TITLE

Transformation of Stimulus Correlations by the Retina

AUTHOR(S)
Simmons, Kristina D.; Prentice, Jason S.; Tkačik, Gašper; Homann, Jan; Yee, Heather K.; Palmer, Stephanie E.; Nelson, Philip C.; Balasubramanian, Vijay
PUB. DATE
December 2013
SOURCE
PLoS Computational Biology;Dec2013, Vol. 9 Issue 12, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible.
ACCESSION #
93395135

 

Related Articles

  • Development: Branched for function. Flight, Monica Hoyos // Nature Reviews Neuroscience;Sep2013, Vol. 14 Issue 9, p588 

    The article reports a study on sensory neurons. It mentions their adoption of distinct architecture for responding to stimuli types. It also notes that their fates are recognized through a transcriptional switch which modulates the MEC-3 gene and downstream targets influencing the branching of...

  • Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat. Kage, Karen; Niforatos, Wende; Zhu, Chang Z.; Lynch, Kevin J.; Honore, Prisca; Jarvis, Michael F. // Experimental Brain Research;Dec2002, Vol. 147 Issue 4, p511 

    One subtype of ATP-gated ion channel, the P2X3 receptor, is expressed primarily on peripheral sensory neurons. While it is known that P2X3 receptors can participate in certain forms of nociceptive signaling, their involvement in neuropathic pain transmission is not known. We have examined the...

  • A non-canonical pathway for mammalian blue-green color vision. Sher, Alexander; DeVries, Steven H // Nature Neuroscience;Jul2012, Vol. 15 Issue 7, p952 

    The dynamic range of visual coding is extended by having separate ganglion cell types that respond to light increments and decrements. Although the primordial color vision system in mammals contains a well-characterized ganglion cell that responds to blue light increments (a blue On center...

  • Change point detection for neuronal data with CUSUM and classification methods. Koepcke, Lena; Kretzberg, Jutta // BMC Neuroscience;2013, Vol. 14 Issue Suppl 1, p1 

    An abstract of the article "Change point detection for neuronal data with CUSUM and classification methods" by Lena Koepcke and Jutta Kretzberg is presented.

  • Analysis of Slow (Theta) Oscillations as a Potential Temporal Reference Frame for Information Coding in Sensory Cortices. Kayser, Christoph; Ince, Robin A. A.; Panzeri, Stefano // PLoS Computational Biology;Oct2012, Vol. 8 Issue 10, p1 

    While sensory neurons carry behaviorally relevant information in responses that often extend over hundreds of milliseconds, the key units of neural information likely consist of much shorter and temporally precise spike patterns. The mechanisms and temporal reference frames by which sensory...

  • Another blue neuron in the retina. Masland, Richard H // Nature Neuroscience;Jul2012, Vol. 15 Issue 7, p930 

    The article explores the two complementary reports that identify a new type of amacrine cell whose mechanism for creating a blue-off signal has been entirely missing. One of the reports is recorded from a huge population of retinal ganglion cells using a chip bearing of an array of 512 closely...

  • Investigation of summation mechanisms in the pupillomotor system. Skorkovská, Karolína; Wilhelm, Helmut; Lüdtke, Holger; Wilhelm, Barbara; Kurtenbach, Anne // Graefe's Archive of Clinical & Experimental Ophthalmology;Jul2014, Vol. 252 Issue 7, p1155 

    Background: To ascertain whether the pupillary response amplitude shows spatial summation of responses with increasing size of retinal stimulation, and to examine the pupillary responses for evidence of surround inhibition, analogous to that found in the receptive fields of the retinal ganglion...

  • Working memory and decision processes in visual area V4. Hayden, Benjamin Y.; Gallant, Jack L. // Frontiers in Neuroscience;Feb2013, Vol. 7, p1 

    Recognizing and responding to a remembered stimulus requires the coordination of perception, working memory, and decision-making. To investigate the role of visual cortex in these processes, we recorded responses of single V4 neurons during performance of a delayed match-to-sample task that...

  • A probabilistic framework to infer connectivity from function: a study of change detection and adaptation. Bouaouli, Nabil; Denève, Sophie // BMC Neuroscience;2009 Supplement 1, Vol. 10, Special section p1 

    A marked feature of sensory neurons is their propensity to respond more strongly to transient rather than to steady stimuli. While a variety of mechanisms, like short-term depression and spike rate adaptation, boost responses to higher temporal frequencies, change detection as a key aspect of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics