Thyroid Stimulating Hormone Assay as the First Line Biochemical Parameter to Determine Thyroid Gland Abnormalities

Eniola Olooto, Wasiu; Olufemi Adeleye, Adebambo; Adetola Amballi, Adebayo; Oladipupo Mosuro, Ademola; Abayomi Banjo, Taiwo
January 2014
Pakistan Journal of Biological Sciences;2014, Vol. 17 Issue 1, p118
Academic Journal
Increased cellular catabolic activities observed in hyperthyroid state had been established. This is consequent to excessive hormones secreted by the thyroid gland during this condition. A total of 60 subjects comprising of 45 females mean age 43.02±1.90 (range 22-70 years) and 15 males mean age 50.40±3.59 (range 25-68) and 60 controls comprising of 45 females mean age 41.18±1.68 (range 22-68 years) and 15 males mean age 40.53±2.88 (range 25-65) were recruited for the study. The plasma level of T4, T3 and TSH were determined in both the experiment group and the controls. A significant increase (p<0.05) in plasma T4, T3 and a significant decrease (p<0.05) in plasma TSH were observed in the experiment group in comparison to the controls. Also, an inverse relationship was noted to exist between the plasma T4 and T3; and TSH in primary hyperthyroid state.


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