TITLE

Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis

AUTHOR(S)
Hung, Chao-Hung; Lu, Sheng-Nan; Wang, Jing-Houng; Lee, Chuan-Mo; Chen, Tsung-Ming; Tung, Hung-Da; Chen, Chien-Hung; Huang, Wu-Shiung; Changchien, Chi-Sin
PUB. DATE
February 2003
SOURCE
Journal of Gastroenterology;2003, Vol. 38 Issue 2, p153
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. We aimed to evaluate the validity of ultrasonography (US) in the diagnosis of cirrhosis in patients with chronic hepatitis B virus (HBV) or C virus (HCV) infection. Methods. A total of 210 patients, 67 with chronic HBV and 143 with HCV infection, were evaluated for the cirrhotic status of liver by both needle biopsy and US. According to the pathological findings, a fibrosis score 4 on the histology activity index was the gold standard for the diagnosis of cirrhosis. A US scoring system consisting of liver surface, parenchyma, vascular structure, and splenic size was used to describe the severity of hepatic parenchymal damage. Results. Cirrhosis was found in 27 (40%) of the 67 HBV patients and in 51 (36%) of the 143 HCV patients pathologically. The mean fibrosis scores were 0.95, 1.24, 2.35, 2.95, 3.8 and 3.7 in patients with US scores of 4, 5, 6, 7, 8, and 9 or more, respectively. The US scores were significantly correlated with the hepatic fibrosis scores (P < 0.05). Based on the receiver operating characteristic (ROC) curve, a US score of 7 was the best cutoff point for the prediction of HBV-related cirrhosis, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 77.8%, 92.5%, 87.5%, 86.0%, and 86.6%, respectively. In HCV-related cirrhosis, a US score of 6 provided results of 82.4%, 70.7%, 60.9%, 87.8%, and 74.8%, respectively. The specificity, positive predictive value, and accuracy were significantly higher in patients with HBV than in those with HCV infection (P = 0.012, P = 0.032, and P = 0.079, respectively). Conclusions. Cirrhosis can be predicted well by US, especially in patients with HBV infection.
ACCESSION #
9309606

 

Related Articles

  • Predictive Factors for Hepatocellular Carcinoma in Type 1 Autoimmune Hepatitis. Montano-Loza, Aldo J.; Carpenter, Herschel A.; Czaja, Albert J. // American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p1944 

    OBJECTIVE: Hepatocellular carcinoma (HCC) is an uncommon but serious occurrence in autoimmune hepatitis. Our objective was to determine predictors for this neoplasm to improve screening strategies. METHODS: Two hundred twenty-seven patients underwent hepatic ultrasonography and serum alpha...

  • Simultaneous Measurements of Serum α-Fetoprotein and Protein Induced by Vitamin K Absence for Detecting Hepatocellular Carcinoma. Ishii, Motoyasu; Gama, Hiroko; Chida, Nobuyuki; Ueno, Yoshiyuki; Shinzawa, Haruhide; Takagi, Tooru; Toyota, Takayoshi; Takahashi, Tsuneo; Kasukawa, Reiji // American Journal of Gastroenterology;Apr2000, Vol. 95 Issue 4, p1036 

    OBJECTIVE: We evaluated the measurements of serum α-fetoprotein (AFP) and the protein induced by vitamin K absence (PIVKA-II) in 734 patients with chronic hepatitis (CH) and liver cirrhosis (LC) who had been followed-up tor the development of hepatocellular carcinoma (HCC). METHODS: Serum AFP...

  • Prevalencia de la hepatitis por virus B en pacientes con cirrosis en México. Abdo-Francis, Miguel; Torre, Aldo; Tenorio, Ceriolith; Ornelas, Edwin; Villasis, Angelina // Revista Medica del Hospital General de Mexico;ene-mar2011, Vol. 74 Issue 1, p16 

    Introduction: Liver cirrhosis is one of the five main causes of death in Mexico; alcohol ingestion and viral pathologies are the most frequent etiologies. Objective: The aim of the present study was to evaluate the prevalence of Hepatitis B in patients with liver cirrhosis in Mexico. Methods: A...

