Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)–Affected Areas of China: A Serological Study

Yang, Shigui; Chen, Yu; Cui, Dawei; Yao, Hangping; Lou, Jianzhou; Huo, Zhaoxia; Xie, Guoliang; Yu, Fei; Zheng, Shufa; Yang, Yida; Zhu, Yixin; Lu, Xiaoqing; Liu, Xiaoli; Lau, Siu-Ying; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Chen, Honglin; Li, Lanjuan
January 2014
Journal of Infectious Diseases;Jan2014, Vol. 209 Issue 2, p265
Academic Journal
Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.


Related Articles

  • Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus. Chao Qiu; Yang Huang; Anli Zhang; Di Tian; Yanmin Wan; Xiaoling Zhang; Wanju Zhang; Zhiyong Zhang; Zhenghong Yuan; Yunwen Hu; Xiaoyan Zhang; Jianqing Xu // Emerging Infectious Diseases;Oct2013, Vol. 19 Issue 10, p1685 

    Serologic studies are urgently needed to assist in understanding an outbreak of influenza A(H7N9) virus. However, a biosafety level 3 laboratory is required for conventional serologic assays with live lethal virus. We describe a safe pseudovirus-based neutralization assay with preliminary...

  • Antibodies to Antigenic Site A of Influenza H7 Hemagglutinin Provide Protection against H7N9 Challenge. Schmeisser, Falko; Vasudevan, Anupama; Verma, Swati; Wang, Wei; Alvarado, Esmeralda; Weiss, Carol; Atukorale, Vajini; Meseda, Clement; Weir, Jerry P. // PLoS ONE;Jan2015, Vol. 10 Issue 1, p1 

    Identifying major antigenic and protective epitopes of the H7 hemagglutinin (HA) will be important for understanding the antibody response to vaccines developed against the novel influenza H7N9 viruses that emerged in China in 2013. To facilitate antigenic characterization of the H7N9 HA and to...

  • Human Influenza A(H7N9 Virus Infection Associated with Poultry Farm Northeastern China. Ming Fan; Biao Huang; Ao Wang; Liquan Deng; Donglin Wu; Xinrong Lu; Qinglong Zhao; Shuang Xu; Fiona Havers; Yanhui Wang; Jing Wu; Yuan Yin; Bingxin Sun; Jianyi Yao; Nijuan Xiang // Emerging Infectious Diseases;Nov2014, Vol. 20 Issue 11, p1902 

    We report on a case of human infection with influenza A(H7N9) virus in Jilin Province in northeastern China. This case was associated with a poultry farm rather than a live bird market, which may point to a new focus for public health surveillance and interventions in this evolving outbreak.

  • H7N9 Incident, immune status, the elderly and a warning of an influenza pandemic. Yi Guan; Farooqui, Amber; Huachen Zhu; Wei Dong; Jia Wang; Kelvin, David J. // Journal of Infection in Developing Countries;Apr2013, Vol. 7 Issue 4, p302 

    The novel re-assortment A influenza H7N9 (nrH7N9) emerged in humans in the Shanghai and surrounding provinces of China in late February and early March. Three infected index patients developed severe viral pneumonia with acute respiratory distress syndrome (ARDS) and resulted in fatal outcome....

  • The Neuraminidase Inhibitor Oseltamivir Is Effective Against A/Anhui/1/2013 (H7N9) Influenza Virus in a Mouse Model of Acute Respiratory Distress Syndrome. Baranovich, Tatiana; Burnham, Andrew J.; Marathe, Bindumadhav M.; Armstrong, Jianling; Guan, Yi; Shu, Yuelong; Peiris, Joseph Malik Sriyal; Webby, Richard J.; Webster, Robert G.; Govorkova, Elena A. // Journal of Infectious Diseases;May2014, Vol. 209 Issue 9, p1343 

    Background. High mortality and uncertainty about the effectiveness of neuraminidase inhibitors (NAIs) in humans infected with influenza A(H7N9) viruses are public health concerns.Methods. Susceptibility of N9 viruses to NAIs was determined in a fluorescence-based assay. The NAI oseltamivir (5,...

  • Bird flu in Taiwan.  // Travel Daily;4/29/2013, p7 

    The article reports on the identification of the H7N9 avian influenza in Taiwan.

  • Avian Influenza A(H7N9) Virus Antibodies in Close Contacts of Infected Persons, China, 2013-2014. Mai-Juan Ma; Guang-Yuan Ma; Xiao-Xian Yang; Shan-Hui Chen; Gray, Gregory C.; Teng Zhao; Jing Bao; Jing-Jing Zhou; Yan-Hua Qian; Bin Lu; Xia Ling; Wu-Chun Cao // Emerging Infectious Diseases;Apr2015, Vol. 21 Issue 4, p709 

    The article discusses a study which examined the transmission of avian influenza A (H7N9) virus among several family clusters in China. Particular focus is given to Chinese guidelines on the prevention of human H7N9 virus infection. Also discussed are serum analysis of antibodies against avian...

  • Letter to the Editor: Human infections with avian influenza A(H7N9) in China: preliminary assessments of the age and sex distribution. Viroj Wiwanitkit // Western Pacific Surveillance & Response Journal;2013, Vol. 4 Issue 4, p24 

    A letter to the editor is presented in response to the article "Human Infections With Avian Influenza A(H7N9) in China: Preliminary Assessments of the Age and Sex Distribution" by Y. Arima and colleagues in a 2013 issue.

  • Population immunity to H7N9 very low.  // Infectious Disease News;Jun2013, Vol. 26 Issue 6, p32 

    The article discusses the results of a study which showed a similarity in the immunity of a population to influenza A (H7N9) to that observed for other avian influenzas, with 132 cases of H7N9 reported in China as of June 2013, according to the World Health Organization (WHO).


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics