Forward and Backward Inference in Spatial Cognition

Penny, Will D.; Zeidman, Peter; Burgess, Neil
December 2013
PLoS Computational Biology;Dec2013, Vol. 9 Issue 12, p1
Academic Journal
This paper shows that the various computations underlying spatial cognition can be implemented using statistical inference in a single probabilistic model. Inference is implemented using a common set of ‘lower-level’ computations involving forward and backward inference over time. For example, to estimate where you are in a known environment, forward inference is used to optimally combine location estimates from path integration with those from sensory input. To decide which way to turn to reach a goal, forward inference is used to compute the likelihood of reaching that goal under each option. To work out which environment you are in, forward inference is used to compute the likelihood of sensory observations under the different hypotheses. For reaching sensory goals that require a chaining together of decisions, forward inference can be used to compute a state trajectory that will lead to that goal, and backward inference to refine the route and estimate control signals that produce the required trajectory. We propose that these computations are reflected in recent findings of pattern replay in the mammalian brain. Specifically, that theta sequences reflect decision making, theta flickering reflects model selection, and remote replay reflects route and motor planning. We also propose a mapping of the above computational processes onto lateral and medial entorhinal cortex and hippocampus.


Related Articles

  • Multi-voxel pattern analysis in human hippocampal subfields. Bonnici, Heidi M.; Chadwick, Martin J.; Kumaran, Dharshan; Hassabis, Demis; Weiskopf, Nikolaus; Maguire, Eleanor A. // Frontiers in Human Neuroscience;Oct2012, Vol. 6, p1 

    A complete understanding of the hippocampus depends on elucidating the representations and computations that exist in its anatomically distinct subfields. High-resolution structural and functional MRI scanning is starting to permit insights into hippocampal subfields in humans. In parallel, such...

  • Developmental Cell Biology: Communicating with Hedgehogs. Hooper, Joan E.; Scott, Matthew P. // Nature Reviews Molecular Cell Biology;Apr2005, Vol. 6 Issue 4, p306 

    Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different...

  • Interactions between visceral afferent signaling and stimulus processing. Critchley, Hugo D.; Garfinkel, Sarah N.; Spencer, Nick; Changfeng Tai // Frontiers in Neuroscience;Aug2015, p1 

    Visceral afferent signals to the brain influence thoughts, feelings and behavior. Here we highlight the findings of a set of empirical investigations in humans concerning body-mind interaction that focus on how feedback from states of autonomic arousal shapes cognition and emotion. There is a...

  • DISAMBIGUATION OF VISUAL STIMULI CORRELATES WITH ACTIVITY IN BILATERAL MEDIAL TEMPORAL LOBE STRUCTURES. Cirneci, Dragos; Preoteasa, Florentin; Constantinescu, Sorin; Marian, Stelian; Tarta-Arsene, Eugen // Romanian Journal of Neurology;2013, Vol. 12 Issue 1, p15 

    We are organisms adapted to recognise patterns around us in order to avoid ambiguity and indecision and there are inter-individual differences at this level. Ambiguity can be studied in the context of the decision making process, problem solving, perception of images or text comprehension. The...

  • The Role of the Human Entorhinal Cortex in a Representational Account of Memory. Schultz, Heidrun; Sommer, Tobias; Peters, Jan; Giovanello, Kelly; Zeithamova, Dagmar // Frontiers in Human Neuroscience;Nov2015, Vol. 9, p1 

    Connectivity studies in animals form the basis for a representational view of medial temporal lobe (MTL) subregions. In this view, distinct subfields of the entorhinal cortex (EC) relay object-related and spatial information from the perirhinal and parahippocampal cortices (PRC, PHC) to the...

  • Identification of transcriptionally regulated genes in response to cellular iron availability in rat hippocampus. Mei Liu; De-Sheng Xiao; Zhong-Ming Qian // Molecular & Cellular Biochemistry;Jun2007, Vol. 300 Issue 1/2, p139 

    Abstract  The present study was attempted to identify transcriptionally regulated genes of the normal neurocytes responsive to iron availability. Postnatal rat hippocampus cells were primarily cultured either under the iron-loaded or depleted conditions. These cultured cells were applied...

  • Expression changes caused by the peptide semax in the intracellular signal pathway genes in rat hippocamp. Agapova, T. Yu.; Agniullin, Ya. V.; Silachev, D. N.; Shadrina, M. I.; Slominsky, P. A.; Shram, S. I.; Limborskaya, S. A.; Myasoedov, N. F. // Doklady Biochemistry & Biophysics;Nov2007, Vol. 417 Issue 1, p334 

    The article reports on the results of a study of the expression changes caused by the peptide semax in the intracellular signal pathway genes in rat hippocamp. A description of the study design and measurement method is presented. The study showed that semax caused in the hippocampus tissue a...

  • Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling. Mainardi, Marco; Fusco, Salvatore; Grassi, Claudio // Neural Plasticity;4/21/2015, Vol. 2015, p1 

    Hormones and peptides involved in glucose homeostasis are emerging as important modulators of neural plasticity. In this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-I, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus,...

  • FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation. Ahmed, Abdulrzag; de Bock, Charles; Lincz, Lisa; Pundavela, Jay; Zouikr, Ihssane; Sontag, Estelle; Hondermarck, Hubert; Thorne, Rick // Cellular & Molecular Life Sciences;Dec2015, Vol. 72 Issue 23, p4653 

    The Hippo pathway is emerging as a critical nexus that balances self-renewal of progenitors against differentiation; however, upstream elements in vertebrate Hippo signalling are poorly understood. High expression of Fat1 cadherin within the developing neuroepithelium and the manifestation of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics