TITLE

Antispasmodic and Hypoglycemic Effects of Aqueous Extract of Ajuga iva L. in Induced Diabetic Rats

AUTHOR(S)
ROUIBI, Abdelhak; KHALI, Mustapha; SAIDI, Fairouz
PUB. DATE
July 2013
SOURCE
Bulletin of the University of Agricultural Sciences & Veterinary;2013, Vol. 70 Issue 2, p339
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A pharmacological study of aqueous extract of the aerial parts of Ajuga iva L. was performed using animal models. The administration of different doses (0.025 g/mL; 0.05 g/ mL; 0.13 g/mL; 0.2 g/ml and 0.4 g/mL) of the aqueous extract caused a decrease in the number of abdominal cramps in the same time interval. Doses of 0.13 g/mL, 0.2 g/mL, 0.4 g/mL generated an increase in the percentage of inhibition of contractions of 79.78±4.64, 85.39±4.29 to 96±5.20, respectively, compared to the control (77.53±3.80). These results indicate that doses 0.13 g/mL, 0.2 g/mL and 0.4 g/mL of aqueous extract of Ajuga iva L. are more effective than the analgesic effect of ibuprofen. The single and repeated administration of aqueous extract (0.15 g/L) orally for 3 weeks reduced the blood glucose levels significantly (70%) in diabetic rats compared with the percentage reduction levels in rats of control group treated with Diabenil ® (47.81%). The administration of 0.15 g/L aqueous extract of the plant decreased blood glucose levels.
ACCESSION #
91981508

 

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