TITLE

Application of a newly developed portable NIR imaging device to monitor the dissolution process of tablets

AUTHOR(S)
Ishikawa, Daitaro; Murayama, Kodai; Awa, Kimie; Genkawa, Takuma; Komiyama, Makoto; Kazarian, Sergei G.; Ozaki, Yukihiro
PUB. DATE
November 2013
SOURCE
Analytical & Bioanalytical Chemistry;Nov2013, Vol. 405 Issue 27, p9401
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have recently developed a novel portable NIR imaging device (D-NIRs), which has a high speed and high wavelength resolution. This NIR imaging approach has been developed by utilizing D-NIRs for studying the dissolution of a model tablet containing 20 % ascorbic acid (AsA) as an active pharmaceutical ingredient and 80 % hydroxypropyl methylcellulose, where the tablet is sealed by a special cell. Diffuse reflectance NIR spectra in the 1,000 to 1,600 nm region were measured during the dissolution of the tablet. A unique band at around 1,361 nm of AsA was identified by the second derivative spectra of tablet and used for AsA distribution NIR imaging. Two-dimensional change of AsA concentration of the tablet due to water penetration is clearly shown by using the band-based image at 1,361 nm in NIR spectra obtained with high speed. Moreover, it is significantly enhanced by using the intensity ratio of two bands at 1,361 and 1,354 nm corresponding to AsA and water absorption, respectively, showing the dissolution process. The imaging results suggest that the amount of AsA in the imaged area decreases with increasing water penetration. The proposed NIR imaging approach using the intensity of a specific band or the ratio of two bands combined with the developed portable NIR imaging instrument, is a potentially useful practical way to evaluate the tablet at every moment during dissolution and to monitor the concentration distribution of each drug component in the tablet. [Figure not available: see fulltext.]
ACCESSION #
91930463

 

Related Articles

  • New UV-Vis-NIR Spectrophotometer provides Highest Sensitivity Through Three Detectors.  // International Labmate;Oct0214, Vol. 39 Issue 7, p21 

    The article offers brief information on the UV-3600 Plus UV-Vis-NIR Spectrometer from Shimadzu.

  • New High Sensitivity Compact NIR Spectrometer.  // International Labmate;Apr2015, Vol. 40 Issue 3, p24 

    The article evaluates the near-infrared (NIR) 256-HSC (high sensitivity compact) spectrometer from Avantes.

  • Near-Infrared Spectroscopy. Morris, Rob // Labmate UK & Ireland;2011, Vol. 36 Issue 2, p4 

    The article previews the NIRQuest512-2.2 near-infrared (NIR) spectrometer from Ocean Optics.

  • High Resolution Near-Infrared Spectrometer with Spectral Response from 900-2500 nm.  // Labmate UK & Ireland;2011, Vol. 36 Issue 4, p18 

    The article previews the NIRQuest512-2.5 high resolution near-infrared spectrometer with spectral response by Ocean Optics.

  • Portable equipment aids farmers' decisions. Breazeale, Linda // Delta Farm Press;9/21/2012, Vol. 69 Issue 37, p9 

    The article discusses a near infrared reflectance (NIR) spectroscope, or portable forage tester, owned by Mississippi State University, which can be used to test hay crops such as ryegrass, small grains, and alfalfa.

  • Task-related brain activation during finger tapping and circle drawing monitored by fNIRS. Matsuzaki, Shuichi; Morihiro, Masamichi; Tsubone, Tadashi; Wada, Yasuhiro // BMC Neuroscience;2010 Supplement 1, Vol. 11, p1 

    The article presents a study on brain activation assessment measured by functional near-infrared spectroscopy (fNIRS) which performed two types of hand motor tasks such as finger tapping task and circle drawing task. The researchers employed 24-channel NIRS system for both experiments covering...

  • PRODUCT RESOURCES.  // Spectroscopy;Jul2013, Vol. 28 Issue 7, p46 

    The article evaluates several products related to spectroscopy including the UV-vis-NIR system, an ultraviolet visible near infrared spectrophotometer from bio-analytical instruments maker Agilent Technologies Inc., multichannel spectrometers from American analytical instruments maker Avantes...

  • Market Profile: Used IR and NIR Spectroscopy Instrumentation.  // Spectroscopy;Jun2013, Vol. 28 Issue 6, p11 

    The article offers information on the resale of old infrared (IR) and near-infrared (NIR)spectroscopy instrumentation discussing their share in the scientific instrumentation market, their reliability and performance and the upcoming report the Used Analytical Instrumentation Market, June 2013.

  • UVpolarizers.  // Spectroscopy;Jan2012, Vol. 27 Issue 1, p53 

    The article offers brief information on the 20/20 photovoltaic (PV) ultraviolet (UV)-vis-near infrared (NIR) microspectrophotometer from Craic Technologies Inc.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics