TITLE

Heterogeneity, Mixing, and the Spatial Scales of Mosquito-Borne Pathogen Transmission

AUTHOR(S)
Perkins, T. Alex; Scott, Thomas W.; Le Menach, Arnaud; Smith, David L.
PUB. DATE
December 2013
SOURCE
PLoS Computational Biology;Dec2013, Vol. 9 Issue 12, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The Ross-Macdonald model has dominated theory for mosquito-borne pathogen transmission dynamics and control for over a century. The model, like many other basic population models, makes the mathematically convenient assumption that populations are well mixed; i.e., that each mosquito is equally likely to bite any vertebrate host. This assumption raises questions about the validity and utility of current theory because it is in conflict with preponderant empirical evidence that transmission is heterogeneous. Here, we propose a new dynamic framework that is realistic enough to describe biological causes of heterogeneous transmission of mosquito-borne pathogens of humans, yet tractable enough to provide a basis for developing and improving general theory. The framework is based on the ecological context of mosquito blood meals and the fine-scale movements of individual mosquitoes and human hosts that give rise to heterogeneous transmission. Using this framework, we describe pathogen dispersion in terms of individual-level analogues of two classical quantities: vectorial capacity and the basic reproductive number, . Importantly, this framework explicitly accounts for three key components of overall heterogeneity in transmission: heterogeneous exposure, poor mixing, and finite host numbers. Using these tools, we propose two ways of characterizing the spatial scales of transmission—pathogen dispersion kernels and the evenness of mixing across scales of aggregation—and demonstrate the consequences of a model's choice of spatial scale for epidemic dynamics and for estimation of , both by a priori model formulas and by inference of the force of infection from time-series data.
ACCESSION #
93395133

 

Related Articles

  • Analysis of post-blood meal flight distances in mosquitoes utilizing zoo animal blood meals. Greenberg, Jacob A.; DiMenna, Mark A.; Hanelt, Ben; Hofkin, Bruce V. // Journal of Vector Ecology;Jun2012, Vol. 37 Issue 1, p83 

    We assessed the post-blood meal flight distance of four mosquito species in a unique environment using blood meal analysis. Mosquitoes were trapped at the Rio Grande Zoo in Albuquerque, NM, and the blood source of bloodengorged mosquitoes was identified. The distance from the enclosure of the...

  • Indoor-Breeding of Aedes albopictus in Northern Peninsular Malaysia and Its Potential Epidemiological Implications. Dieng, Hamady; Saifur, Rahman G. M.; Hassan, Ahmad Abu; Salmah, M. R. Che; Boots, Michael; Satho, Tomomitsu; Jaal, Zairi; AbuBakar, Sazaly // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: The mosquito Ae. albopictus is usually adapted to the peri-domestic environment and typically breeds outdoors. However, we observed its larvae in most containers within homes in northern peninsular Malaysia. To anticipate the epidemiological implications of this indoor-breeding, we...

  • Viral Zoonosis: A Comprehensive Review. Venkatesan, G.; Balamurugan, V.; Gandhale, P. N.; Singh, R. K.; Bhanuprakash, V. // Asian Journal of Animal & Veterinary Advances;2010, Vol. 5 Issue 2, p77 

    Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. Zoonotic pathogens identified are mostly viral origin and are emerging and reemerging. Zoonotic viral infections are grouped based on the type of infection they produce in natural host....

  • Mass mortality in harbour seals and harbour porpoises caused by an unknown pathogen. Harkonen, T.; Bäcklin, B. M.; Barrett, T.; Bergman, A.; Corteyn, M.; Dietz, R.; Harding, K. C.; Malmsten, J.; Roos, A.; Teilmann, J. // Veterinary Record: Journal of the British Veterinary Association;4/26/2008, Vol. 162 Issue 17, p555 

    The article discusses the epidemiology, clinical and histopathological findings, and the virological and bacteriological investigations results from the 2007 epidemic on seals. It suggests that the unknown pathogen was most likely a virus and that there is a risk that the disease may spread to...

  • The Epidemiology of Tinea Manuum in Nanchang Area, South China. Zhan, Ping; Geng, Chengfang; Li, Zhihua; Jiang, Qing; Jin, Yun; Li, Caixia; Liu, Weida // Mycopathologia;Aug2013, Vol. 176 Issue 1/2, p83 

    Tinea manuum is a common superficial fungal infection which is usually coexistent with tinea pedis; there are few studies available on the epidemiology of tinea manuum at present. This study aims to investigate the epidemiology of tinea manuum and its correlation with tinea pedis in south China....

  • Ecologic Niche Modeling and Spatial Patterns of Disease Transmission. Townsend Peterson, A. // Emerging Infectious Diseases;Dec2006, Vol. 12 Issue 12, p1822 

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned with the geography, or potential geography, of vectors, hosts,...

  • Pathogen transmission and clinic scheduling. Hotchkiss, John R.; Strike, David G.; Crooke, Philip S. // Emerging Infectious Diseases;Jan2006, Vol. 12 Issue 1, p159 

    We developed a model of pathogen dissemination in the outpatient clinic that incorporates key kinetic aspects of the transmission process, as well as uncertainty regarding whether or not each incident patient is contagious. Assigning appointments late in the day to patients suspected of being...

  • Implications of Host Genetic Variation on the Risk and Prevalence of Infectious Diseases Transmitted Through the Environment. Doeschl-Wilson, Andrea B.; Davidson, R.; Conington, J.; Roughsedge, T.; Hutchings, M. R.; Villanueva, B. // Genetics;Jul2011, Vol. 188 Issue 3, p683 

    Previous studies have shown that host genetic heterogeneity in the response to infectious challenge can affect the emergence risk and the severity of diseases transmitted through direct contact between individuals. However, there is substantial uncertainty about the degree and direction of...

  • Family clustering of Viliuisk encephalomyelitis in traditional and new geographic regions. Vladimirtsev, Vsevolod A.; Nikitina, Raisa S.; Renwick, Neil; Ivanova, Anastasia A.; Danilova, Al'bina P.; Platonov, Fyodor A.; Krivoshapkin, Vadim G.; McLean, Catriona A.; Masters, Colin L.; Gajdusek, D. Carleton; Goldfarb, Lev G. // Emerging Infectious Diseases;Sep2007, Vol. 13 Issue 9, p1321 

    Viliuisk encephalomyelitis is an acute, often fatal, meningoencephalitis that tends to develop into a prolonged chronically progressive panencephalitis. Clinical, neuropathologic, and epidemiologic data argue for an infectious cause, although multiple attempts at pathogen isolation have been...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics