TITLE

THE MEAN PLATELET VOLUME IS INCREASED IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES MELLITUS, BUT NOT IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE

AUTHOR(S)
Babić, Nermina; Avdagić, Nesina; Musić, Miralem; Huskić, Jasminko; Dervišević, Amela; Velija-Ašimi, Zelija; Mujanović-Narančić, Alma; Nakaš-Ićindić, Emina
PUB. DATE
July 2013
SOURCE
Medical Journal;jul-sep2013, Vol. 19 Issue 3, p224
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Increased mean platelet volume (MPV) could contribute to increased risk of developing cardiovascular complications. The aim of the study was to evaluate the relationship of the MPV with glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) in type 1 and 2 diabetic patients (DM1 and DM2), patients with impaired glucose tolerance (IGT) and to examine whether MPV would be useful for differentiating diabetic and IGT patients from healthy subjects. Study included 32 DM1, 36 DM2, 30 IGT patients and 30 healthy subjects. The MPV values in both DM1 and DM2 group were significantly higher than in IGT patients (p=0,02; p=0,002) and control group (p=0,002; p=0,001). There were no statistically significant differences in MPV between two diabetic groups. There was a significant positive correlation between MPV and FBG (r=0,426; p=0,043) in DM2 group. There was no significant correlation between MPV and HbA1c levels in any groups. The overall accuracy of MPV in differentiating DM1 patients from control was 68,6% (cutoff: 8,54 fL) and DM2 patients from control 75,5% (cutoff 8,73 fL). No significant correlation was identified between MPV and poor glycemic control, elevated HbA1c, in diabetic patients. MPV could be used as an additional biomarker in distinguishing diabetic patients, but not IGT patients from healthy subjects.
ACCESSION #
91977167

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics