The emerging science of body weight regulation and its impact on obesity treatment
Tags: OBESITY; BODY weight; LEPTIN; GENES
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- An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. McMinn, Julie; Liu, Shun-Mei; Dragatsis, Ioannis; Dietrich, Paula; Ludwig, Thomas; Eiden, Sandra; Chua, Jr., Streamson // Mammalian Genome;Sep2004, Vol. 15 Issue 9, p677
Body weight regulation is mediated through several major signaling pathways, some of which have been delineated by positional cloning of spontaneous genetic mutations in mice.Lepr db/db mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive...
- Unraveling the central nervous system pathways underlying responses to leptin. Elmquist, Joel K.; Maratos-Flier, Eleftheria; Saper, Clifford B.; Flier, Jeffrey S. // Nature Neuroscience;Oct98, Vol. 1 Issue 6, p445
Here we summarize recent progress in the biology of leptin, concentrating on its central nervous system (CNS) actions. The product of the ob gene, leptin is a circulating hormone produced by white adipose tissue that has potent effects on feeding behavior, thermogenesis and neuroendocrine...
- Neurobiology of obesity. Markus, Annette // Nature Neuroscience;May2005, Vol. 8 Issue 5, p551
Investigates the neurobiology of obesity. Response of the hypothalamic melanocortin system to hormones and nutrients; Assessment of the genetic cause of inherited obesity; Contribution of high leptin levels to leptin resistance in obesity.
- Obesity Part two -- The biology of body weight regulation. Speakman, John R. // Biologist;Apr2003, Vol. 50 Issue 2, p69
Part II. Focuses on obesity and the regulation of food intake, energy expenditure and body mass. Information on lipostat; Discussion of the lipostatic regulation system; Potential of leptin as a therapeutic agent for the treatment of obesity.
- Hepatic Gene Expression Profiling Reveals Key Pathways Involved in Leptin-Mediated Weight Loss in ob/ob Mice. Sharma, Ashok; Bartell, Shoshana M.; Baile, Clifton A.; Bo Chen; Podolsky, Robert H.; McIndoe, Richard A.; Jin-Xiong She // PLoS ONE;2010, Vol. 5 Issue 8, p1
Background: Leptin, a cytokine-like protein, plays an important role in the regulation of body weight through inhibition of food intake and stimulation of energy expenditure. Leptin circulates in blood and acts on the brain, which sends downstream signals to regulate body weight. Leptin therapy...
- Munchies after menopause. McVeigh, Gloria // Prevention;May2004, Vol. 56 Issue 5, p82
Reports on the increased appetite among women during menopause, according to researchers from Oregon Health & Science University. Relationship between leptin levels and obesity in both monkeys and humans; Importance of body weight for women going into menopause.
- Of Mice and Mass. Neporent, Liz // Joe Weider's Muscle & Fitness Hers;Nov2003, Vol. 4 Issue 8, p112
Deals with the link between leptin and obesity, based on studies conducted on mice. Role of leptin in regulating body fat; Impact of weight loss on leptin levels and leptin resistance.
- The Future of Weight Management. Meisler, Jodi Godfrey // Journal of Women's Health & Gender-Based Medicine;Sep99, Vol. 8 Issue 7, p889
The article looks at the range of issues explored in the seminar "The Future of Weight Management." For body weight and body fat stores to remain stable over time, caloric intake and energy expenditure must be matched. Early investigators conducted studies that demonstrated that by trying to...
- Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Howard, Jane K; Cave, Belinda J; Oksanen, Laura J; Tzameli, Iphigenia; Bj�rb�k, Christian; Flier, Jeffrey S // Nature Medicine;Jul2004, Vol. 10 Issue 7, p734
Leptin is an adipocyte-derived hormone that regulates energy balance and neuroendocrine function primarily by acting on specific hypothalamic pathways. Resistance to the weight reducing effects of leptin is a feature of most cases of human and rodent obesity, yet the molecular basis of leptin...
