TITLE

Polyclonal Antibody Targeting SOX11 Cannot Differentiate Mantle Cell Lymphoma From B-Cell Non-Hodgkin Lymphomas

AUTHOR(S)
Li-Na Zhang; Ting-Xun Lu; Xin Cao; Lei Fan; PhD; Li Wang; Ji Xu; Run Zhang; Zhi-Jian Zou; Jia-Zhu Wu; Jian-Yong Li; Wei Xu
PUB. DATE
December 2013
SOURCE
American Journal of Clinical Pathology;Dec2013, Vol. 140 Issue 6, p795
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To determine whether SOX11 is a diagnostic marker of mantle cell lymphoma (MCL). Methods: We analyzed SOX11 expression in 349 B-cell non-Hodgkin lymphomas (B-NHLs) via immunohistochemistry. Results: Nuclear staining of SOX11 was observed in 54 (93.1%) of 58 MCLs. We noticed that SOX11 protein was also expressed on the nuclei in 8 (21.6%) of 37 B-lymphoblastic lymphomas, 45 (32.6%) of 138 diffuse large B-cell lymphomas, 15 (44.1%) of 34 follicular lymphomas, 8 (30.8%) of 26 Burkitt lymphomas, 2 (10.0%) of 20 chronic lymphocytic leukemia/small cell lymphomas, and 3 (18.8%) of 16 marginal zone lymphomas. Conclusions: Although the positive rate of SOX11 expression in MCL was significantly higher than other B-NHLs (P < .001), polyclonal antibody targeting SOX11 is not able to identify MCL from B-NHLs because the nuclear staining of SOX11 was widely positive in B-NHLs.
ACCESSION #
91961361

 

Related Articles

  • Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells. Lee, Min Joung; Kim, Namju; Choe, Ji-Young; Khwarg, Sang In; Jeon, Yoon Kyung; Choung, Ho-Kyung; Kim, Ji Eun // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of...

  • A Pelvic Mass in a 20-Year-Old Man. Sun-Young Jun; Jooryung Huh, Sung-Hye; Park, Jae Y.; Ro // Archives of Pathology & Laboratory Medicine;Oct2003, Vol. 127 Issue 10, pe411 

    Presents the case of a 20-year-old Korean man diagnosed with diffuse large B-cell lymphoma with Homer-Wright-type Rosette formation. Medical history of the patient; Results of examination by light microscopy; Immunohistochemistry technique for tumor diagnosis; Considerations in the diagnosis of...

  • Primary diffuse large B-cell lymphoma of the ovary is of a germinal centre B-cell-like phenotype. Sun, Jian; Zhang, Jing; Ling, Qing; Luo, Yufeng; Wu, Shafei; Liang, Zhiyong; Zhong, Dingrong; Zeng, Xuan // Virchows Archiv;Jan2015, Vol. 466 Issue 1, p93 

    Primary ovarian lymphoma is rare. To better understand the clinicopathological and molecular features of these tumours, we studied 14 patients (age range 13 to 74 years, mean 46.9 years) with non-Hodgkin's lymphoma who initially presented with an ovarian tumour. The clinicopathological features...

  • Immunohistochemical Detection of MYC-driven Diffuse Large B-Cell Lymphomas. Kluk, Michael J.; Chapuy, Bjoern; Sinha, Papiya; Roy, Alyssa; Cin, Paola Dal; Neuberg, Donna S.; Monti, Stefano; Pinkus, Geraldine S.; Shipp, Margaret A.; Rodig, Scott J. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Diffuse large B cell lymphoma (DLBCL) is a clinically and genetically heterogeneous disease. A small subset of DLBCLs has translocations involving the MYC locus and an additional group has amolecular signature resembling Burkitt lymphoma (mBL). Presently, identification of such cases by...

  • Transformation of Follicular Lymphoma to Precursor B-Cell Lymphoblastic Lymphoma With c-myc Gene Rearrangement as a Critical Event. Ken Young; Qingmei Xie; Guimei Zhou; Jens Eickhoff; Warren Sanger; Patricia Aoun; Wing Chan // American Journal of Clinical Pathology;Jan2008, Vol. 129 Issue 1, p157 

    Progression of follicular lymphoma (FL) to a higher-grade lymphoma occurs in 25% to 60% of cases and frequently indicates a poor prognosis. The transformation is accompanied by alteration in morphologic features and clinical behaviors. Herein, we report a case of FL occurring in a 59-year-old...

  • Diffuse Large B-Cell Lymphoma Initially Manifesting in the Bone Marrow. Dai Kajiura; Yoriko Yamashita; Naoyoshi Mori // American Journal of Clinical Pathology;May2007, Vol. 127 Issue 5, p762 

    We histologically and immunohistochemically studied 37 cases of diffuse large B-cell lymphoma (DLBCL) initially manifesting in the bone marrow (BM). We also compared these cases with the Asian variant of intravascular large B-cell lymphoma (AIVL). Histologically, the neoplastic cells of the BM...

  • Generation and selection of immunized Fab phage display library against human B cell lymphoma. Yongmei Shen; Xiaochun Yang; Ningzheng Dong; Xiaofang Xie; Xia Bai; Yizhen Shi // Cell Research;Jul2007, Vol. 17 Issue 7, p650 

    The approval of using monoclonal antibodies as a targeted therapy in the management of patients with B cell lymphoma has led to new treatment options for this group of patients. Production of monoclonal antibodies by the traditional hybridoma technology is costly, and the resulting murine...

  • DIAGNOSTIC DIFFICULTIES IN RECOGNIZING B-CELL LYMPHOMAS IN MEDIASTINAL TUMORS - THREE CASE. Poniatowska-Broniek, Gra┼╝yna; Sikorska, Magdalena; Sulik, Marian; Nawrocki, Sergiusz; Maruszak, Klaudia; Gizelbach-┼╗ochowska, Karolina // Polish Annals of Medicine / Rocznik Medyczny;2010, Vol. 17 Issue 1, p71 

    Introduction. The most frequently diagnosed mediastinal lymphomas include: Nodular Sclerosis Classical Hodgkin Lymphoma (NSCHL) and Primary Mediastinal Large B-cell Lymphoma (PMBL). In the new, 4th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissue of 2008, a new...

  • New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphoma. H Adams // Journal of Clinical Pathology;Nov2009, Vol. 62 Issue 11, p986 

    AIMS: Receiver operating characteristic (ROC) curve analysis is a well-established method to study the accuracies of biological markers. It may, however, be suboptimal for analysing outcomes over time, such as prognosis. Here, the clinical value of time-dependent ROC curve analysis for improving...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics