TITLE

ENOXAPARIN FOR THROMBOSIS IN NEONATES: PRELIMINARY REPORT

AUTHOR(S)
PIERSIGILLI, Fiammetta; AURITI, Cinzia; HAYWOOD LOMBARDI, Mary; PRENCIPE, Giusi; CAMPI, Francesca; DOTTA, Andrea
PUB. DATE
October 2013
SOURCE
Pedijatrija Danas: Pediatrics Today;Oct2013, Vol. 9 Issue 2, p170
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives -- To investigate the dose of enoxaparin required in neo-nates to achieve target therapeutic ranges of anti factor Xa 48 hours after starting therapy, and compare this dose to recommended guideline dosages for neonates. Methods -- We retrospectively reviewed 19 records of newborns who received enoxaparin at different doses for the treatment of thrombosis and evaluated how many among them reached the target anti-factor Xa level after 48 hours. Results -- Only 1/5 neonates (20%) treated with 150 UI/kg twice a day, but 100% (6/6) of those treated with 175 UI/kg twice a day reached therapeutic levels of anti-factor Xa at 48 hours. Of the 8 neonates treated with lower starting doses none reached the therapeutic range after 48 hours and these required the highest number of dose changes. Conclusions -- Our results reinforce the need to increase in neonates the dosage of enoxaparin suggested in published guidelines, in order to shorten the time-delay in achieving a therapeutic level of anti-factor Xa, and also reducing the number of blood tests necessary for dosing anti-factor Xa.
ACCESSION #
91985158

 

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