TITLE

Long non-coding RNA HOTAIR in carcinogenesis and metastasis

AUTHOR(S)
Zhang, Jinsong; Zhang, Peijing; Wang, Li; Piao, Hai-long; Ma, Li
PUB. DATE
January 2014
SOURCE
Acta Biochimica et Biophysica Sinica;Jan2014, Vol. 46 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.
ACCESSION #
93398769

 

Related Articles

  • Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Xiang-hua Liu; Ming Sun; Feng-qi Nie; Ying-bin Ge; Er-bao Zhang; Dan-dan Yin; Rong Kong; Rui Xia; Kai-hua Lu; Jin-hai Li; Wei De1; Ke-ming Wang; Zhao-xia Wang // Molecular Cancer;2014, Vol. 13 Issue 1, p1 

    Background Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of HOTAIR in gastric carcinogenesis remains largely unknown. Methods HOTAIR expression was...

  • Functions of lncRNA HOTAIR in lung cancer. Loewen, Gregory; Jayawickramarajah, Janarthanan; Ying Zhuo; Bin Shan // Journal of Hematology & Oncology;2014, Vol. 7 Issue 1, p110 

    Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor...

  • LINCing chromatin remodeling to metastasis. Croce, Carlo M. // Nature Biotechnology;Sep2010, Vol. 28 Issue 9, p931 

    The article discusses studies on the role of long intergenic noncoding RNA (lincRNA) in tumor metastasis and remodeling of chromatin from the laboratory of researcher Howard Chang. Another discovery is the ability of a noncoding RNA to synchronize the activities of histone-modifying enzymes for...

  • Long noncoding RNA HOTAIR involvement in cancer. Wu, Yansheng; Zhang, Li; Wang, Yang; Li, Hui; Ren, Xiubao; Wei, Feng; Yu, Wenwen; Wang, Xudong; Zhang, Lun; Yu, Jinpu; Hao, Xishan // Tumor Biology;Oct2014, Vol. 35 Issue 10, p9531 

    Evidences have been provided that long noncoding RNAs (lncRNAs) act as key molecules in epigenetic regulation and are involved in the development process of cancer in recent studies. HOX transcript antisense RNA (HOTAIR), a long intergenic noncoding RNA (lincRNA), functions as a molecular...

  • The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance. Zhou, Xiaolong; Chen, Jin; Tang, Wenru // Acta Biochimica et Biophysica Sinica;Dec2014, Vol. 46 Issue 12, p1011 

    Long non-coding RNAs have been reported to play an important role in cellular metabolism and development. Homeobox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA, is pervasively over-expressed in most human cancers compared with non-cancerous adjacent tissues. Although many...

  • The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. Xiang-hua Liu; Zhi-li Liu; Ming Sun; Jing Liu; Zhao-xia Wang; Wei De // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in...

  • A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study. Bayram, Süleyman; Ülger, Yakup; Sümbül, Ahmet; Kaya, Berrin; Rencüzoğulları, Ahmet; Genç, Ahmet; Sevgiler, Yusuf; Bozkurt, Onur; Rencüzoğulları, Eyyüp // Familial Cancer;Dec2015, Vol. 14 Issue 4, p561 

    An aberrant up-regulation of HOX transcript antisense intergenic RNA ( HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778...

  • Long non-coding RNA HOTAIR: A novel oncogene (Review). XIN YU; ZHENG LI // Molecular Medicine Reports;2015, Vol. 12 Issue 4, p5611 

    Long non-coding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and are critical regulators of the epigenome. Increasing evidence suggests that lncRNAs are aberrantly expressed in several types of human cancer and that they are important in the initiation, development...

  • Enhanced Expression of Long Non-Coding RNA HOTAIR Is Associated with the Development of Gastric Cancer. Endo, Hiroyuki; Shiroki, Takeharu; Nakagawa, Takayuki; Yokoyama, Misa; Tamai, Keiichi; Yamanami, Hideaki; Fujiya, Tsuneaki; Sato, Ikuro; Yamaguchi, Kazunori; Tanaka, Nobuyuki; Iijima, Katsunori; Shimosegawa, Tooru; Sugamura, Kazuo; Satoh, Kennichi // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    The long non-coding RNA HOTAIR has been reported to be a poor prognostic biomarker in a variety of malignant tumors. However, little is known about the association of HOTAIR with gastric cancer. We examined the expression of HOTAIR in 68 gastric cancer samples using quantitative real-time RT-PCR...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics