TITLE

Neurological and cytological response as potential early predictors of time-to-progression and overall survival in patients with leptomeningeal carcinomatosis treated with intrathecal liposomal cytarabine: a retrospective cohort study

AUTHOR(S)
Fusco, Juan P.; Castañón, Eduardo; Carranza, Omar E.; Zubiri, Leire; Martín, Patricia; Espinós, Jaime; Rodríguez, Javier; Santisteban, Marta; Aramendía, José M.; Gil-Bazo, Ignacio
PUB. DATE
December 2013
SOURCE
Journal of Neuro-Oncology;Dec2013, Vol. 115 Issue 3, p429
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Interesting neurological and cytological response rates after intrathecal (i.t) liposomal cytarabine have been observed in patients with leptomeningeal carcinomatosis (LMC) from solid tumors. However, the potential use of those responses as early predictors of time-to-progression (TTP) and overall survival (OS) is unexplored. 27 consecutive patients with LMC treated with 50 mg i.t liposomal cytarabine under compassionate drug use were retrospectively studied. All patients received i.t treatment every 2 weeks during induction and every 4 weeks during maintenance periods. Neurological and cytological responses were assessed before every liposomal cytarabine cycle. Most of the patients were female (17/27) diagnosed with breast cancer (15/27). A complete neurological response was seen among 11 % of the patients; partial response in 22 % of the patients; stable disease in 30 % of the patients and progressive disease in 37 % of them. Cytological assessment was available in 11/27 patients showing a 26 % complete response rate. The median time to neurological and cytological response was 15 days and 14 days, respectively. Patients showing a combined neurological and cytological response showed a significantly longer median TTP (122 vs. 3 days; p = 0.001) and OS (141 vs. 3 days; p = 0.002) compared to those showing both neurological and cytological progression. No grade 4 toxicities were recorded. According to these preliminary results, early neurological and cytological responses may be further studied as early predictors of TTP and OS in patients receiving i.t liposomal cytarabine for LMC.
ACCESSION #
91933409

 

Related Articles

  • Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study. Scott, Brian; van Vugt, Vincent; Rush, Toni; Brown, Tiffany; Chen, Clark; Carter, Bob; Schwab, Richard; Fanta, Paul; Helsten, Teresa; Bazhenova, Lyudmila; Parker, Barbara; Pingle, Sandeep; Saria, Marlon; Brown, Bradley; Piccioni, David; Kesari, Santosh // Journal of Neuro-Oncology;Sep2014, Vol. 119 Issue 2, p361 

    Leptomeningeal metastasis (LM) from solid tumors is typically a late manifestation of systemic cancer with limited survival. Randomized trials comparing single agent intrathecal methotrexate to liposomal cytarabine have shown similar efficacy and tolerability. We hypothesized that combination...

  • Breast cancer and leptomeningeal disease (LMD): hormone receptor status influences time to development of LMD and survival from LMD diagnosis. Yust-Katz, S.; Garciarena, P.; Liu, D.; Yuan, Y.; Ibrahim, N.; Yerushalmi, R.; Penas-Prado, M.; Groves, M. // Journal of Neuro-Oncology;Sep2013, Vol. 114 Issue 2, p229 

    Leptomeningeal disease (LMD) occurs in 5 % of breast cancer patients. The aim of this study was to identify risk factors related to survival and time to development of LMD in breast cancer patients. A retrospective analysis of breast cancer patients with LMD, evaluated in MDACC between 1995 and...

  • Barasertib improved survival in AML.  // Hem/Onc Today;6/10/2013, Vol. 14 Issue 11, p9 

    The article focuses on the effectiveness of Barasertib in fighting acute myeloid leukemia, which was able to deliver improved survival and manageable toxicity compared to low-dose cytosine arabinoside when used in affected older patients.

  • A multicentre retrospective comparison of central nervous system prophylaxis strategies among patients with high-risk diffuse large B-cell lymphoma. Cheah, C Y; Herbert, K E; O'Rourke, K; Kennedy, G A; George, A; Fedele, P L; Gilbertson, M; Tan, S Y; Ritchie, D S; Opat, S S; Prince, H M; Dickinson, M; Burbury, K; Wolf, M; Januszewicz, E H; Tam, C S; Westerman, D A; Carney, D A; Harrison, S J; Seymour, J F // British Journal of Cancer;9/9/2014, Vol. 111 Issue 6, p1072 

    Background:Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL) is a devastating complication; the optimal prophylactic strategy remains unclear.Methods:We performed a multicentre, retrospective analysis of patients with DLBCL with high risk for CNS relapse as defined by...

  • Identifying sentinel node could reduce surgery in breast cancer. Bower, Hilary // BMJ: British Medical Journal (International Edition);07/05/97, Vol. 315 Issue 7099, p9 

    Reports on the use of a radiographic procedure to identify a sentinel node in the armpit that could correctly assess the spread of cancer into the axilla in patients with breast cancer. Details of the procedure; Accurate identification of negative axilla; Prevention of unnecessary axillary...

  • Comparison of consolidation strategies in acute myeloid leukemia: high-dose cytarabine alone versus intermediate-dose cytarabine combined with anthracyclines. Kim, Dae; Kang, Ka-Won; Lee, Se; Park, Yong; Sung, Hwa; Kim, Seok; Choi, Chul; Kim, Byung // Annals of Hematology;Sep2015, Vol. 94 Issue 9, p1485 

    We compared the efficacy of high-dose cytarabine alone to that of intermediate-dose cytarabine combined with anthracyclines as consolidation therapy. Patients enrolled in the Korea University acute myeloid leukemia (AML) registry received remission induction chemotherapy with the same standard...

  • Role of immunohistochemical and histochemical profiling in H&E-based diagnosis of scrotal leiomyosarcoma of dartos muscle. Wincewicz, Andrzej; Lewitowicz, Piotr; Sulkowska, Urszula; Sulkowski, Stanislaw; Horecka-Lewitowicz, Agata; Koziel, Dorota; Gluszek, Stanislaw // Folia Histochemica et Cytobiologica;2013, Vol. 51 Issue 4, p339 

    Histochemical and immunohistochemical methods should often but not always complement standardized histopathologic procedures. Here, we illustrate use of these ancillary techniques in a report of scrotal leiomyosarcoma. 62-year-old male patient presented with a palpable, subcutaneous 2,5 cm wide...

  • Periodontal status and provision of periodontal services in Malaysia: are we meeting population needs? Mohd-Dom, Tuti N.; Aljunid, Syed M.; Manaf, Rizal A.; Muttalib, Khairiyah A.; Asari, Ahmad S. M. // BMC Health Services Research;2012, Vol. 12 Issue Suppl 1, p1 

    The article presents a study analyses periodontal status and population treatment needs of Malaysians and the trends of periodontal services offered by public dental clinics. The study adopts a retrospective study for secondary data analysis using three decennial national oral health surveys for...

  • Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80 years or older: a multi-center retrospective study. Nanjo, Yoshiro; Nagashima, Hideki; Dokai, Toshiyuki; Hamamoto, Yuki; Hashiguchi, Hirokazu; Ishii, Hiroyuki; Kameyama, Yasuhiro; Morio, Yasuo; Murata, Masaaki; Tanida, Atsushi; Tanishima, Shinji; Teshima, Ryota // Archives of Orthopaedic & Trauma Surgery;Sep2013, Vol. 133 Issue 9, p1243 

    Introduction: With increased aging of the population, spine surgeons have more opportunity to treat elderly patients for lumbar spinal stenosis (LSS). The purpose of this study was to clarify the clinical features and surgical outcomes for LSS in the elderly aged 80 years or older. Materials and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics