TITLE

Anti-allergic and anti-anaphylactic activities of Dolichos biflorus

AUTHOR(S)
Ashok Suralkar, Anupama; Kasture, Sanjay B.
PUB. DATE
July 2013
SOURCE
International Journal of Green Pharmacy (Medknow Publications & ;Jul-Sep2013, Vol. 7 Issue 3, p196
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The seeds of Dolichos biflorus (DB) have been traditionally used in the treatment of cough and asthma. Aim: Based on the traditional claim, the present study was planned to evaluate the anti-allergic and anti-anaphylactic activities of DB. Materials and Methods: The ethanolic extract of the seeds of DB was prepared by cold maceration process. DB was subjected to phytochemical screening, acute toxicity studies, mast cell-stabilizing activity using compound 48/80 and anti-allergic activity using milk-induced leukocytosis and eosinophilia and passive paw anaphylaxis. Statistical Analysis: Statistical analysis was done by using one-way analysis of variance followed by Dunnett's test. Results: The phytochemical investigation showed presence of proteins, flavonoids and glycosides. DB extract inhibited milk-induced leukocytosis and eosinophilia and also the compound 48/80 induced mast cell degranulation. DB extract significantly reduced passive paw anaphylaxis in a dose-dependent manner. Conclusion: The results demonstrated that DB extract possesses anti-allergic and anti-anaphylactic potentials that might be useful in the management of asthma.
ACCESSION #
91960015

 

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