TITLE

In vivo anti-inflammatory and antinociceptive activities of the aerial part extract of Dicliptera laxata

AUTHOR(S)
Wolde-Mariam, Messay; Yarlagadda, Raghavendra; Asres, Kaleab
PUB. DATE
July 2013
SOURCE
International Journal of Green Pharmacy (Medknow Publications & ;Jul-Sep2013, Vol. 7 Issue 3, p216
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Dicliptera laxata (Acanthaceae) is a perennial herb with stems creeping and rooting and its aerial parts are used for the treatment of headache, by using the nasal route of administration. A blood red decoction of the aerial part of D. laxata is taken for orofacial inflammation. Aims: In the present study, the in vivo anti-inflammatory and antinociceptive effects of the aqueous aerial part extract of D. laxata were investigated. Materials and Methods: The anti-inflammatory effect was evaluated using the carrageenan-induced mouse pedal (paw) edema model, while the formalin test in mice was employed to study the antinociceptive activity. Results: Administration of 400 mg/kg p.o. of the aqueous extract of the aerial parts of D. laxata produced significant (P < 0.05 - 0.01) anti-inflammatory effects against carrageenan-induced acute inflammation and formalin-induced nociceptive pain stimulus in mice. Bioassay-guided fractionation of the total extract indicated that the water fraction was by far the most potent in both models. Conclusions: The present findings indicate that D. laxata possesses genuine anti-inflammatory and antinociceptive properties, lending pharmacological support to the folkloric or anecdotal use of the plant in the treatment and/or management of painful inflammatory conditions. To the best of our knowledge, this is the first report on the anti-inflammatory and antinociceptive activities of the extracts and isolated compound (DL-1) of D. laxata.
ACCESSION #
91960019

 

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