  • Ultrasound screening for hepatocellular carcinoma in patients with advanced liver fibrosis. An overview. Dănilă, Mirela; Sporea, Ioan // Medical Ultrasonography;Jun2014, Vol. 16 Issue 2, p139 

    Liver cirrhosis is the major risk factor for hepatocellular carcinoma (HCC). All etiologic forms of liver cirrhosis may be complicated by HCC but the risk is higher in patients with hepatitis B or C viral infection. Patients at high risk for developing HCC should be included in surveillance...

  • FREQUENCY OF HEPATOCELLULAR CARCINOMA IN CIRRHOSIS. Amin, Said; Shabbier, Ghulam; Ul Haq, Anwar; Wazir, Muhammad Noor // Professional Medical Journal;Jan/Feb2012, Vol. 19 Issue 1, p73 

    Objective: To find the frequency of hepatocellular carcinoma in cirrhotic patients of our population. Design: Prospective observational study. Setting: Medical A Unit Hayat Abad Medical Complex Peshawar. Period: 1st January 2010 to 31st July 2011. Material & methods: All patients were screened...

  • Seizures associated with local anaesthetic intoxication. Landy, C.; Gagnon, N.; Boulland, P.; Raynaud, L.; Plancade, D. // BJA: The British Journal of Anaesthesia;Sep2012, Vol. 109 Issue 3, p463 

    No abstract available.

  • Noninvasive diagnostic method for idiopathic portal hypertension based on measurements of liver and spleen stiffness by ARFI elastography. Furuichi, Yoshihiro; Moriyasu, Fuminori; Taira, Junichi; Sugimoto, Katsutoshi; Sano, Takatomo; Ichimura, Shigeki; Miyata, Yuki; Imai, Yasuharu // Journal of Gastroenterology;Sep2013, Vol. 48 Issue 9, p1061 

    Background: Acoustic radiation force impulse (ARFI) elastography is an ultrasound technique that is capable of measuring tissue stiffness noninvasively. It is difficult to differentiate idiopathic portal hypertension (IPH) from liver cirrhosis (LC) or chronic hepatitis (CH), and liver biopsy is...

  • Liver elastography for the diagnosis of portal hypertension in patients with liver cirrhosis. Şirli, Roxana; Sporea, Ioan; Bota, Simona; Raţiu, Iulia // Medical Ultrasonography;Sep2012, Vol. 14 Issue 3, p225 

    Progressive hepatic fibrosis is a feature of almost all chronic liver diseases. In their final stage, advanced cirrhosis, the clinical signs are diagnostic, but compensated liver cirrhosis is not always easy to diagnose. Apart from liver biopsy, serologic and elastographic non invasive methods...

  • Acoustic Structure Quantification (ASQ) Software in Estimating the Degree of Liver Fibrosis of Chronic Hepatitis B. LI Ming-ming; ZHU Mei // Journal of Kunming Medical University / Kunming Yike Daxue Xueba;2014, Vol. 35 Issue 8, p54 

    Objective To assess the diagnostic accuracy of acoustic structure quantification ( ASQ) ultrasound software in estimating the degree of liver fibrosis of chronic hepatitis B. Methods We selected 66 patients with histologically proven chronic hepatitis B virus, who were examined by B-Mode...

  • Missed Opportunities for Hepatocellular Carcinoma Screening in an HIV/Hepatitis C Virus–Coinfected Cohort. Beauchamp, Elizabeth; Rollet, Kathleen; Walmsley, Sharon; Wong, David K.; Cooper, Curtis; Klein, Marina B. // Clinical Infectious Diseases;Nov2013, Vol. 57 Issue 9, p1339 

    We examined adherence to guidelines for screening of hepatocellular carcinoma in a cohort of HIV/hepatitis C virus–coinfected patients. Thirty-six percent of patients with documented cirrhosis did not have a screening ultrasound. Patients at centers with standardized systems for screening...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics