Polyclonal Antibody Targeting SOX11 Cannot Differentiate Mantle Cell Lymphoma From B-Cell Non-Hodgkin Lymphomas

Li-Na Zhang; Ting-Xun Lu; Xin Cao; Lei Fan; PhD; Li Wang; Ji Xu; Run Zhang; Zhi-Jian Zou; Jia-Zhu Wu; Jian-Yong Li; Wei Xu
December 2013
American Journal of Clinical Pathology;Dec2013, Vol. 140 Issue 6, p795
Academic Journal
Objectives: To determine whether SOX11 is a diagnostic marker of mantle cell lymphoma (MCL). Methods: We analyzed SOX11 expression in 349 B-cell non-Hodgkin lymphomas (B-NHLs) via immunohistochemistry. Results: Nuclear staining of SOX11 was observed in 54 (93.1%) of 58 MCLs. We noticed that SOX11 protein was also expressed on the nuclei in 8 (21.6%) of 37 B-lymphoblastic lymphomas, 45 (32.6%) of 138 diffuse large B-cell lymphomas, 15 (44.1%) of 34 follicular lymphomas, 8 (30.8%) of 26 Burkitt lymphomas, 2 (10.0%) of 20 chronic lymphocytic leukemia/small cell lymphomas, and 3 (18.8%) of 16 marginal zone lymphomas. Conclusions: Although the positive rate of SOX11 expression in MCL was significantly higher than other B-NHLs (P < .001), polyclonal antibody targeting SOX11 is not able to identify MCL from B-NHLs because the nuclear staining of SOX11 was widely positive in B-NHLs.


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