Antitumor Activity of Magnetite Nanoparticles: Influence of Hydrocarbonated Chain of Saturated Aliphatic Monocarboxylic Acids

Voicu, Georgeta; Andronescu, Ecaterina; Grumezescu, Alexandru Mihai; Keng-Shiang Huang; Ficai, Anton; Chih-Hui Yang; Bleotu, Coralia; Chifiriuc, Mariana Carmen
April 2013
Current Organic Chemistry;Apr2013, Vol. 17 Issue 7/8, p831
Academic Journal
Nanomaterial drug delivery systems are promising vehicles to improve chemotherapy and decrease side effects. In the lastyears, there have been more reports published in prestigious journals addressing the successful application of magnetite nanoparticles intumors treatment. The antitumor effect of magnetic fluids was studied intensely by applying an external magnetic field to retain thenanoparticles in the tumor tissue, and also to help regulating the release of loaded drugs. These features make them more competitive as adrug carrier than other nanomaterials. In addition, the MRI (magnetic resonance imaging) property of magnetic nanomaterials can enhancethe monitoring of drug carriers locations. In all cases, the tumor significantly regressed in size and the microscopic exam revealedthat the tumor cells massively endocytosed magnetic nanoparticles and entered in lysis process. Although the functionalization of nano particles generally refers to the addition of a polar shell to increase their solubility on the human body liquids, we have demonstratedthat nanomaterials based magnetite functionalized with different types of fatty acids could exhibit antitumor properties without applyingany external alternating magnetic field, when tested in vitro, on HEp-2 cells.


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