Correlation of contrast-enhanced ultrasound kinetics with prognostic factors in invasive breast cancer

Szabó, Botond K.; Saracco, Ariel; Tánczos, Ervin; Aspelin, Peter; Leifland, Karin; Wilczek, Brigitte; Axelsson, Rimma
December 2013
European Radiology;Dec2013, Vol. 23 Issue 12, p3228
Academic Journal
Objectives: To correlate contrast-enhanced ultrasound (CEUS) kinetic parameters with traditional and molecular prognostic factors in invasive breast cancer. Methods: Seventy-five invasive breast cancers were evaluated with contrast harmonic imaging after the injection of a bolus dose of 2.4 ml sulphur hexafluoride microbubble contrast agent. The lognormal function was used for quantitative analysis of kinetic data. These parameters correlated with traditional prognostic factors (tumour size, histological type, tumour grade, axillary lymph node status) and immunohistochemical biomarkers (ER, PR and HER2 status). Results: Statistically significant correlation was found between time-to-peak and tumour grade ( P value = 0.023), PR status ( P value = 0.042) and axillary node status ( P value = 0.025). Wash-out ratio, measured at 21 s was significantly associated with ER status ( P value = 0.042) and PR status ( P value = 0.026). Conclusions: Invasive breast carcinomas exhibiting earlier peak enhancement and faster elimination of microbubble contrast agent at CEUS are found to be associated with established predictors of poor prognosis. Key Points: • Contrast-enhanced ultrasound (CEUS) can potentially determine the aggressiveness of invasive breast cancers.• Early peak enhancement and accelerated wash-out at CEUS suggest poor prognosis.• CEUS kinetics are similar to that of DCE-MRI in assessing tumour aggressiveness.


Related Articles

  • Contrast-enhanced voiding urosonography phantom study: intravenous iodinated and gadolinium-based contrast agents may cause false-negative results in assessment of vesicoureteral reflux in children. Veldhoen, Simon; Sauer, Alexander; Gassenmaier, Tobias; Petritsch, Bernhard; Herz, Stefan; Blanke, Philipp; Derlin, Thorsten; Bley, Thorsten; Wirth, Clemens // Pediatric Radiology;Jun2015, Vol. 45 Issue 6, p862 

    Background: Contrast-enhanced voiding urosonography (ce-VUS) is commonly requested simultaneously to other diagnostic imaging necessitating intravenous contrast agents. To date there is limited knowldedge about intravesical interactions between different types of contrast agents. Objective: To...

  • The use of contrast-enhanced ultrasound with a second generation contrast medium: preliminary report in the dog. Volta, A.; Gnudi, G.; Manfredi, S.; Bertoni, G. // Veterinary Research Communications;Sep2009, Vol. 33 Issue 0, p221 

    This article presents a study which evaluated the use of a contrast specific harmonic ultrasound technique and a second generation contrast medium composed of sulphur hexafluoride encapsulated of a shell of phospholipids. The study considered nine lesions in dogs, including hepatic lesions, a...

  • Renal cell carcinoma: real-time contrast-enhanced ultrasound findings. Xu, Zuo-Feng; Xu, Hui-Xiong; Xie, Xiao-Yan; Liu, Guang-Jian; Zheng, Yan-Ling; Liang, Jin-Yu; Lu, Ming-De // Abdominal Imaging;Nov/Dec2010, Vol. 35 Issue 6, p750 

    Objective: To investigate the findings of renal cell carcinomas (RCCs) on contrast-enhanced ultrasound (CEUS). Methods: CEUS features of 84 RCCs confirmed by pathologic examination in 81 patients were retrospectively analyzed. A contrast-specific mode and a sulfur...

  • Tumor size of breast invasive ductal cancer measured with contrast-enhanced ultrasound predicts regional lymph node metastasis and N stage. Zhiyuan Wang; Qichang Zhou; Jun Liu; Shichu Tang; Xia Liang; Zhengyu Zhou; Ying He; Hui Peng; Yuanming Xiao // International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 10, p6985 

    Purpose: This study aimed to determine the role of breast invasive ductal cancer (BIDC) size measured with Contrast-enhanced Ultrasound (CEUS) in the prediction of regional lymph node metastasis (LNM) and N stage. Methods: One hundred and six consecutive patients with breast lesions underwent...

  • The place of CEUS in distinguishing benign from malignant cervical lymph nodes: a prospective study. Poanta, Laura; Serban, Oana; Pascu, Isabela; Pop, Sever; Cosgarea, Marcel; Fodor, Daniela // Medical Ultrasonography;Mar2014, Vol. 16 Issue 1, p7 

    Aims: The aim of the study was to evaluate the ability of contrast-enhanced ultrasonography (CEUS) compared to grayscale B-mode and color Doppler ultrasound in differentiate benign versus malign superficial cervical lymph nodes. Material and methods: In a prospective study ultrasonography (gray...

  • Epithelioid angiomyolipoma of the kidney: CT and CEUS characteristics and clinical outcomes. Dong-Wei Yao; Cheng Liu; Xue-Jun Liu; Duo Liu; Qing Zhang; Wei Wang; Guang-Xiang Liu; Xiao-Zhi Zhao; Hong-Qian Guo // International Journal of Clinical & Experimental Medicine;2016, Vol. 9 Issue 7, p14096 

    Objective: To review the computed tomography (CT) and contrast-enhanced ultrasonography (CEUS) features and clinical outcomes of renal epithelioid angiomyolipomas (EAMLs). Materials and methods: Seventeen patients diagnosed with EAML from January 2004 to June 2015 at the Second People's Hospital...

  • CITATIONS AND CLINICIANS' NOTES: BIOLOGY - PROGNOSTIC FACTORS.  // Current Medical Literature: Breast Cancer;2005, Vol. 17 Issue 2, p44 

    Discusses several studies focusing on the prognostic factors of breast cancer. Sentinel node biopsy in breast cancer; Prediction of the status of axillary sentinel lymph nodes in patients with invasive breast carcinoma; Sentinel node biopsy after previous breast surgery.

  • Mouse spontaneous mammary adenocarcinoma as a suitable model of breast cancer in Iran. Alizadeh, Ali Mohammad; Azizian, Saleh; Fayazi, Hamid Reza; Mousavi, Maryam-Sadat; Nabavi, Seyed Ali // Basic & Clinical Cancer Research;2011, Vol. 3 Issue 3/4, p30 

    Background: Breast cancer is a complicated disease and has various clinical manifestations and prognosis. The aim of this study is to make a breast cancer model suitable for basic, preclinical and clinical studies. Methods: Five virgin Bulb/c mice aged 6 weeks and spontaneous Murine Mammary...

  • Molecular alterations in metaplastic breast carcinoma. Cooper, Caroline Louise; Karim, Rooshdiya Z.; Selinger, Christina; Carmalt, Hugh; Soon Lee, C.; O'Toole, Sandra A. // Journal of Clinical Pathology;Jun2013, Vol. 66 Issue 6, p522 

    Metaplastic carcinoma of the breast is a rare and heterogeneous subtype of breast carcinoma with a generally poor outcome, and few therapeutic options once disease recurs or progresses. Metaplastic carcinomas of the breast are usually of a larger size at diagnosis, with less frequent nodal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics