TITLE

microRNA-34a promotes DNA damage and mitotic catastrophe

AUTHOR(S)
Kofman, Alexander V.; Jungeun Kim; So Yeon Park; Dupart, Evan; Letson, Christopher; Yongde Bao; Kai Ding; Quan Chen; Schiff, David; Larner, James; Abounader, Roger
PUB. DATE
November 2013
SOURCE
Cell Cycle;11/15/2013, Vol. 12 Issue 22, p3500
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
91986798

 

Related Articles

  • Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Nitta, Masayuki; Kobayashi, Osamu; Honda, Shinobu; Hirota, Toru; Kuninaka, Shinji; Marumoto, Tomotoshi; Ushio, Yukitaka; Saya, Hideyuki // Oncogene;8/26/2004, Vol. 23 Issue 39, p6548 

    Mitotic catastrophe is an important mechanism for the induction of cell death in cancer cells by antineoplastic agents that damage DNA. This process is facilitated by defects in the G1 and G2 checkpoints of the cell cycle that are apparent in most cancer cells and which allow the cells to enter...

  • Mitotic Catastrophe as a Consequence of Chemotherapy. Mansilla, Sylvia; Bataller, Marc; Portugal, José // Anti-Cancer Agents in Medicinal Chemistry;2006, Vol. 6 Issue 6, p589 

    According to a widespread model, anti-cancer chemotherapy involves the triggering of tumor cells to undergo apoptosis, so apoptosis-resistant cells would be recalcitrant to such therapy. However, in addition to apoptosis, which is mainly dependent on the activity of the tumor suppressor protein...

  • A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Sharma, S S; Ma, L; Bagui, T K; Forinash, K D; Pledger, W J // Oncogene;8/30/2012, Vol. 31 Issue 35, p3989 

    Mitotic catastrophe occurs when cells enter mitosis with damaged DNA or excess centrosomes. Cells overexpressing the centrosome protein CP110 or depleted of cyclin F, which targets CP110 for destruction, have more than two centrosomes and undergo mitotic catastrophe. Our studies show centrosome...

  • Mechanisms of Drug-Induced Mitotic Catastrophe in Cancer Cells. Portugal, José; Mansilla, Sylvia; Bataller, Marc // Current Pharmaceutical Design;1/1/2010, Vol. 16 Issue 1, p69 

    Mitotic catastrophe is a mechanism of cell death characterized by the occurrence of aberrant mitosis with the formation of large cells that contain multiple nuclei, which are morphologically distinguishable from apoptotic cells. Sometimes, mitotic catastrophe is used restrictively to indicate a...

  • 14-3-3sigma is required to prevent mitotic catastrophe after DNA damage. Chan, Timothy A; Hermeking, Heiko; Lengauer, Christoph; Kinzler, Kenneth W; Vogelstein, Bert // Nature;10/7/1999, Vol. 401 Issue 6753, p616 

    Presents research on the role of 14-3-3sigma to prevent mitotic catastrophe after DNA damage. Description of an approach to the generation of human somatic-cell knockouts, which are used to generate human colorectal cancer cells in which both 14-3-3sigma alleles are inactivated; Implications...

  • Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Al-Ejeh, F; Kumar, R; Wiegmans, A; Lakhani, S R; Brown, M P; Khanna, K K // Oncogene;11/18/2010, Vol. 29 Issue 46, p6085 

    The DNA-damage response (DDR) pathways consist of interconnected components that respond to DNA damage to allow repair and promote cell survival. The DNA repair pathways and downstream cellular responses have diverged in cancer cells compared with normal cells because of genetic alterations that...

  • Mitotic catastrophe is the predominant response to histone acetyltransferase depletion. Ha, G.-H.; Kim, H.-S.; Lee, C. G.; Park, H.-Y.; Kim, E.-J.; Shin, H.-J.; Lee, J.-C.; Lee, K.-W.; Lee, C.-W. // Cell Death & Differentiation;Mar2009, Vol. 16 Issue 3, p483 

    Histone acetylation induces chromatin opening by perturbing higher-order chromatin compaction and folding, suggesting that histone acetylation and deacetylation dynamics are central to chromosome condensation or decondensation. The condensation of chromosomes during mitosis is an essential...

  • Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Castedo, Maria; Perfettini, Jean-Luc; Roumier, Thomas; Valent, Alexander; Raslova, Hana; Yakushijin, Kenichi; Horne, David; Feunteun, Jean; Lenoir, Gilbert; Medema, René; Vainchenker, William; Kroemer, Guido // Oncogene;5/27/2004, Vol. 23 Issue 25, p4362 

    A conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe when the DNA structure checkpoints are inactivated, for instance when the checkpoint kinase Chk2 is inhibited. Here we show that in such conditions, cells die during the metaphase of the cell cycle, as a result of...

  • E2F1-mediated DNA damage is implicated in 8-Cl-adenosine-induced chromosome missegregation and apoptosis in human lung cancer H1299 cells. Han, Yu-Ying; Zhou, Zhe; Cao, Ji-Xiang; Jin, Ya-Qiong; Li, Shu-Yan; Ni, Ju-Hua; An, Guo-Shun; Zhang, Yu-Xiang; Jia, Hong-Ti // Molecular & Cellular Biochemistry;Dec2013, Vol. 384 Issue 1/2, p187 

    Although E2F1-mediated DNA double-stranded breaks (DSBs) and tetraploid have been extensively studied, the role of E2F1 in mitotic catastrophe is still unknown. We have previously shown that 8-chloro-adenosine (8-Cl-Ado) induces DNA DSBs and aberrant mitosis in human lung cancer cells, followed...

  • Various modes of cell death induced by DNA damage. Surova, O; Zhivotovsky, B // Oncogene;8/15/2013, Vol. 32 Issue 33, p3789 

    The consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury leads to the appearance of cells that carry mutations or causes a shift towards induction of the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics