologic data were compared between HBV-GN patients with hyperuricemia and those with normal serum uric acid. Results: Among our 227 HBV-GN cases, 31.3% of the patients had hyperuricemia at the time of renal biopsy. Univariate analysis showed that the level of serum creatinine and the severity of glomerular and tubular interstitial injury were significantly related to hyperuricemia. Multivariate logistic regression analysis identified the levels of serum creatinine and tubular interstitial injury as independent factors for hyperuricemia. The incidence of hypertension and lower estimated glomerular filtration rate was significantly higher in hyperuricemic patients with HBV-GN than in normouricemic patients. There were also fewer membranous nephropathy, more proliferative sclerosing glomerulonephritis, and more tubular interstitial injury in hyperuricemic patients with HBV-GN. Conclusions: Our study results suggest that hyperuricemia is common in HBV-GN, which may facilitate the progression of HBV-GN and renal tubular interstitial injury as well as the development of hypertension.


Related Articles

  • ESSENTIAL HYPERTENSION; HYPERURICEMIA IN PATIENTS. Ali Dasti, Mashooq; Ahmed Hashmi, Syed Fasih; Shah, Nisar Ahmed; Hussain, Syed Saad; Gohar, Munaza; Farah, Zul; Ali Shah, Syed Zulfiquar // Professional Medical Journal;2015, Vol. 22 Issue 12, p1555 

    Objectives: To determine the frequency of hyperuricemia in patients with essential hypertension. Study Design: Cross sectional descriptive. Period: Six months study. Setting: Liaquat University Hospital Hyderabad. Patients and Methods: All the patients with essential hypertension visited at...

  • Hepatitis-B virus associated nephropathies: a clinicopathological study in 14 children. Ozdamar, Sukru O.; Gucer, Safak; Tinaztepe, Keriman // Pediatric Nephrology;Jan2003, Vol. 18 Issue 1, p23 

    Hepatitis B virus (HBV)-associated glomerulonephritides have been increasingly reported, and the association between HBV and glomerulopathy is striking, especially in children. In this study, we investigated clinical and immunohistological features of HBV-associated glomerulonephritis in 14...

  • Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy. Jingjing Zhou; Yuqing Chen; Ying Liu; Sufang Shi; Xueying Li; Suxia Wang; Hong Zhang // BMC Nephrology;2014, Vol. 15 Issue 1, p1 

    Background Hyperuricemia appeared to be a common symptom in IgA nephropathy (IgAN), even in those with normal eGFR. IgAN was characterized by variation of pathological features, especially variable tubulointerstitial lesions. Since tubular reabsorption and excretion appeared to be more important...

  • Aggravation of Immunoglobulin A Nephropathy by Hyperuricemia A Mini-Review on Current Findings and New Concepts. Nasri, Hamid; Baradaran, Azar // Iranian Journal of Kidney Diseases;Sep2014, Vol. 8 Issue 5, p359 

    Immunoglobulin A (IgA) nephropathy (IgAN) is the most common form of primary glomerulopathy worldwide. Various investigations have addressed the clinical and morphological risk factors related to the risk of progression. Recently, much attention has been made toward the prognostic implication of...

  • hyperuricemia.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1128 

    A definition of the term "hyperuricemia," which refers to an excessive amount of uric acid in the blood, is presented.

  • Increase in Serum Uric Acid Is Selectively Associated With Stroke in Type 2 Diabetes. Seghieri, Giuseppe; Moruzzo, Daniela; Fascetti, Stefano; Bambini, Clio; Anichini, Roberto; de Bellis, Alessandra; Alviggi, Lorenzo; Franconi, Flavia // Diabetes Care;Jun2002, Vol. 25 Issue 6, p1095 

    Discusses the association of the increase in serum uric acid with stroke in type 2 diabetes. Description of hyperuricemia; Discussion on transient ischemic attack; Analysis of the findings.

  • Gout without hyperuricemia. McCarty, Daniel J. // JAMA: Journal of the American Medical Association;1/26/94, Vol. 271 Issue 4, p302 

    Illustrates the diagnostic and therapeutic misadventures that can occur when acute gout is not considered because of normal uric acid levels. Explanation of pathophysiologic characteristics underlying urate crystal deposition; Physicochemical properties of sodium urate; Definition of...

  • Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. LECOULTRE, VIRGILE; EGLI, L√ČONIE; THEYTAZ, FANNY; DESPLAND, CAMILLE; SCHNEITER, PHILIPPE; TAPPY, LUC // Diabetes Care;Sep2013, Vol. 36 Issue 9, pe149 

    A letter to the editor is presented discussing the association between fructose-induced hyperuricemia with a decreased renal uric acid excretion in humans.

  • Hyperuricemia Possibly Linked to Hematospermia. FREI, ROSEMARY // Renal & Urology News;Jan2014, Vol. 13 Issue 1, p21 

    The article focuses on a study conducted by the researchers from Egypt which suggests the possible association of hematospermia to hyperuricemia.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics