TITLE

Initial Intestinal Colonization in the Human Infant and Immune Homeostasis

AUTHOR(S)
Walker, W. Allan
PUB. DATE
November 2013
SOURCE
Annals of Nutrition & Metabolism;Nov2013 Supplement, Vol. 63, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The paradigm of disease burden in the developed world has changed drastically in the last few decades from predominately infections to immune-mediated diseases (autoimmunity and allergy) because of alterations in the Western lifestyle (improved sanitation, immunizations, antibiotic usage and altered dietary intake). A diverse balanced microbiota is necessary for the development of an appropriate innate and adaptive immune response. There is strong evidence that disruption of the normal colonization process can lead to alterations in the important symbiotic relationship that is necessary for immune homeostasis. For example, infants born by cesarean section or receiving excessive perinatal antibiotics have inadequate initial colonization and aberrant mucosal immune function. As a result, later in childhood, they express an increased incidence in asthma and autoimmune diseases (e.g. celiac disease). An important component of initial colonization is the infant's diet. Breast milk contains a variety of nondigestible oligosaccharides which function as prebiotics preferentially stimulating proliferation of Bifidobacteria and Lactobacilli, important health-promoting bacteria, and cause fermentation of the oligosaccharides into short-chain fatty acids. In the absence of breastfeeding for the first 6 months of life, formula containing pre- and probiotics may overcome an initial inadequate colonization process and help establish a normal mucosal immune system. © 2013 S. Karger AG, Basel
ACCESSION #
91932989

 

Related Articles

  • Functional Classification of the Gut Microbiota: The Key to Cracking the Microbiota Composition Code. Rosen, Connor E.; Palm, Noah W. // BioEssays;Dec2017, Vol. 39 Issue 12, pn/a 

    The last decade has seen an explosion of research on the gut microbiota-the trillions of microorganisms that colonize the human gut. It is now clear that interindividual diversity in microbiota composition plays an important role in determining susceptibility to a wide variety of diseases....

  • The ecological community of commensal, symbiotic, and pathogenic gastrointestinal microorganisms - an appraisal. Haque, Seraj Zohurul; Haque, Mainul // Clinical & Experimental Gastroenterology;May2017, Vol. 10, p91 

    The human gastrointestinal tract is inhabited by a vast population of bacteria, numbering ~100 trillion. These microorganisms have been shown to play a significant role in digestion, metabolism, and the immune system. The aim of this study was to review and discuss how the human body interacts...

  • The infant gut microbiome as a microbial organ influencing host well-being. Turroni, Francesca; Milani, Christian; Duranti, Sabrina; Lugli, Gabriele Andrea; Bernasconi, Sergio; Margolles, Abelardo; Di Pierro, Francesco; van Sinderen, Douwe; Ventura, Marco // Italian Journal of Pediatrics;2/5/2020, Vol. 46 Issue 1, p1 

    Initial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subsequent development of this early gut microbiota is driven and modulated by specific dietary...

  • Birth Mode-Related Differences in Gut Microbiota Colonization and Immune System Development. Francino, M. Pilar // Annals of Nutrition & Metabolism;2018 Supplement, Vol. 73, p12 

    Background: The process of early gut colonization is extremely variable among individuals and is influenced by numerous factors. Among these, the mode of birth will strongly shape the early microbial exposure and immune environment of the neonate. Summary: Here, I...

  • Editorial. Lifschitz, Carlos // Annals of Nutrition & Metabolism;Nov2013 Supplement, Vol. 63, p5 

    No abstract available

  • The microbiome revolution. Blaser, Martin J. // Journal of Clinical Investigation;Oct2014, Vol. 124 Issue 10, p4162 

    The collection of bacteria, viruses, and fungi that live in and on the human body, collectively known as the microbiome, has recently emerged as an important factor in human physiology and disease. The gut in particular is a biological niche that is home to a diverse array of microbes that...

  • Influences of microbiota on intestinal immune system development. Cebra, John J. // American Journal of Clinical Nutrition;May99, Vol. 69 Issue 5, p1046S 

    Focuses on the effects of gut microbes on the development of the mucosal immune system. Efficacy of certain intestinal microbes using neonatal conventionally reared mice and germ-free, deliberately colonized adult mice; Ability of commensal gut bacteria and enteric viruses to stimulate the...

  • Rational Design of Improved Pharmabiotics. Sleator, Roy D.; Hill, Colin // Journal of Biomedicine & Biotechnology;2009 Regular Issue, p1 

    Herein we review the most recent advances in probiotic research and applications with particular emphasis on the novel concept of patho-biotechnology: the application of pathogen-derived (ex vivo and in vivo) stress survival strategies for the design of more technologically robust and effective...

  • Reshaping the Gut Microbiota at an Early Age: Functional Impact on Obesity Risk? Luoto, R.; Collado, M.C.; Salminen, S.; Isolauri, E. // Annals of Nutrition & Metabolism;Nov2013 Supplement, Vol. 63, p17 

    Overweight and obesity can currently be considered a major threat to human health and well-being. Recent scientific advances point to an aberrant compositional development of the gut microbiota and low-grade inflammation as contributing factors, in conjunction with excessive energy intake. A...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics