TITLE

Novel Methods for Detection and Measurement of Organ Fibrosis in Kidney, Bone Marrow, and Urological Diseases (U01)

PUB. DATE
October 2013
SOURCE
NIH Guide for Grants & Contracts;10/25/2013, p26
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
91995981

 

Related Articles

  • CCR2 Regulates the Uptake of Bone Marrow-Derived Fibroblasts in Renal Fibrosis. Xia, Yunfeng; Entman, Mark L.; Wang, Yanlin // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment of bone marrow-derived fibroblasts into the kidney are incompletely understood. Bone marrow-derived...

  • A SIGNIFICANT PROPORTION OF MYOFIBROBLASTS ARE OF BONE MARROW ORIGIN IN HUMAN LIVER FIBROSIS. Russo, F. P.; Burra, P.; Rugge, M.; Wright, N. A.; Alison, M. R.; Forbes, S. J. // Gut;Apr2004 Supplement 3, Vol. 53, pA12 

    Myofibroblasts of bone marrow origin have recently been found in a number of parenchymal organs such as the gut and kidney. Authors sought to analyse the origin of myofibroblasts within fibrotic liver in two scenarios: 8 male patients, who received liver transplants from female donors and...

  • Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. Yang, Juan; Zhu, Fengming; Wang, Xiaohui; Yao, Weiqi; Wang, Meng; Pei, Guangchang; Hu, Zhizhi; Guo, Yujiao; Zhao, Zhi; Wang, Pengge; Mou, Jingyi; Sun, Jie; Zeng, Rui; Xu, Gang; Liao, Wenhui; Yao, Ying // PLoS ONE;2/22/2016, Vol. 11 Issue 2, p1 

    AMD3100 is a small molecule inhibitor of chemokine receptor type 4 (CXCR4), which is located in the cell membranes of CD34+ cells and a variety of inflammatory cells and has been reported to reduce organ fibrosis in the lung, liver and myocardium. However, the effect of AMD3100 on renal fibrosis...

  • Bone marrow dosimetry in peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate. Forrer, Flavio; Krenning, Eric P.; Kooij, Peter P.; Bernard, Bert F.; Konijnenberg, Mark; Bakker, Willem H.; Teunissen, Jaap J. M.; de Jong, Marion; van Lom, Kirsten; de Herder, Wouter W.; Kwekkeboom, Dik J. // European Journal of Nuclear Medicine & Molecular Imaging;Jul2009, Vol. 36 Issue 7, p1138 

    Adequate dosimetry is mandatory for effective and safe peptide receptor radionuclide therapy (PRRT). Besides the kidneys, the bone marrow is a potentially dose-limiting organ. The radiation dose to the bone marrow is usually calculated according to the MIRD scheme, where the accumulated activity...

  • Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling. Mutlu, Gökhan M.; Budinger, G. R. Scott; Minghua Wu; Lam, Anna P.; Zirk, Aaron; Rivera, Stephanie; Urich, Daniela; Chiarella, Sergio E.; Go, Leonard H. T.; Ghosh, Asish K.; Selman, Moises; Pardo, Annie; Varga, John; Kamp, David W.; Chandel, Navdeep S.; Sznajder, Jacob Iasha; Jain, Manu // Thorax;Feb2012, Vol. 67 Issue 2, p139 

    Background The development of organ fibrosis after injury requires activation of transforming growth factor β1 which regulates the transcription of profibrotic genes. The systemic administration of a proteasomal inhibitor has been reported to prevent the development of fibrosis in the liver,...

  • Diagnostic Assessment of Bone Marrow Aspiration Smears, Touch Imprints and Trephine Biopsy in Non- Haematological Disorders. Gupta, Nitin; Kumar, Ram; Khajuria, Arvind // JK Science;Apr-Jun2011, Vol. 13 Issue 2, p70 

    Diagnostic Assessment of bone marrow aspirate particle smears, imprints and biopsy sections was done on 10 Non- Haematological disorders. Core needle biopsy of the bone marrow is a safe and useful procedure. It is a valuable diagnostic aid for measurement of marrow cellularity, metastatic...

  • Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model. Reich, Barbara; Schmidbauer, Kathrin; Rodriguez Gomez, Manuel; Johannes Hermann, Fabian; Göbel, Nicole; Brühl, Hilke; Ketelsen, Isabel; Talke, Yvonne; Mack, Matthias // Kidney International;Jul2013, Vol. 84 Issue 1, p78 

    Collagen-producing bone marrow-derived cells (fibrocytes) have been detected in animal models and patients with fibrotic diseases. In vitro data suggest that they develop from monocytes with the help of accessory cells and profibrotic soluble factors. Using a mouse model of renal fibrosis,...

  • NEWS & Reviews.  // Contemporary Urology;Sep2006, Vol. 18 Issue 9, p7 

    The article offers updates in urology. According to a survey conducted by "Contemporary Urology/Urology Times," declining practice reimbursements is the number one reason behind the retirement of urologists. The U.S. Court of Appeals ruled in the case against the U.S. FDA by the Abigail Alliance...

  • A novel model of adenine-induced tubulointerstitial nephropathy in mice. Ting Jia; Hannes Olauson; Lindberg, Karolina; Amin, Risul; Edvardsson, Karin; Lindholm, Bengt; Andersson, Göran; Wernerson, Annika; Sabbagh, Yves; Schiavi, Susan; Larsson, Tobias E. // BMC Nephrology;2013, Vol. 14 Issue 1, p1 

    Background: In vivo models of uremia are important tools to study numerous aspects of acute and chronic kidney disease. Mouse models are pivotal because most genetically engineered animal models are mice, which allow dissecting the impact of selected target genes in renal failure. Adenine-based...

  • Diagnostic Assessment of Bone Marrow Aspiration Smears, Touch Imprints and Trephine Biopsy in Haematological Disorders. Gupta, Nitin; Kumar, Ram; Khajuria, Arvind // JK Science;Jul-Sep2010, Vol. 12 Issue 3, p130 

    Diagnostic Assessment of bone marrow aspirate particle smears, imprints and biopsy sections was done on 40 haematological disorders. Core needle biopsy of the bone marrow is a safe and useful procedure. It is a valuable diagnostic aid for measurement of marrow cellularity and fibrosis. Bilateral...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics