Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis

Ghia, Amol J.; Mahajan, Anita; Allen, Pamela K.; Armstrong, Terri S.; Lang Jr., Frederick F.; Gilbert, Mark R.; Brown, Paul D.
December 2013
Journal of Neuro-Oncology;Dec2013, Vol. 115 Issue 3, p513
Academic Journal
Observation following gross-total resection (GTR) for non-anaplastic supratentorial ependymomas is often advocated based on small, retrospective series. The purpose of this study is to perform a population-based analysis to examine outcomes for this rare cohort of low-risk patients. A retrospective analysis was conducted utilizing the Surveillance, Epidemiology and End Results Program of the United States National Cancer Institute. We identified patients with supratentorial non-anaplastic ependymoma who underwent GTR alone or GTR followed by radiation. We identified 92 patients who met these criteria. The median age was 17.5 years (range 1–83) with the majority female (58 %) and white (75 %). Radiotherapy (RT) was delivered in half of patients. The 5-/10-year Kaplan–Meier estimated overall survival (OS) and cause-specific survival (CSS) for the overall cohort was 83.2/71.4 and 84.1/78.0 %, respectively. There was no evidence of decreased CSS (HR 0.52 [0.18–1.51]; p = 0.23) or OS (HR 0.63 [0.25–1.59]; p = 0.33) with the omission of RT on univariate analysis. Age ≥18 years correlated with worse OS (HR 4.01 [1.45–11.11]; p = 0.008) and CSS (HR 2.86 [0.99–8.31]; p = 0.05). RT did not impact outcome for this low-risk cohort of patients. Older age correlates with poor prognosis.


Related Articles

  • Cranial and spinal oligodendrogliomatosis: a case report and review of the literature. Lee, Siang; Wong, Albert; Stadler, James; McClendon, Jamal; Smith, Timothy; Wadhwani, Nitin; Tomita, Tadanori // Child's Nervous System;Jan2015, Vol. 31 Issue 1, p147 

    Introduction: Oligodendrogliomatosis is a rarely reported entity in literature associated with poor prognosis in terms of length and quality of life. In this paper, we describe oligodendrogliomatosis in a 15-year-old male who initially presented with altered mental status due to diabetic...

  • Valor de la tomografía axial computarizada para el diagnóstico de tumores craneales supratentoriales. Martínez, Yaquelines Martín; Amelo, Inés María García; Viel, Valia Hernández; Mustelier, Nayrobis Miranda; Piorno, Raúl Domínguez // MEDISAN;2013, Vol. 17 Issue 2, p237 

    A descriptive and cross-sectional study was conducted in 94 patients with supratentorial brain tumors, hospitalized in the Department of Neurosurgery of "Saturnino Lora Torres" Provincial Teaching Clinical Surgical Hospital in Santiago de Cuba, from January 2009 to February 2011, in order to...

  • Supratentorial Mass Lesion Biopsy Using Frameless Stereotactic System; Diagnostic Yield, Surgical Morbidity, and Comparison With Freehand Biopsy. ABID, Muhammad; HUSSAIN, Kamran; SARWAR, Muhammad Afaq; SHAHID, Saman; AHMED, Nauman; SHEIKH, Shaharyar // Journal of Neurological Sciences;2015, Vol. 32 Issue 3, p461 

    Objective: The objective of this study is based on a comparison of freehand and stereotactic biopsy regarding diagnostic yield in terms of adequate tissue sample, morbidity in terms of postoperative complications like neurological deficit, bleeding, infection etc. and mortality. Material and...

  • Adult primitive neuroectodermal tumors: the prognostic value of supratentorial location. Gandhi, Rikesh; Babu, Ranjith; Cummings, Thomas; Adamson, Cory // Journal of Neuro-Oncology;Aug2013, Vol. 114 Issue 1, p141 

    Primitive neuroectodermal tumors (PNETs) are tumors which primarily consist of undifferentiated round neuroepithelial cells. Central nervous system PNETs can be divided into two genetically distinct groups: infratentorial PNET (iPNET)/medulloblastoma and supratentorial PNET (sPNET). Currently,...

  • Clinical and economic analysis of hospital acquired infections in patients diagnosed with brain tumor in a tertiary hospital. Undabeitia, J.; Liu, B.G.; Catalán, G.; Bilbao, G.; Pomposo, I.; Garibi, J.M. // Revista Neurocirugia;dic2011, Vol. 22 Issue 6, p535 

    Objectives. To analyze the relationship between hospital acquired infections and clinical outcomes, duration of stay, and cost per infectious episode in patients diagnosed with brain tumors in our service. Materials and methods. We conducted a retrospective study on patients diagnosed with brain...

  • Together and apart: providing psychosocial support for patients and families living with brain tumors. Kanter, Cheryl; D’Agostino, Norma Mammone; Daniels, Maureen; Stone, Alyson; Edelstein, Kim // Supportive Care in Cancer;Jan2014, Vol. 22 Issue 1, p43 

    Purpose: Brain tumors are associated with neurological sequelae and poor survival, contributing to distress in patients and their families. Our institution has conducted separate support groups for brain tumor patients and caregivers since 1999. This retrospective cohort study aimed to identify...

  • Intracranial pial fistulas in pediatric population. Clinical features and treatment modalities. Requejo, Flavio; Jaimovich, Roberto; Marelli, Juan; Zuccaro, Graciela // Child's Nervous System;Sep2015, Vol. 31 Issue 9, p1509 

    Purpose: The purpose of the study is to describe the clinical manifestations and treatment modalities of patients having intracranial pial arteriovenous fistulas (PAVFs). Methods: We retrospectively analyzed the cases of PAVFs from January 2004 to December 2013. Medical charts, diagnostic...

  • Remote site intracranial hemorrhage: Our experience and review of literature. Garg, Kanwaljeet; Tandon, Vivek; Sinha, Sumit; Suri, Ashish; Mahapatra, Ashok Kumar; Sharma, Bhawani Shankar // Neurology India;May/Jun2014, Vol. 62 Issue 3, p329 

    The article presents a summary of cases of patients with remote site intracranial hemorrhage who underwent cranial neurosurgical procedure. The results of an analysis of the indications for surgery in the supratentorial and infratentorial lesions, type of surgery done, site of remote bleed, the...

  • Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study. Aizer, Ayal A.; Ancukiewicz, Marek; Nguyen, Paul L.; MacDonald, Shannon M.; Yock, Torunn I.; Tarbell, Nancy J.; Shih, Helen A.; Loeffler, Jay S.; Oh, Kevin S. // Journal of Neuro-Oncology;Dec2013, Vol. 115 Issue 3, p411 

    Patients with World Health Organization (WHO) grade II supratentorial ependymomas are commonly observed after gross total resection (GTR), although supporting data are limited. We sought to characterize the natural history of such tumors. We used the Surveillance, Epidemiology, and End...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics