KIAA1462, A Coronary Artery Disease Associated Gene, Is a Candidate Gene for Late Onset Alzheimer Disease in APOE Carriers

Murdock, Deborah G.; Bradford, Yuki; Schnetz-Boutaud, Nathalie; Mayo, Ping; Allen, Melissa J.; D’Aoust, Laura N.; Liang, Xueying; Mitchell, Sabrina L.; Zuchner, Stephan; Small, Gary W.; Gilbert, John R.; Pericak-Vance, Margaret A.; Haines, Jonathan L.
December 2013
PLoS ONE;Dec2013, Vol. 8 Issue 12, p1
Academic Journal
Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, KIAA1462, a gene associated with coronary artery disease, and “rokimi”, encoding an untranslated spliced RNA The genetic architecture at this locus suggests that the gene product important in this association is either “rokimi”, or a different isoform of KIAA1462 than the isoform that is important in cardiovascular disease. Expression data suggests that isoform f of KIAA1462 is a more attractive candidate for association with LOAD in APOE4 carriers than “rokimi” which had no detectable expression in brain.


Related Articles

  • Expanded high-resolution genetic study of 109 Swedish families with Alzheimer's disease. Sillén, Anna; Andrade, Jorge; Lilius, Lena; Forsell, Charlotte; Axelman, Karin; Odeberg, Jacob; Winblad, Bengt; Graff, Caroline // European Journal of Human Genetics;Feb2008, Vol. 16 Issue 2, p202 

    Alzheimer's disease (AD) is a neurodegenerative disease that affects approximately 20 million persons all over the world. There are both sporadic and familial forms of AD. We have previously reported a genome-wide linkage analysis on 71 Swedish AD families using 365 genotyped microsatellite...

  • Gene Electro Transfer of Plasmid Encoding Vascular Endothelial Growth Factor for Enhanced Expression and Perfusion in the Ischemic Swine Heart. Hargrave, Barbara; JrStrange, Robert; Navare, Sagar; Stratton, Michael; Burcus, Nina; Murray, Len; Lundberg, Cathryn; Bulysheva, Anna; Li, Fanying; Heller, Richard // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Myocardial ischemia can damage heart muscle and reduce the heart's pumping efficiency. This study used an ischemic swine heart model to investigate the potential for gene electro transfer of a plasmid encoding vascular endothelial growth factor for improving perfusion and, thus, for reducing...

  • Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Abraham, Richard; Myers, Amanda; Wavrant-DeVrieze, Fabienne; Hamshere, Marian L.; Thomas, Hollie V.; Marshall, Helen; Compton, Danielle; Spurlock, Gillian; Turic, Dragana; Hoogendoorn, Bastiaan; Kwon, Jennifer M.; Petersen, Ronald C.; Tangalos, Eric; Norton, Joanne; Morris, John C.; Bullock, Roger; Liolitsa, Danae; Lovestone, Simon; Hardy, John; Goate, Alison // Human Genetics;Dec2001, Vol. 109 Issue 6, p646 

    Insulin-degrading enzyme (IDE; insulysin; EC is a 110-kDa neutral metallopeptidase that can degrade a number of peptides including β-amyloid. The gene encoding IDE is located on chromosome 10 close to a region of linkage for late-onset Alzheimer's disease (LOAD) and thus is a...

  • Cardiovascular disease prevention and the rise in dementia. Thompson, G.R. // QJM: An International Journal of Medicine;Jan2012, Vol. 105 Issue 1, p93 

    No abstract available.

  • Connecting the Dots: Potential of Data Integration to Identify Regulatory SNPs in Late-Onset Alzheimer's Disease GWAS Findings. Rosenthal, Samantha L.; Barmada, M. Michael; Wang, Xingbin; Demirci, F. Yesim; Kamboh, M. Ilyas // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Late-onset Alzheimer's disease (LOAD) is a multifactorial disorder with over twenty loci associated with disease risk. Given the number of genome-wide significant variants that fall outside of coding regions, it is possible that some of these variants alter some function of gene expression...

  • Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients. Hiltunen, Mikko; Mannermaa, Arto; Koivisto, Anne Maria; Lehtovirta, Maarit; Helisalmi, Seppo; Ryynänen, Markku; Riekkinen, Sr, Paavo; Soininen, Hilkka // European Journal of Human Genetics;Sep99, Vol. 7 Issue 6, p652 

    Alzheimer's disease (AD) is a complex neurodegenerative disorder, for which several diseaseassociated loci have been located on different chromosomes. We have used a population-based linkage disequilibrium mapping approach in order to find potential AD-associated loci on chromosome 13. To avoid...

  • Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss. Su, Mei-Tsz; Lin, Sheng-Hsiang; Lee, I-Wen; Chen, Yi-Chi; Kuo, Pao-Lin // Human Reproduction;Apr2011, Vol. 26 Issue 4, p758 

    BACKGROUND Vascular endothelial growth factor (VEGF) and its kinase insert domain receptor (KDR) play an important role in angiogenesis, and their gene expression patterns also suggest a close relationship with early pregnancy. However, limited information is available regarding the role of the...

  • MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Michaud, Jean-Philippe; Richard, Karine L.; Rivest, Serge // Molecular Neurodegeneration;2011, Vol. 6 Issue 1, p1 

    Background: Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with brain innate immune activation mainly mediated by microglia. These cells are known to be activated in the brain of AD patients and to produce inflammatory cytokines and neurotoxic molecules in...

  • β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology. Liu, Xiaosong; Zhao, Xiaohui; Zeng, Xianglu; Bossers, Koen; Swaab, Dick F; Zhao, Jian; Pei, Gang // Cell Research;Mar2013, Vol. 23 Issue 3, p351 

    Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics